Bleeding complications and mortality in warfarin-treated VTE patients, dependence of INR variability and iTTR

• Published in: Thrombosis and haemostasis Vol. 117; no. 1; p. 27
• Main Authors: Sandén, Per, Renlund, Henrik, Svensson, Peter J, Själander, Anders
• Format: Journal Article
• Language: English
• Published: Germany 01.01.2017
• Subjects: Aged; Aged, 80 and over; Anticoagulants - administration & dosage; Anticoagulants - adverse effects; Cause of Death; Drug Monitoring - methods; Female; Hemorrhage - chemically induced; Hemorrhage - mortality; Humans; International Normalized Ratio; Male; Middle Aged; Predictive Value of Tests; Proportional Hazards Models; Quality Indicators, Health Care; Registries; Risk Assessment; Risk Factors; Sweden - epidemiology; Time Factors; Treatment Outcome; Venous Thromboembolism - blood; Venous Thromboembolism - diagnosis; Venous Thromboembolism - drug therapy; Venous Thromboembolism - mortality; Warfarin - administration & dosage; Warfarin - adverse effects; INR variability; TTR; bleeding; venous thromboembolism; all-cause mortality; warfarin

High quality of warfarin treatment is important to prevent recurrence of venous thromboembolism (VTE) without bleeding complications. The aim of this study was to examine the effect of individual time in therapeutic range (iTTR) and International Normalised Ratio (INR) variability on bleeding risk a...