GABRB2 Association with Schizophrenia: Commonalities and Differences Between Ethnic Groups and Clinical Subtypes

• Published in: Biological psychiatry (1969) Vol. 61; no. 5; pp. 653 - 660
• Main Authors: Lo, Wing-Sze, Harano, Mutsuo, Gawlik, Micha, Yu, Zhiliang, Chen, Jianhuan, Pun, Frank W., Tong, Ka-Lok, Zhao, Cunyou, Ng, Siu-Kin, Tsang, Shui-Ying, Uchimura, Naohisa, Stober, Gerald, Xue, Hong
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2007; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Biological and medical sciences; Case-Control Studies; Complex disease; Ethnic Groups; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Germany - ethnology; haplotype; Humans; Introns; Japan - ethnology; Linkage Disequilibrium; Male; Medical sciences; Middle Aged; Polymorphism, Single Nucleotide; population association; psychiatric disorder; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Receptors, GABA-A - genetics; Schizophrenia; Schizophrenia - classification; Schizophrenia - genetics; SNP; Japan; Germany; psychiatric disorder; population association; haplotype; Complex disease; SNP; Psychosis; Schizophrenia; Mental disorder; Genetics; Genetic determinism; Haplotype; Ethnic group

Single nucleotide polymorphisms (SNPs) and haplotypes in intron 8 of type A γ-aminobutyric acid (GABA A) receptor β 2 subunit gene (GABRB2) were initially found to be associated with schizophrenia in Chinese. This finding was subjected to cross-validation in this study with Japanese (JP) and German...