Investigation of urine metabolome of BALB/c mouse infected with an avirulent strain of Toxoplasma gondii

The protozoan parasite Toxoplasma gondii is a major concern for human and animal health. Although the metabolic understanding of toxoplasmosis has increased in recent years, the analysis of metabolic alterations through noninvasive methodologies in biofluids remains limited. Here, we applied liquid...

Full description

Saved in:
Bibliographic Details
Published inParasites & vectors Vol. 15; no. 1; p. 271
Main Authors Zhou, Chun-Xue, Li, Ling-Yu, Huang, Cui-Qin, Guo, Xu-Dong, An, Xu-Dian, Luo, Fang-Fang, Cong, Wei
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 29.07.2022
BioMed Central
BMC
Subjects
amino acid metabolism
Amino acids
Analysis
Animal health
avirulent strains
Biomarkers
Care and treatment
Cell metabolism
Chromatography
Composition
Cysts
Diagnosis
Discriminant analysis
electrospray ionization mass spectrometry
Ethics
fatty acid metabolism
Fatty acids
Gas flow
Health aspects
Infections
Infectious diseases
Ionization
Laboratory animals
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Metabolism
Metabolites
metabolome
Metabolomics
mice
multivariate analysis
Multivariate statistical analysis
Nicotinamide
NMR
Nuclear magnetic resonance
Parasites
Pathogenesis
Physiology
principal component analysis
Principal components analysis
Protozoa
Scientific imaging
Statistical analysis
Statistical methods
tandem mass spectrometry
Toxoplasma gondii
Toxoplasmosis
Urine
China
Germany
Online AccessGet full text

Cover

Abstract The protozoan parasite Toxoplasma gondii is a major concern for human and animal health. Although the metabolic understanding of toxoplasmosis has increased in recent years, the analysis of metabolic alterations through noninvasive methodologies in biofluids remains limited. Here, we applied liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based metabolomics and multivariate statistical analysis to analyze BALB/c mouse urine collected from acutely infected, chronically infected and control subjects. In total, we identified 2065 and 1409 metabolites in the positive electrospray ionization (ESI +) mode and ESI - mode, respectively. Metabolomic patterns generated from principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) score plots clearly separated T. gondii-infected from uninfected urine samples. Metabolites with altered levels in urine from T. gondii-infected mice revealed changes in pathways related to amino acid metabolism, fatty acid metabolism, and nicotinate and nicotinamide metabolism. This is the first study to our knowledge on urine metabolic profiling of BALB/c mouse with T. gondii infection. The urine metabolome of infected mouse is distinctive and has value in the understanding of Toxoplasmosis pathogenesis and improvement of treatment.
AbstractList Abstract Background The protozoan parasite Toxoplasma gondii is a major concern for human and animal health. Although the metabolic understanding of toxoplasmosis has increased in recent years, the analysis of metabolic alterations through noninvasive methodologies in biofluids remains limited. Methods Here, we applied liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based metabolomics and multivariate statistical analysis to analyze BALB/c mouse urine collected from acutely infected, chronically infected and control subjects. Results In total, we identified 2065 and 1409 metabolites in the positive electrospray ionization (ESI +) mode and ESI − mode, respectively. Metabolomic patterns generated from principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) score plots clearly separated T. gondii-infected from uninfected urine samples. Metabolites with altered levels in urine from T. gondii-infected mice revealed changes in pathways related to amino acid metabolism, fatty acid metabolism, and nicotinate and nicotinamide metabolism. Conclusions This is the first study to our knowledge on urine metabolic profiling of BALB/c mouse with T. gondii infection. The urine metabolome of infected mouse is distinctive and has value in the understanding of Toxoplasmosis pathogenesis and improvement of treatment. Graphical Abstract
Background The protozoan parasite Toxoplasma gondii is a major concern for human and animal health. Although the metabolic understanding of toxoplasmosis has increased in recent years, the analysis of metabolic alterations through noninvasive methodologies in biofluids remains limited. Methods Here, we applied liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based metabolomics and multivariate statistical analysis to analyze BALB/c mouse urine collected from acutely infected, chronically infected and control subjects. Results In total, we identified 2065 and 1409 metabolites in the positive electrospray ionization (ESI +) mode and ESI − mode, respectively. Metabolomic patterns generated from principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) score plots clearly separated T. gondii-infected from uninfected urine samples. Metabolites with altered levels in urine from T. gondii-infected mice revealed changes in pathways related to amino acid metabolism, fatty acid metabolism, and nicotinate and nicotinamide metabolism. Conclusions This is the first study to our knowledge on urine metabolic profiling of BALB/c mouse with T. gondii infection. The urine metabolome of infected mouse is distinctive and has value in the understanding of Toxoplasmosis pathogenesis and improvement of treatment.
