Suppression of the antiviral response by an influenza histone mimic

• Published in: Nature (London) Vol. 483; no. 7390; pp. 428 - 433
• Main Authors: Marazzi, Ivan, Ho, Jessica S. Y., Kim, Jaehoon, Manicassamy, Balaji, Dewell, Scott, Albrecht, Randy A., Seibert, Chris W., Schaefer, Uwe, Jeffrey, Kate L., Prinjha, Rab K., Lee, Kevin, García-Sastre, Adolfo, Roeder, Robert G., Tarakhovsky, Alexander
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.03.2012; Nature Publishing Group
• Subjects: 631/250/2499; 631/326/596; 692/699/255/1578; Amino Acid Sequence; Amino acids; Biological and medical sciences; Epigenetics; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation - immunology; Genomes; Histones - chemistry; Histones - metabolism; Humanities and Social Sciences; Humans; Influenza; Influenza A Virus, H3N2 Subtype - genetics; Influenza A Virus, H3N2 Subtype - metabolism; Influenza A Virus, H3N2 Subtype - pathogenicity; Influenza virus; Influenza, Human - genetics; Influenza, Human - immunology; Influenza, Human - pathology; Influenza, Human - virology; Microbiology; Molecular Mimicry; Molecular Sequence Data; multidisciplinary; Nuclear Proteins - antagonists & inhibitors; Nuclear Proteins - metabolism; Peptides; Protein Binding; Proteins; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; Science; Science (multidisciplinary); Transcription, Genetic - immunology; Viral Nonstructural Proteins - chemistry; Viral Nonstructural Proteins - metabolism; Virology; Virus; Deoxyribonucleoproteins; Basic protein; Orthomyxoviridae; Antiviral; Host agent relation; Histone; Influenzavirus; Nuclear protein

Viral infection is commonly associated with virus-driven hijacking of host proteins. Here we describe a novel mechanism by which influenza virus affects host cells through the interaction of influenza non-structural protein 1 (NS1) with the infected cell epigenome. We show that the NS1 protein of in...