Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway

• Published in: Oxidative medicine and cellular longevity Vol. 2019; no. 2019; pp. 1 - 14
• Main Authors: Nakamura, Celso Vataru, Ueda-Nakamura, Tânia, Truiti, Maria da Conceição Torrado, Silva, Sueli de Oliveira, Daré, Regina G., Ratti, Bianca Altrão, Oliveira, Mariana M., Auzely, Rachel
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2019; Hindawi; Hindawi Limited
• Subjects: Acids; Animals; Antioxidants - pharmacology; Apoptosis; Apoptosis - drug effects; Apoptosis - radiation effects; Caffeic Acids - chemistry; Caffeic Acids - pharmacology; Cell Line; Cell Survival - drug effects; Cell Survival - radiation effects; Cytoprotection - drug effects; Cytoprotection - radiation effects; Ethanol; Fibroblasts; Kinases; Laboratories; Lipid peroxidation; Lipid Peroxidation - drug effects; Lipid Peroxidation - radiation effects; MAP Kinase Signaling System - drug effects; MAP Kinase Signaling System - radiation effects; Matrix Metalloproteinase 1 - metabolism; Membrane Potential, Mitochondrial - drug effects; Membrane Potential, Mitochondrial - radiation effects; Mice; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - radiation effects; p38 Mitogen-Activated Protein Kinases - metabolism; Phosphorylation - drug effects; Phosphorylation - radiation effects; Polyphenols; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Signal transduction; Ultraviolet Rays; United States > US; Grand Island New York

Chronic UVB exposure promotes oxidative stress, directly causes molecular damage, and induces aging-related signal transduction, leading to skin photoaging. Dihydrocaffeic acid (DHCA) is a phenolic compound with potential antioxidant capacity and is thus a promising compound for the prevention of UV...