The protozoan parasite Toxoplasma gondii is a major concern for human and animal health. Although the metabolic understanding of toxoplasmosis has increased in recent years, the analysis of metabolic alterations through noninvasive methodologies in biofluids remains limited. Here, we applied liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based metabolomics and multivariate statistical analysis to analyze BALB/c mouse urine collected from acutely infected, chronically infected and control subjects. In total, we identified 2065 and 1409 metabolites in the positive electrospray ionization (ESI +) mode and ESI - mode, respectively. Metabolomic patterns generated from principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) score plots clearly separated T. gondii-infected from uninfected urine samples. Metabolites with altered levels in urine from T. gondii-infected mice revealed changes in pathways related to amino acid metabolism, fatty acid metabolism, and nicotinate and nicotinamide metabolism. This is the first study to our knowledge on urine metabolic profiling of BALB/c mouse with T. gondii infection. The urine metabolome of infected mouse is distinctive and has value in the understanding of Toxoplasmosis pathogenesis and improvement of treatment.
The protozoan parasite Toxoplasma gondii is a major concern for human and animal health. Although the metabolic understanding of toxoplasmosis has increased in recent years, the analysis of metabolic alterations through noninvasive methodologies in biofluids remains limited.BACKGROUNDThe protozoan parasite Toxoplasma gondii is a major concern for human and animal health. Although the metabolic understanding of toxoplasmosis has increased in recent years, the analysis of metabolic alterations through noninvasive methodologies in biofluids remains limited.Here, we applied liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based metabolomics and multivariate statistical analysis to analyze BALB/c mouse urine collected from acutely infected, chronically infected and control subjects.METHODSHere, we applied liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based metabolomics and multivariate statistical analysis to analyze BALB/c mouse urine collected from acutely infected, chronically infected and control subjects.In total, we identified 2065 and 1409 metabolites in the positive electrospray ionization (ESI +) mode and ESI - mode, respectively. Metabolomic patterns generated from principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) score plots clearly separated T. gondii-infected from uninfected urine samples. Metabolites with altered levels in urine from T. gondii-infected mice revealed changes in pathways related to amino acid metabolism, fatty acid metabolism, and nicotinate and nicotinamide metabolism.RESULTSIn total, we identified 2065 and 1409 metabolites in the positive electrospray ionization (ESI +) mode and ESI - mode, respectively. Metabolomic patterns generated from principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) score plots clearly separated T. gondii-infected from uninfected urine samples. Metabolites with altered levels in urine from T. gondii-infected mice revealed changes in pathways related to amino acid metabolism, fatty acid metabolism, and nicotinate and nicotinamide metabolism.This is the first study to our knowledge on urine metabolic profiling of BALB/c mouse with T. gondii infection. The urine metabolome of infected mouse is distinctive and has value in the understanding of Toxoplasmosis pathogenesis and improvement of treatment.CONCLUSIONSThis is the first study to our knowledge on urine metabolic profiling of BALB/c mouse with T. gondii infection. The urine metabolome of infected mouse is distinctive and has value in the understanding of Toxoplasmosis pathogenesis and improvement of treatment.
