Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway

Chronic UVB exposure promotes oxidative stress, directly causes molecular damage, and induces aging-related signal transduction, leading to skin photoaging. Dihydrocaffeic acid (DHCA) is a phenolic compound with potential antioxidant capacity and is thus a promising compound for the prevention of UV...

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Published inOxidative medicine and cellular longevity Vol. 2019; no. 2019; pp. 1 - 14
Main Authors Nakamura, Celso Vataru, Ueda-Nakamura, Tânia, Truiti, Maria da Conceição Torrado, Silva, Sueli de Oliveira, Daré, Regina G., Ratti, Bianca Altrão, Oliveira, Mariana M., Auzely, Rachel
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Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2019
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Abstract Chronic UVB exposure promotes oxidative stress, directly causes molecular damage, and induces aging-related signal transduction, leading to skin photoaging. Dihydrocaffeic acid (DHCA) is a phenolic compound with potential antioxidant capacity and is thus a promising compound for the prevention of UVB-induced skin photodamage. The aim of this study was to evaluate the antioxidant and protective effect of DHCA against oxidative stress, apoptosis, and matrix metalloproteinase (MMP) expression via the mitogen-activated protein kinase (MAPK) signaling pathway on L929 fibroblasts irradiated with UVB. DHCA exhibited high antioxidant capacity on 2,2-diphenyl-1-picrylhydrazyl (DPPH•), 2,2-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS•+), and xanthine/luminol/xanthine oxidase (XOD) assays and reduced UVB-induced cell death in the neutral red assay. DHCA also modulated oxidative stress by decreasing intracellular reactive oxygen species (ROS) and extracellular hydrogen peroxide (H2O2) production, enhancing catalase (CAT) and superoxide dismutase (SOD) activities and reduced glutathione (GSH) levels. Hence, cellular damage was attenuated by DHCA, including lipid peroxidation, apoptosis/necrosis and its markers (loss of mitochondria membrane potential, DNA condensation, and cleaved caspase 9 expression), and MMP-1 expression. Furthermore, DHCA reduced the phosphorylation of MAPK p38. These findings suggest that DHCA can be used in the development of skin care products to prevent UVB-induced skin damage.
AbstractList Chronic UVB exposure promotes oxidative stress, directly causes molecular damage, and induces aging-related signal transduction, leading to skin photoaging. Dihydrocaffeic acid (DHCA) is a phenolic compound with potential antioxidant capacity and is thus a promising compound for the prevention of UVB-induced skin photodamage. The aim of this study was to evaluate the antioxidant and protective effect of DHCA against oxidative stress, apoptosis, and matrix metalloproteinase (MMP) expression via the mitogen-activated protein kinase (MAPK) signaling pathway on L929 fibroblasts irradiated with UVB. DHCA exhibited high antioxidant capacity on 2,2-diphenyl-1-picrylhydrazyl (DPPH • ), 2,2-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS •+ ), and xanthine/luminol/xanthine oxidase (XOD) assays and reduced UVB-induced cell death in the neutral red assay. DHCA also modulated oxidative stress by decreasing intracellular reactive oxygen species (ROS) and extracellular hydrogen peroxide (H 2 O 2 ) production, enhancing catalase (CAT) and superoxide dismutase (SOD) activities and reduced glutathione (GSH) levels. Hence, cellular damage was attenuated by DHCA, including lipid peroxidation, apoptosis/necrosis and its markers (loss of mitochondria membrane potential, DNA condensation, and cleaved caspase 9 expression), and MMP-1 expression. Furthermore, DHCA reduced the phosphorylation of MAPK p38. These findings suggest that DHCA can be used in the development of skin care products to prevent UVB-induced skin damage.
Chronic UVB exposure promotes oxidative stress, directly causes molecular damage, and induces aging-related signal transduction, leading to skin photoaging. Dihydrocaffeic acid (DHCA) is a phenolic compound with potential antioxidant capacity and is thus a promising compound for the prevention of UVB-induced skin photodamage. The aim of this study was to evaluate the antioxidant and protective effect of DHCA against oxidative stress, apoptosis, and matrix metalloproteinase (MMP) expression via the mitogen-activated protein kinase (MAPK) signaling pathway on L929 fibroblasts irradiated with UVB. DHCA exhibited high antioxidant capacity on 2,2-diphenyl-1-picrylhydrazyl (DPPH•), 2,2-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS•+), and xanthine/luminol/xanthine oxidase (XOD) assays and reduced UVB-induced cell death in the neutral red assay. DHCA also modulated oxidative stress by decreasing intracellular reactive oxygen species (ROS) and extracellular hydrogen peroxide (H2O2) production, enhancing catalase (CAT) and superoxide dismutase (SOD) activities and reduced glutathione (GSH) levels. Hence, cellular damage was attenuated by DHCA, including lipid peroxidation, apoptosis/necrosis and its markers (loss of mitochondria membrane potential, DNA condensation, and cleaved caspase 9 expression), and MMP-1 expression. Furthermore, DHCA reduced the phosphorylation of MAPK p38. These findings suggest that DHCA can be used in the development of skin care products to prevent UVB-induced skin damage.
