Roles of Wnt8a during formation and patterning of the mouse inner ear

• Published in: Mechanisms of development Vol. 130; no. 2-3; pp. 160 - 168
• Main Authors: Vendrell, Victor, Vázquez-Echeverría, Citlali, López-Hernández, Iris, Alonso, Beatriz Durán, Martinez, Salvador, Pujades, Cristina, Schimmang, Thomas
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.02.2013; Elsevier
• Subjects: Animals; Body Patterning - genetics; Down-Regulation; Ear, Inner - embryology; Ear, Inner - metabolism; Endolymphatic Duct - embryology; Endolymphatic Duct - metabolism; Fgf; Fibroblast Growth Factor 3 - genetics; Fibroblast Growth Factor 3 - metabolism; Fibroblast Growth Factors - genetics; Fibroblast Growth Factors - metabolism; Gene Deletion; Gene Expression; Gene Expression Regulation, Developmental; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - metabolism; Laberint (Orella); Metabolisme; Mice; Mice, Inbred C57BL; Otic placode; Otic specification; Proteïnes; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; Rhombencephalon - embryology; Rhombencephalon - metabolism; Wnt; Wnt Proteins - genetics; Wnt Proteins - metabolism; Wnt Signaling Pathway; Wnt1 Protein - genetics; Otic placode; Fgf; Wnt; Otic specification

► Loss of Fgf3 leads to absence of Wnt8a expression during murine inner ear formation. ► Wnt8a mouse mutants show no defects during inner ear development. ► Double mutants for Wnt8a and Fgf3 show reduced expression of Fgf15. ► Double mutants for Wnt1 and Wnt8a show defects during dorsal morphogenesi...