Background The protozoan parasite Toxoplasma gondii is a major concern for human and animal health. Although the metabolic understanding of toxoplasmosis has increased in recent years, the analysis of metabolic alterations through noninvasive methodologies in biofluids remains limited. Methods Here, we applied liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based metabolomics and multivariate statistical analysis to analyze BALB/c mouse urine collected from acutely infected, chronically infected and control subjects. Results In total, we identified 2065 and 1409 metabolites in the positive electrospray ionization (ESI +) mode and ESI - mode, respectively. Metabolomic patterns generated from principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) score plots clearly separated T. gondii-infected from uninfected urine samples. Metabolites with altered levels in urine from T. gondii-infected mice revealed changes in pathways related to amino acid metabolism, fatty acid metabolism, and nicotinate and nicotinamide metabolism. Conclusions This is the first study to our knowledge on urine metabolic profiling of BALB/c mouse with T. gondii infection. The urine metabolome of infected mouse is distinctive and has value in the understanding of Toxoplasmosis pathogenesis and improvement of treatment. Graphical Keywords: Toxoplasma gondii, Urine, Mass spectrometry, Metabolomics
ArticleNumber 271
Audience Academic
Author Luo, Fang-Fang
Li, Ling-Yu
Cong, Wei
Huang, Cui-Qin
Guo, Xu-Dong
Zhou, Chun-Xue
An, Xu-Dian
Author_xml – sequence: 1
  givenname: Chun-Xue
  surname: Zhou
  fullname: Zhou, Chun-Xue
– sequence: 2
  givenname: Ling-Yu
  surname: Li
  fullname: Li, Ling-Yu
– sequence: 3
  givenname: Cui-Qin
  surname: Huang
  fullname: Huang, Cui-Qin
– sequence: 4
  givenname: Xu-Dong
  surname: Guo
  fullname: Guo, Xu-Dong
– sequence: 5
  givenname: Xu-Dian
  surname: An
  fullname: An, Xu-Dian
– sequence: 6
  givenname: Fang-Fang
  surname: Luo
  fullname: Luo, Fang-Fang
– sequence: 7
  givenname: Wei
  surname: Cong
  fullname: Cong, Wei
BookMark eNqFkktv1DAUhSNURB_wB1hFYgOLtH7H3iC1FY-RRkKCsrYcx854lNiD7Qzl3-OZKYKpECgLR9fnfPa9PufViQ_eVNVLCC4h5OwqQQxa2ACEGkAJ4A16Up3BlrIGY0BP_vg_rc5TWgPAgKDsWXWKqQCMCXpWrRZ-a1J2g8ou-DrYeo7Om3oyWXVhDJPZ1W6ulzdXup7CnEztvDU6m77-7vKqVr5WWxfn0fhcpxyV21Puwn3YjCpNqh6C7517Xj21akzmxcN6UX19_-7u9mOz_PRhcXu9bDTFbW4MaA1tNewg6HrddYi2lmFFNSdcMU4oFBjYXjFNWq4EYRYg0FouFO-EJgxfVIsDtw9qLTfRTSr-kEE5uS-EOEgVs9OjkcIiAlFLDEKYAAA7xiiAnPa9sUS0orDeHlibuZtMr0uLUY1H0OMd71ZyCFspMOaUkgJ4_QCI4dtc5iwnl7QZR-VNmaVELeSIM8DZ_6VMME45E7trvXokXYc5-jLVAgQEwtIP_q0aVOm1PFooV9Q7qLwux5aDGeRFdfkXVfl6Mzld8mZdqR8Z3hwZiiab-zyoOSW5-PL5WMsPWh1DStFYqV3eB22Xk1FCIHdBlocgyxJkuQ-yRMWKHll_Tf0fpp_Qb_Kj
CitedBy_id crossref_primary_10_1038_s41598_024_81003_y
crossref_primary_10_1007_s10142_023_00995_4
Cites_doi 10.1038/srep19557
10.1016/j.parint.2020.102239
10.1186/s13071-021-04713-6
10.1186/s13071-015-0902-6
10.1186/s13071-019-3623-4
10.1371/journal.ppat.1008432
10.1074/mcp.M115.052381
10.1021/acs.jproteome.7b00206
10.1111/jphp.12081
10.1046/j.1469-0691.2002.00485.x
10.1038/srep22525
10.1016/j.cmet.2020.06.016
10.1093/infdis/157.1.1
10.1038/s41598-018-29713-y
10.1016/S0020-7519(00)00124-7
10.1016/j.ejmech.2019.111711
10.3389/fmicb.2017.02612
10.1016/j.ijpara.2020.11.001
10.1289/EHP4713
10.1007/s00216-013-6934-x
10.1021/pr300337s
10.1046/j.1537-2995.1975.15275122804.x
10.1186/1475-2875-9-110
10.1016/j.jpba.2020.113376
10.1093/nar/gkab382
10.3389/fmicb.2020.626183
10.1038/nri3598
10.1016/j.jpba.2011.11.010
10.1021/pr100835s
10.1016/j.amjmed.2004.08.023
10.1186/s12876-018-0842-7
10.1016/j.ijpara.2009.02.004
10.1016/j.celrep.2021.110271
10.3389/fimmu.2020.569727
10.1111/j.1440-1797.2010.01387.x
10.1159/000058406
10.1542/peds.2016-3860
10.3390/vaccines9050413
ContentType Journal Article
Copyright COPYRIGHT 2022 BioMed Central Ltd.
2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2022. The Author(s).
The Author(s) 2022
Copyright_xml – notice: COPYRIGHT 2022 BioMed Central Ltd.
– notice: 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2022. The Author(s).
– notice: The Author(s) 2022
DBID AAYXX
CITATION
ISR
3V.
7SN
7SS
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
C1K
CCPQU
COVID
DWQXO
F1W
FYUFA
GHDGH
H95
K9.
