Telomeric repeat-containing RNA is dysregulated in acute myeloid leukemia

• Published in: Blood advances Vol. 7; no. 22; pp. 7067 - 7078
• Main Authors: Catto, Luiz Fernando B., Zanelatto, Leonardo C., Donaires, Flavia S., de Carvalho, Vinicius S., Santana, Bárbara A., Pinto, André L., Fantacini, Daianne, de Souza, Lucas Eduardo B., Fonseca, Natasha P., Telho, Bruno S., Ayrosa Madeira, Maria Isabel, Barbosa Pagnano, Katia Borgia, Firmato, Ana Beatriz, Fagundes, Evandro Maranhão, Higashi, Marcia, Nunes, Elenaide Coutinho, Traina, Fabiola, Lobo de F. Pontes, Lorena, Rego, Eduardo M., Calado, Rodrigo T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.11.2023; The American Society of Hematology
• Subjects: Cell Line; DNA; Humans; Leukemia, Myeloid, Acute - genetics; Myeloid Neoplasia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA, Long Noncoding; Telomerase

•TERRA is repressed in primary human hematopoietic cells (in the bone marrow and peripheral blood), regardless of their telomere lengths.•TERRA is dysregulated in a subset of AML characterized by higher R-loop formation and low TERT and RNAseH2 expression. [Display omitted] TERRA (telomeric repeat-c...