Chronic UVB exposure promotes oxidative stress, directly causes molecular damage, and induces aging-related signal transduction, leading to skin photoaging. Dihydrocaffeic acid (DHCA) is a phenolic compound with potential antioxidant capacity and is thus a promising compound for the prevention of UVB-induced skin photodamage. The aim of this study was to evaluate the antioxidant and protective effect of DHCA against oxidative stress, apoptosis, and matrix metalloproteinase (MMP) expression via the mitogen-activated protein kinase (MAPK) signaling pathway on L929 fibroblasts irradiated with UVB. DHCA exhibited high antioxidant capacity on 2,2-diphenyl-1-picrylhydrazyl (DPPH ), 2,2-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS ), and xanthine/luminol/xanthine oxidase (XOD) assays and reduced UVB-induced cell death in the neutral red assay. DHCA also modulated oxidative stress by decreasing intracellular reactive oxygen species (ROS) and extracellular hydrogen peroxide (H O ) production, enhancing catalase (CAT) and superoxide dismutase (SOD) activities and reduced glutathione (GSH) levels. Hence, cellular damage was attenuated by DHCA, including lipid peroxidation, apoptosis/necrosis and its markers (loss of mitochondria membrane potential, DNA condensation, and cleaved caspase 9 expression), and MMP-1 expression. Furthermore, DHCA reduced the phosphorylation of MAPK p38. These findings suggest that DHCA can be used in the development of skin care products to prevent UVB-induced skin damage.
Author Nakamura, Celso Vataru
Silva, Sueli de Oliveira
Daré, Regina G.
Oliveira, Mariana M.
Truiti, Maria da Conceição Torrado
Auzely, Rachel
Ueda-Nakamura, Tânia
Ratti, Bianca Altrão
AuthorAffiliation 2 Centre de Recherches sur les Macromolécules Végétales, Université Grenoble Alpes, Grenoble 38041, France
1 Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá 87020-900, Brazil
AuthorAffiliation_xml – name: 1 Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá 87020-900, Brazil
– name: 2 Centre de Recherches sur les Macromolécules Végétales, Université Grenoble Alpes, Grenoble 38041, France
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/30800206$$D View this record in MEDLINE/PubMed
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Copyright Copyright © 2019 Mariana M. Oliveira et al.
Copyright © 2019 Mariana M. Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0
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– notice: Copyright © 2019 Mariana M. Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0
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  doi: 10.1080/10942912.2014.983607
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Snippet Chronic UVB exposure promotes oxidative stress, directly causes molecular damage, and induces aging-related signal transduction, leading to skin photoaging....
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SubjectTerms Acids
Animals
Antioxidants - pharmacology
Apoptosis
Apoptosis - drug effects
Apoptosis - radiation effects
Caffeic Acids - chemistry
Caffeic Acids - pharmacology
Cell Line
Cell Survival - drug effects
Cell Survival - radiation effects
Cytoprotection - drug effects
Cytoprotection - radiation effects
Ethanol
Fibroblasts
Kinases
Laboratories
Lipid peroxidation
Lipid Peroxidation - drug effects
Lipid Peroxidation - radiation effects
MAP Kinase Signaling System - drug effects
MAP Kinase Signaling System - radiation effects
Matrix Metalloproteinase 1 - metabolism
Membrane Potential, Mitochondrial - drug effects
Membrane Potential, Mitochondrial - radiation effects
Mice
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - radiation effects
p38 Mitogen-Activated Protein Kinases - metabolism
Phosphorylation - drug effects
Phosphorylation - radiation effects
Polyphenols
Proteins
Reactive oxygen species
Reactive Oxygen Species - metabolism
Signal transduction
Ultraviolet Rays
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Title Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway
URI https://search.emarefa.net/detail/BIM-1202662
https://dx.doi.org/10.1155/2019/2419096
https://www.ncbi.nlm.nih.gov/pubmed/30800206
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https://search.proquest.com/docview/2185874137
https://pubmed.ncbi.nlm.nih.gov/PMC6360051
Volume 2019
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