L.G
M0S
M1P
M7N
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
7S9
L.6
5PM
DOA
DOI 10.1186/s13071-022-05408-2
DatabaseName CrossRef
Gale In Context: Science
ProQuest Central (Corporate)
Ecology Abstracts
Entomology Abstracts (Full archive)
ProQuest - Health & Medical Complete保健、医学与药学数据库
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
Environmental Sciences and Pollution Management
ProQuest One Community College
Coronavirus Research Database
ProQuest Central Korea
ASFA: Aquatic Sciences and Fisheries Abstracts
Health Research Premium Collection
Health Research Premium Collection (Alumni)
Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources
ProQuest Health & Medical Complete (Alumni)
Aquatic Science & Fisheries Abstracts (ASFA) Professional
ProQuest Health & Medical Collection
Medical Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals (DOAJ) (Open Access)
DatabaseTitle CrossRef
Publicly Available Content Database
Aquatic Science & Fisheries Abstracts (ASFA) Professional
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Algology Mycology and Protozoology Abstracts (Microbiology C)
Health & Medical Research Collection
Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
Coronavirus Research Database
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ASFA: Aquatic Sciences and Fisheries Abstracts
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList
Publicly Available Content Database


MEDLINE - Academic
AGRICOLA
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Zoology
EISSN 1756-3305
EndPage 271
ExternalDocumentID oai_doaj_org_article_9f241274e2234001b6650185ddef4979
PMC9338554
A718182618
10_1186_s13071_022_05408_2
GeographicLocations China
Germany
GeographicLocations_xml – name: China
– name: Germany
GrantInformation_xml – fundername: ;
  grantid: 82002161
GroupedDBID ---
0R~
123
29O
2WC
2XV
53G
5VS
7X7
88E
8FI
8FJ
AAFWJ
AAJSJ
AASML
AAYXX
ABDBF
ABUWG
ACGFS
ACIHN
ACPRK
ACUHS
ADBBV
ADRAZ
ADUKV
AEAQA
AENEX
AFKRA
AFPKN
AFRAH
AHBYD
AHMBA
AHYZX
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BCNDV
BENPR
BFQNJ
BMC
BPHCQ
BVXVI
C6C
CCPQU
CITATION
CS3
DIK
DU5
E3Z
EBD
EBLON
EBS
ECGQY
EMOBN
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
HMCUK
HYE
IAO
IHR
INH
INR
ISR
ITC
KQ8
M1P
M48
M~E
O5R
O5S
OK1
OVT
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
RBZ
RNS
ROL
RPM
RSV
SBL
SOJ
SV3
TR2
TUS
UKHRP
~8M
PMFND
3V.
7SN
7SS
7XB
8FK
AZQEC
C1K
COVID
DWQXO
F1W
H95
K9.
L.G
M7N
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
PRINS
7X8
7S9
L.6
5PM
PUEGO
ID FETCH-LOGICAL-c537t-e07e57c1b10bdcbb257f63a5c848a68451930fda6c478a946f0207f89a8b9c463
IEDL.DBID 7X7
ISSN 1756-3305
IngestDate Wed Aug 27 01:17:56 EDT 2025
Thu Aug 21 13:13:21 EDT 2025
Fri Jul 11 01:46:42 EDT 2025
Fri Jul 11 11:25:42 EDT 2025
Fri Jul 25 22:57:31 EDT 2025
Tue Jun 17 21:37:24 EDT 2025
Tue Jun 10 20:08:11 EDT 2025
Fri Jun 27 05:02:02 EDT 2025
Tue Jul 01 00:54:11 EDT 2025
Thu Apr 24 23:07:18 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c537t-e07e57c1b10bdcbb257f63a5c848a68451930fda6c478a946f0207f89a8b9c463
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://www.proquest.com/docview/2704112233?pq-origsite=%requestingapplication%
PMID 35906695
PQID 2704112233
PQPubID 55241
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_9f241274e2234001b6650185ddef4979
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9338554
proquest_miscellaneous_2718286086
proquest_miscellaneous_2696858699
proquest_journals_2704112233
gale_infotracmisc_A718182618
gale_infotracacademiconefile_A718182618
gale_incontextgauss_ISR_A718182618
crossref_citationtrail_10_1186_s13071_022_05408_2
crossref_primary_10_1186_s13071_022_05408_2
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-07-29
