Physico-Chemical Properties, Aerosolization and Dissolution of Co-Spray Dried Azithromycin Particles with L-Leucine for Inhalation

• Published in: Pharmaceutical research Vol. 35; no. 2; pp. 28 - 15
• Main Authors: Mangal, Sharad, Nie, Haichen, Xu, Rongkun, Guo, Rui, Cavallaro, Alex, Zemlyanov, Dmitry, Zhou, Qi (Tony)
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2018; Springer; Springer Nature B.V
• Subjects: Administration, Inhalation; Amino acids; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Antibiotics; Azithromycin; Azithromycin - administration & dosage; Azithromycin - pharmacokinetics; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Chemical properties; Dissolution; Drug Carriers - chemistry; Drug Compounding - methods; Drug Liberation; Dry Powder Inhalers; Drying; Formulation and Manufacturing of Solid Dosage Forms; Health aspects; Humans; Infection; Inhalation; Inhalers; Leucine; Leucine - chemistry; Medical Law; Morphology; Particle Size; Pharmacology/Toxicology; Pharmacy; Physicochemical properties; Powder; Research Paper; Respiratory tract diseases; Respiratory Tract Infections - drug therapy; Solubility; aerosol performance; dissolution; L-leucine; poorly water soluble drug; solubility; azithromycin; dry powder inhaler; spray drying

Purpose Inhalation therapy is popular to treat lower respiratory tract infections. Azithromycin is effective against some bacteria that cause respiratory tract infections; but it has poor water solubility that may limit its efficacy when administrated as inhalation therapy. In this study, dry powder...