Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels

• Published in: Metabolism, clinical and experimental Vol. 63; no. 4; pp. 574 - 583
• Main Authors: Tanisawa, Kumpei, Taniguchi, Hirokazu, Sun, Xiaomin, Ito, Tomoko, Cao, Zhen-Bo, Sakamoto, Shizuo, Higuchi, Mitsuru
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.2014; Elsevier
• Subjects: Adult; Aged; Biological and medical sciences; Blood Glucose - metabolism; Cardiorespiratory fitness; Cross-Sectional Studies; Endocrinology & Metabolism; Feeding. Feeding behavior; Fibronectins - blood; Fibronectins - genetics; FNDC5; Fundamental and applied biological sciences. Psychology; Glucose metabolism; Humans; Irisin; Japan; Male; Middle Aged; Physical Fitness; Polymorphism, Single Nucleotide; SNP; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Young Adult; Japan; VO2peak; LDL-C; FFM; WC; HDL-C; FNDC5; Irisin; Glucose metabolism; TG; SNP; Cardiorespiratory fitness; FPG; MVPA; BMI; triglyceride; free fat mass; waist circumference; body mass index; VO 2peak; HDL cholesterol; peak oxygen uptake; fasting plasma glucose; LDL cholesterol; moderate- and vigorous-intensity physical activity; Human; Association; Gene; Serum; Glucose; Single nucleotide polymorphism; Metabolism; Japanese; Endocrinology; Fitness

This cross-sectional study analyzed the association of serum irisin concentrations with cardiorespiratory fitness levels and common single nucleotide polymorphisms (SNPs) in the FNDC5 gene and examined the relationships between cardiorespiratory fitness levels, common SNPs in FNDC5, and glucose meta...