PublicationDateYYYYMMDD 2022-07-29
PublicationDate_xml – month: 07
  year: 2022
  text: 2022-07-29
  day: 29
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
PublicationTitle Parasites & vectors
PublicationYear 2022
Publisher BioMed Central Ltd
BioMed Central
BMC
Publisher_xml – name: BioMed Central Ltd
– name: BioMed Central
– name: BMC
References S Ren (5408_CR23) 2016; 15
LA Sanni (5408_CR40) 1998; 152
K Haug (5408_CR22) 2020; 48
Z Pang (5408_CR21) 2021; 49
NC Smith (5408_CR3) 2021; 51
KB Chu (5408_CR8) 2021; 9
Z Liu (5408_CR38) 2018; 18
BJ Luft (5408_CR6) 1988; 157
N Nagaraj (5408_CR26) 2011; 10
T Zhao (5408_CR31) 2012; 60
YA Maldonado (5408_CR10) 2017; 139
X Wang (5408_CR37) 2012; 11
Y Hu (5408_CR41) 2020; 11
RM Loyo (5408_CR17) 2021; 80
GJ Roth (5408_CR34) 1975; 15
CX Zhou (5408_CR14) 2016; 6
K Doi (5408_CR36) 2011; 16
JW Song (5408_CR24) 2020; 32
WJ Olson (5408_CR13) 2020; 16
Y Fan (5408_CR33) 2020; 188
Q Liu (5408_CR11) 2015; 8
D Hill (5408_CR5) 2002; 8
A Pegalajar-Jurado (5408_CR16) 2018; 8
X Bi (5408_CR15) 2022; 38
F Yarovinsky (5408_CR28) 2014; 14
LM Weiss (5408_CR4) 2009; 39
LL Cui (5408_CR18) 2021; 14
Q Feng (5408_CR20) 2016; 6
BR Pinho (5408_CR32) 2013; 65
J Yu (5408_CR30) 2017; 16
Y Deng (5408_CR9) 2019; 183
A Basant (5408_CR39) 2010; 9
EM Slominska (5408_CR35) 2002; 91
DK Barupal (5408_CR29) 2019; 127
AM Tenter (5408_CR1) 2000; 30
P Emond (5408_CR19) 2013; 405
J Ma (5408_CR12) 2019; 12
X Yu (5408_CR25) 2021; 11
CX Zhou (5408_CR27) 2018; 8
HM Elsheikha (5408_CR2) 2020; 34
JD Kravetz (5408_CR7) 2005; 118
References_xml – volume: 34
  start-page: e00115
  year: 2020
  ident: 5408_CR2
  publication-title: Clin Microbiol
– volume: 6
  start-page: 19557
  year: 2016
  ident: 5408_CR14
  publication-title: Sci Rep
  doi: 10.1038/srep19557
– volume: 80
  start-page: 102239
  year: 2021
  ident: 5408_CR17
  publication-title: Parasitol Int
  doi: 10.1016/j.parint.2020.102239
– volume: 14
  start-page: 211
  year: 2021
  ident: 5408_CR18
  publication-title: Parasit Vectors
  doi: 10.1186/s13071-021-04713-6
– volume: 8
  start-page: 292
  year: 2015
  ident: 5408_CR11
  publication-title: Parasit Vectors
  doi: 10.1186/s13071-015-0902-6
– volume: 12
  start-page: 373
  year: 2019
  ident: 5408_CR12
  publication-title: Parasit Vectors
  doi: 10.1186/s13071-019-3623-4
– volume: 16
  start-page: e1008432
  year: 2020
  ident: 5408_CR13
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1008432
– volume: 15
  start-page: 154
  year: 2016
  ident: 5408_CR23
  publication-title: Mol Cell Proteomics
  doi: 10.1074/mcp.M115.052381
– volume: 16
  start-page: 3219
  year: 2017
  ident: 5408_CR30
  publication-title: J Proteome Res
  doi: 10.1021/acs.jproteome.7b00206
– volume: 65
  start-page: 1681
  year: 2013
  ident: 5408_CR32
  publication-title: J Pharm Pharmacol
  doi: 10.1111/jphp.12081
– volume: 8
  start-page: 634
  year: 2002
  ident: 5408_CR5
  publication-title: Clin Microbiol Infect
  doi: 10.1046/j.1469-0691.2002.00485.x
– volume: 6
  start-page: 22525
  year: 2016
  ident: 5408_CR20
  publication-title: Sci Rep
  doi: 10.1038/srep22525
– volume: 32
  start-page: 188
  year: 2020
  ident: 5408_CR24
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2020.06.016
– volume: 157
  start-page: 1
  year: 1988
  ident: 5408_CR6
  publication-title: J Infect Dis
  doi: 10.1093/infdis/157.1.1
– volume: 8
  start-page: 12204
  year: 2018
  ident: 5408_CR16
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-29713-y
– volume: 30
  start-page: 1217
  year: 2000
  ident: 5408_CR1
  publication-title: Int J Parasitol
  doi: 10.1016/S0020-7519(00)00124-7
– volume: 183
  start-page: 111711
  year: 2019
  ident: 5408_CR9
  publication-title: Eur J Med Chem
  doi: 10.1016/j.ejmech.2019.111711
