The neuroinflammatory component of negative affect in patients with chronic pain

• Published in: Molecular psychiatry Vol. 26; no. 3; pp. 864 - 874
• Main Authors: Albrecht, D. S., Kim, M., Akeju, O., Torrado-Carvajal, A., Edwards, R. R., Zhang, Y., Bergan, C., Protsenko, E., Kucyi, A., Wasan, A. D., Hooker, J. M., Napadow, V., Loggia, M. L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2021; Nature Publishing Group
• Subjects: 59/36; 59/57; 59/78; 631/378; 692/699/476/1414; Adult; Affect (Psychology); Behavioral Sciences; Biological Psychology; Brain - diagnostic imaging; Brain diseases; Chronic pain; Chronic Pain - diagnostic imaging; Comorbidity; Development and progression; Emotions; Health aspects; Humans; Inflammation; Low back pain; Magnetic Resonance Imaging; Medicine; Medicine & Public Health; Middle Aged; Neural networks; Neuroglia; Neuroimaging; Neuronal-glial interactions; Neurosciences; Pain; Pharmacotherapy; Positron emission tomography; Psychiatry; Psychological aspects; Receptors, GABA; United States

Negative affect (NA) is a significant cause of disability for chronic pain patients. While little is known about the mechanism underlying pain-comorbid NA, previous studies have implicated neuroinflammation in the pathophysiology of both depression and chronic pain. Here, we tested the hypothesis th...