Combined nitric oxide-releasing poly(vinyl alcohol) film/F127 hydrogel for accelerating wound healing

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 130; pp. 182 - 191
• Main Authors: Schanuel, Fernanda Seabra, Raggio Santos, Karen Slis, Monte-Alto-Costa, Andréa, de Oliveira, Marcelo G.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2015
• Subjects: Actins - metabolism; Alcohols; animal models; Animals; Antigens, Differentiation - metabolism; biocompatible materials; Biomaterials; Blotting, Western; collagen; crosslinking; Density; Esterification; ethylene oxide; F127 hydrogel; hydrocolloids; Hydrogels; Hydrogels - chemistry; Hydrogels - metabolism; Hydrogels - pharmacology; Immunohistochemistry; Male; Mice; Nitric oxide; Nitric Oxide - chemistry; Nitric Oxide - metabolism; Pluronic F127; Poloxamer - chemistry; Poloxamer - metabolism; Poly(vinyl alcohol); polyethylene glycol; Polyethylene Glycols - chemistry; Polyethylene Glycols - metabolism; polyvinyl alcohol; Polyvinyl Alcohol - chemistry; Polyvinyl Alcohol - metabolism; Polyvinyl Alcohol - pharmacology; Propylene Glycols - chemistry; Propylene Glycols - metabolism; propylene oxide; Releasing; S-nitrosoglutathione; S-Nitrosoglutathione - chemistry; S-Nitrosoglutathione - metabolism; Skin - metabolism; Skin - pathology; Skin - physiopathology; skin lesions; Sulfhydryl Compounds - chemistry; swelling (materials); Thiomalates - chemistry; Time Factors; tissue repair; vasodilation; Wound dressing; Wound healing; Wound Healing - drug effects; F127 hydrogel; Poly(vinyl alcohol); Wound dressing; Wound healing; S-nitrosoglutathione; Nitric oxide

•PVA films functionalized with nitric oxide releasing SNO groups were prepared.•PVA-SNO films were combined with a layer of micellar Pluronic F127 hydrogel.•Combined PVA-SNO films/F127 hydrogel reduced the rate of NO delivery to tissues.•Topical application of PVA-SNO films/F127 hydrogel improved wo...