Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence - Slivicki, Richard A.; Xu, Zhili; Kulkarni, Pushkar M.; Pertwee, Roger G.; Mackie, Ken; Thakur, Ganesh A.; Hohmann, Andrea G. (Biological psychiatry (1969), 2018)
Keywords: Allosteric modulator; Animals; Benzamides - pharmacology; Benzodioxoles - pharmacology; Benzoxazines - pharmacology; Cannabinoid Receptor Agonists - pharmacology; Carbamates - pharmacology; Cell Line, Tumor; Disease Models, Animal; Endocannabinoid; Humans; Hyperalgesia - chemically induced; Hyperalgesia - drug therapy; Indoles - pharmacology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines - pharmacology; Naphthalenes - pharmacology; Neuralgia - etiology; Neuropathic pain; Paclitaxel; Physical dependence; Piperidines - pharmacology; Receptor, Cannabinoid, CB1 - agonists; Receptor, Cannabinoid, CB1 - antagonists & inhibitors; Receptor, Cannabinoid, CB1 - metabolism; Reward; Withdrawal; Physical dependence; Allosteric modulator; Reward; Endocannabinoid; Withdrawal; Neuropathic pain