TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading

• Published in: Molecular psychiatry Vol. 26; no. 10; pp. 5925 - 5939
• Main Authors: Xu, Yin, Du, Shuqi, Marsh, Jacob A., Horie, Kanta, Sato, Chihiro, Ballabio, Andrea, Karch, Celeste M., Holtzman, David M., Zheng, Hui
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2021; Nature Publishing Group
• Subjects: 13/1; 13/106; 13/109; 13/51; 14/19; 38/77; 631/378; 64/110; 692/699; 82/80; Alzheimer's disease; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics; Behavioral Sciences; Biological Psychology; Development and progression; Disease Models, Animal; Exocytosis; Genetic aspects; Health aspects; Immunotherapy; Lysosomes; Medicine; Medicine & Public Health; Mice; Mice, Transgenic; Mutants; Neurodegenerative diseases; Neurofibrillary tangles; Neurological research; Neurosciences; Pathology; Pharmacotherapy; Protein folding; Protein seeding; Psychiatry; Species; Tau protein; Tau proteins; tau Proteins - genetics; Transcription factors; United States

Neurofibrillary tangles (NFTs) composed of hyperphosphorylated and misfolded tau protein are a pathological hallmark of Alzheimer’s disease and other tauopathy conditions. Tau is predominantly an intraneuronal protein but is also secreted in physiological and pathological conditions. The extracellul...