– volume: 152
  start-page: 611
  year: 1998
  ident: 5408_CR40
  publication-title: Am J Pathol
– volume: 48
  start-page: D440
  year: 2020
  ident: 5408_CR22
  publication-title: Nucleic Acids Res
– volume: 8
  start-page: 2612
  year: 2018
  ident: 5408_CR27
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2017.02612
– volume: 51
  start-page: 95
  year: 2021
  ident: 5408_CR3
  publication-title: Int J Parasitol
  doi: 10.1016/j.ijpara.2020.11.001
– volume: 127
  start-page: 97008
  year: 2019
  ident: 5408_CR29
  publication-title: Environ Health Perspect
  doi: 10.1289/EHP4713
– volume: 405
  start-page: 5291
  year: 2013
  ident: 5408_CR19
  publication-title: Anal Bioanal Chem
  doi: 10.1007/s00216-013-6934-x
– volume: 11
  start-page: 3838
  year: 2012
  ident: 5408_CR37
  publication-title: J Proteome Res
  doi: 10.1021/pr300337s
– volume: 15
  start-page: 116
  year: 1975
  ident: 5408_CR34
  publication-title: Transfusion
  doi: 10.1046/j.1537-2995.1975.15275122804.x
– volume: 9
  start-page: 110
  year: 2010
  ident: 5408_CR39
  publication-title: Malar J
  doi: 10.1186/1475-2875-9-110
– volume: 188
  start-page: 113376
  year: 2020
  ident: 5408_CR33
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2020.113376
– volume: 49
  start-page: W388
  year: 2021
  ident: 5408_CR21
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkab382
– volume: 11
  start-page: 626183
  year: 2021
  ident: 5408_CR25
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2020.626183
– volume: 14
  start-page: 109
  year: 2014
  ident: 5408_CR28
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3598
– volume: 60
  start-page: 32
  year: 2012
  ident: 5408_CR31
  publication-title: J Pharm Biomed Anal
  doi: 10.1016/j.jpba.2011.11.010
– volume: 10
  start-page: 637
  year: 2011
  ident: 5408_CR26
  publication-title: J Proteome Res
  doi: 10.1021/pr100835s
– volume: 118
  start-page: 212
  year: 2005
  ident: 5408_CR7
  publication-title: The Am J Med
  doi: 10.1016/j.amjmed.2004.08.023
– volume: 18
  start-page: 112
  year: 2018
  ident: 5408_CR38
  publication-title: BMC Gastroenterol
  doi: 10.1186/s12876-018-0842-7
– volume: 39
  start-page: 895
  year: 2009
  ident: 5408_CR4
  publication-title: Int J Parasitol
  doi: 10.1016/j.ijpara.2009.02.004
– volume: 38
  start-page: 110271
  year: 2022
  ident: 5408_CR15
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2021.110271
– volume: 11
  start-page: 569727
  year: 2020
  ident: 5408_CR41
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2020.569727
– volume: 16
  start-page: 304
  year: 2011
  ident: 5408_CR36
  publication-title: Nephrology (Carlton)
  doi: 10.1111/j.1440-1797.2010.01387.x
– volume: 91
  start-page: 286
  year: 2002
  ident: 5408_CR35
  publication-title: Nephron
  doi: 10.1159/000058406
– volume: 139
  start-page: e20163860
  year: 2017
  ident: 5408_CR10
  publication-title: Pediatrics
  doi: 10.1542/peds.2016-3860
– volume: 9
  start-page: 413
  year: 2021
  ident: 5408_CR8
  publication-title: Vaccines (Basel)
  doi: 10.3390/vaccines9050413
SSID ssj0060956
Score 2.3138177
Snippet The protozoan parasite Toxoplasma gondii is a major concern for human and animal health. Although the metabolic understanding of toxoplasmosis has increased in...
Background The protozoan parasite Toxoplasma gondii is a major concern for human and animal health. Although the metabolic understanding of toxoplasmosis has...
BACKGROUND: The protozoan parasite Toxoplasma gondii is a major concern for human and animal health. Although the metabolic understanding of toxoplasmosis has...
Abstract Background The protozoan parasite Toxoplasma gondii is a major concern for human and animal health. Although the metabolic understanding of...
SourceID doaj
pubmedcentral
proquest
gale
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Enrichment Source
Index Database
StartPage 271
SubjectTerms amino acid metabolism
Amino acids
Analysis
Animal health
avirulent strains
Biomarkers
Care and treatment
Cell metabolism
Chromatography
Composition
Cysts
Diagnosis
Discriminant analysis
electrospray ionization mass spectrometry
Ethics
fatty acid metabolism
Fatty acids
Gas flow
Health aspects
Infections
Infectious diseases
Ionization
Laboratory animals
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Metabolism
Metabolites
metabolome
Metabolomics
mice
multivariate analysis
Multivariate statistical analysis
Nicotinamide
NMR
Nuclear magnetic resonance
Parasites
Pathogenesis
Physiology
principal component analysis
Principal components analysis
Protozoa
Scientific imaging
Statistical analysis
Statistical methods
tandem mass spectrometry
Toxoplasma gondii
Toxoplasmosis
Urine
SummonAdditionalLinks – databaseName: Directory of Open Access Journals (DOAJ) (Open Access)
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3di9QwEA9yIPgifmK9U6IIPkjZtknz8bgrHqeoD3oHhy8hSZO7hdv2uO6Kf74zaXfZKpwvviYTms5HZibM_ELIG-atclUMecNFnXPNXK5t8HkZCxaclKFy2Jz85as4OeOfzuvzvae-sCZsgAceGDfTEXwMpE4B_BjoW-mEQAy6Gswyci1T6x74vG0yNZzBiKImti0ySsx6OKklpM2QeGGIAroxcUMJrf_vM_nPOsk9x3P8gNwfI0Y6H3b6kNwJ7SNy90eX7sMfk8s9pIyupV2keH8e6CqsQb5X3Srg2GL-eTHzFPP8QIcCrNBQvISltqX25_Jmg-6H9unJCFxx2v3qriG0Xll60bXNcvmEnB1_OH1_ko_PJ-S-ZnKdh0KGWvrSlYVrvHNgnFEwW3vFlRUKcWVYERsrPJfKai4ihI4yKg3S054L9pQctF0bnhHqbYW4eDJo4XhTFFapyBmLIWoZC6cyUm65afyILY77vTIpx1DCDBIwIAGTJGCqjLzbrbkekDVupV6gkHaUiIqdBkBXzKgr5l-6kpHXKGKDuBctFtZc2E3fm4_fv5k5-GhMtUr4l7cjUezgH7wd-xSAEwiVNaE8mlCCYfrp9FaTzHgw9KaSBYcQt2IsI69207gSi93aAGpgKgQsqpXQ-hYa-AzIBBLSjMiJlk5YNJ1pl5cJQFwzhtWJz_8HTw_JvSrZlcwrfUQO1jeb8ALitLV7mUzyN79jN6o
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELZKERIXxFOkFGQQEgcUmsSOHweEdhFVQZQDdKWKi2U79nal3aTsA5V_z0w2u2qg2ms8Vhx_M_aMM_6GkNfMW-WKGNKKizLlmrlU2-DTPGYsOClD4fBy8uk3cTLiX87L8z2yKXfUTeDixtAO60mN5tN3V7_-fACDf98avBJHC1iHJQTFEFahAwLI3yK3YWeSWNHglG__KiC3mthcnLmxX29zajn8_1-p_82evLYdHd8n9zo_kg7WwD8ge6F-SO78bNpT8kfk4hp_RlPTJlI8VQ90FpaA-rSZBXw2HHwdHnmK0X-g67SsUFE8mqW2pvb3ZL7CTYku2kIS2OOsuWouweGeWTpu6moyeUxGx5_OPp6kXVGF1JdMLtOQyVBKn7s8c5V3Dkw2CmZLr7iyQiHbDMtiZYXnUlnNRQSHUkalAVPtuWBPyH7d1OEpod4WyJYngxaOV1lmlYqcsRiiljFzKiH5ZjaN7xjHcbxT00YeSpg1AgYQMC0CpkjI222fyzXfxk7pIYK0lUSu7PZBMx-bzvSMjqALEHwH8IRgxcodjDkDNwUW9si11Al5hRAbZMOoMd1mbFeLhfn847sZwM6NAVgO3_KmE4oNfIO33e0FmAkk0OpJHvYkwVx9v3mjSWaj7aaQGQfHt2AsIS-3zdgTU-DqAGpgCqQxKpXQeocMvAYwgTA1IbKnpb0p6rfUk4uWVlwzhjmLB7sH-IzcLVqLkWmhD8n-cr4Kz8EvW7oXrbH9BSPPM_w
  priority: 102
  providerName: Scholars Portal
Title Investigation of urine metabolome of BALB/c mouse infected with an avirulent strain of Toxoplasma gondii
URI https://www.proquest.com/docview/2704112233
https://www.proquest.com/docview/2696858699
https://www.proquest.com/docview/2718286086
https://pubmed.ncbi.nlm.nih.gov/PMC9338554
https://doaj.org/article/9f241274e2234001b6650185ddef4979
Volume 15
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9swEBdby2AvY58sXRe8MdjDMLEtWR9PIxktXVjL6AeEvQhJltJAY2dxMvbn785xsnqDvNhgnbCs-9Dd-fQTIR-oM9JmwccF43nMFLWxMt7FaUiot0L4zOLm5PMLfnbDxpN80ibc6rascmsTG0NdVA5z5INMJAx8g4zSz4ufMZ4ahX9X2yM0HpJDhC5DqRaTXcCFWGp8u1FG8kEN9lpA8AzhFzoqICGdxajB7P_fMv9bLXlv-Tl9Sp60fmM03DD6GXngy-fk0Y-qyYq_ILf38DKqMqpChFl0H839Crh8V809PhsNv40GLsJo30ebMixfRJiKjUwZmV-z5RoXoahuDo7AHtfV72oBDvbcRNOqLGazl-Tm9OT6y1ncHqIQu5yKVewT4XPhUpsmtnDWgooGTk3uJJOGS0SXoUkoDHdMSKMYD-BAiiAV8FA5xukrclBWpX9NImcyRMcTXnHLiiQxUgZGafBBiZBY2SPpdja1axHGcbx3uok0JNcbDmjggG44oLMe-bTrs9jga-ylHiGTdpSIjd08qJZT3aqaVgG8Egi2PQgLWKjUwpgTcEvAkAemhOqR98hijegXJZbXTM26rvXXq0s9hJUaA64UvuVjSxQq-AZn2t0KMBMImNWhPO5Qgnq6bvNWknRrHmr9V5h75N2uGXtiyVvpQQx0hrBFueRK7aGB1wBPICztEdGR0s4UdVvK2W0DI64oxRrFo_0DfEMeZ43GiDhTx-RgtVz7t-CHrWy_UbY-ORwOx1djuI9OLr5f9pusBlzPmfwD-lo1ww
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Nb9MwFLfGEIIL4lMUBhgE4oCiJnESxweEWmBqWbcDdFLFxdiO3VVak9K0fPxT_I28lyZlAam3XePnxPb7dp5_JuQFMyrVobNeFiWxFwmmPaGs8QLnM6s5t6HGw8nHJ8ngNPo4iSd75HdzFgbLKhubWBnqrDC4R94NuR9BbBAy9nbxzcNbo_DvanOFxkYsjuyvH5CylW-G74G_L8Pw8MP43cCrbxXwTMz4yrM-tzE3gQ58nRmtQWZdwlRs0ihVSYpwK8x3mUpMxFMlosRBRMVdKmBSwkQJg_deIVfB8fqY7PHJNsFD7LakOZiTJt0S_AOHZB3SPQyMQCJbzq-6I-B_T_BvdeYFd3d4i9ys41Ta2wjWbbJn8zvk2pei2oW_S84u4HMUOS0cxV17S-d2BVJ1XswtPuv3Rv2uobi7YOmm7MtmFLd-qcqp-j5brtHp0bK6qAJ7jIufxQIC-rmi0yLPZrN75PRSlvc-2c-L3D4g1KgQ0fi4FYmOMt9Xaeoixpx1gjtfpx0SNKspTY1ojuM9l1VmkyZywwEJHJAVB2TYIa-3fRYbPI-d1H1k0pYSsbirB8VyKmvVlsJBFATJvQXhBIsYaBizD2EQOA4XCS465DmyWCLaRo7lPFO1Lks5_PxJ9iAywAQvgLm8qolcAXMwqj4dASuBAF0tyoMWJZgD025uJEnW5qiUf5WnQ55tm7EnltjlFsRAhgiTFKeJEDto4DPAE0iDO4S3pLS1RO2WfHZWwZYLxrAm8uHuAT4l1wfj45EcDU-OHpEbYaU93AvFAdlfLdf2McSAK_2kUjxKvl62pv8BWddtLQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Investigation+of+urine+metabolome+of+BALB%2Fc+mouse+infected+with+an+avirulent+strain+of+Toxoplasma+gondii&rft.jtitle=Parasites+%26+vectors&rft.au=Chun-Xue%2C+Zhou&rft.au=Ling-Yu%2C+Li&rft.au=Cui-Qin%2C+Huang&rft.au=Xu-Dong%2C+Guo&rft.date=2022-07-29&rft.pub=BioMed+Central&rft.eissn=1756-3305&rft.volume=15&rft.spage=1&rft_id=info:doi/10.1186%2Fs13071-022-05408-2
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1756-3305&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1756-3305&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1756-3305&client=summon