Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II

Background Many SNPs have been identified in genes regulating LDL-C metabolism, but whether their influence is similar in subjects from different ethnicities is unclear. Effect of 4 such SNPs on LDL-C and coronary heart disease (CHD) was examined in Pakistani subjects and was compared with middle ag...

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Published inLipids in health and disease Vol. 15; no. 1; p. 83
Main Authors Shahid, Saleem Ullah, ᅟ, Shabana, Cooper, Jackie A., Beaney, Katherine E., Li, Kawah, Rehman, Abdul, Humphries, Stephen Eric
Format Journal Article
LanguageEnglish
Published London BioMed Central 26.04.2016
BioMed Central Ltd
Subjects
Adaptor Proteins, Vesicular Transport - genetics
Aged
Apolipoprotein B-100 - genetics
Apolipoproteins E - genetics
Biomedical and Life Sciences
Care and treatment
Cholesterol, LDL - blood
Cholesterol, LDL - genetics
Clinical Nutrition
Cohort Studies
Coronary Artery Disease - genetics
Coronary heart disease
Female
Gene Frequency
Genetic aspects
Humans
Influence
Life Sciences
Lipidology
Low density lipoproteins
Male
Medical Biochemistry
Middle Aged
Pakistan
Polymorphism, Single Nucleotide
Single nucleotide polymorphisms
United Kingdom
Pakistan
Gene score
LDL-C
APOE
APOB
SORT1
Online AccessGet full text
ISSN1476-511X
1476-511X
DOI10.1186/s12944-016-0253-0

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Abstract Background Many SNPs have been identified in genes regulating LDL-C metabolism, but whether their influence is similar in subjects from different ethnicities is unclear. Effect of 4 such SNPs on LDL-C and coronary heart disease (CHD) was examined in Pakistani subjects and was compared with middle aged UK men from Northwick Park Heart Study II (NPHSII). Methods One thousand nine hundred sixty-five (1770 non CHD, 195 CHD) UK and 623 (219 non CHD, 404 CHD) Pakistani subjects were enrolled in the study. The SNPs SORT1 rs646776, APOB rs1042031 and APOE rs429358, rs7412 were genotyped by TaqMan/KASPar technique and their gene score was calculated. LDL-C was calculated by Friedewald equation, results were analyzed using SPSS. Results Allele frequencies were significantly different ( p  = <0.05) between UK and Pakistani subjects. However, the SNPs were associated with LDL-C in both groups. In UK non CHD, UK CHD, Pakistani non CHD and Pakistani CHD respectively, for rs646776, per risk allele increase in LDL-C(mmol/l) was 0.18(0.04), 0.06(0.11), 0.15(0.04) and 0.27(0.06) respectively. For rs1042031, per risk allele increase in LDL-C in four groups was 0.11(0.04), 0.04(0.14), 0.15(0.06) and 0.25(0.09) respectively. For APOE genotypes, compared to Ɛ3, each Ɛ2 decreased LDL-C by 0.11(0.06), 0.07(0.15), 0.20(0.08) and 0.38(0.09), while each Ɛ4 increased LDL-C by 0.43(0.06), 0.39(0.21), 0.19(0.11) and 0.39(0.14) respectively. Overall gene score explained a considerable proportion of sample variance in four groups (3.8 %, 1.26 % 13.7 % and 12.3 %). Gene score in both non-CHD groups was significantly lower than CHD subjects. Conclusions The SNPs show a dose response association with LDL-C levels and risk of CHD in both populations.
AbstractList Many SNPs have been identified in genes regulating LDL-C metabolism, but whether their influence is similar in subjects from different ethnicities is unclear. Effect of 4 such SNPs on LDL-C and coronary heart disease (CHD) was examined in Pakistani subjects and was compared with middle aged UK men from Northwick Park Heart Study II (NPHSII).BACKGROUNDMany SNPs have been identified in genes regulating LDL-C metabolism, but whether their influence is similar in subjects from different ethnicities is unclear. Effect of 4 such SNPs on LDL-C and coronary heart disease (CHD) was examined in Pakistani subjects and was compared with middle aged UK men from Northwick Park Heart Study II (NPHSII).One thousand nine hundred sixty-five (1770 non CHD, 195 CHD) UK and 623 (219 non CHD, 404 CHD) Pakistani subjects were enrolled in the study. The SNPs SORT1 rs646776, APOB rs1042031 and APOE rs429358, rs7412 were genotyped by TaqMan/KASPar technique and their gene score was calculated. LDL-C was calculated by Friedewald equation, results were analyzed using SPSS.METHODSOne thousand nine hundred sixty-five (1770 non CHD, 195 CHD) UK and 623 (219 non CHD, 404 CHD) Pakistani subjects were enrolled in the study. The SNPs SORT1 rs646776, APOB rs1042031 and APOE rs429358, rs7412 were genotyped by TaqMan/KASPar technique and their gene score was calculated. LDL-C was calculated by Friedewald equation, results were analyzed using SPSS.Allele frequencies were significantly different (p= <0.05) between UK and Pakistani subjects. However, the SNPs were associated with LDL-C in both groups. In UK non CHD, UK CHD, Pakistani non CHD and Pakistani CHD respectively, for rs646776, per risk allele increase in LDL-C(mmol/l) was 0.18(0.04), 0.06(0.11), 0.15(0.04) and 0.27(0.06) respectively. For rs1042031, per risk allele increase in LDL-C in four groups was 0.11(0.04), 0.04(0.14), 0.15(0.06) and 0.25(0.09) respectively. For APOE genotypes, compared to Ɛ3, each Ɛ2 decreased LDL-C by 0.11(0.06), 0.07(0.15), 0.20(0.08) and 0.38(0.09), while each Ɛ4 increased LDL-C by 0.43(0.06), 0.39(0.21), 0.19(0.11) and 0.39(0.14) respectively. Overall gene score explained a considerable proportion of sample variance in four groups (3.8%, 1.26% 13.7% and 12.3%). Gene score in both non-CHD groups was significantly lower than CHD subjects.RESULTSAllele frequencies were significantly different (p= <0.05) between UK and Pakistani subjects. However, the SNPs were associated with LDL-C in both groups. In UK non CHD, UK CHD, Pakistani non CHD and Pakistani CHD respectively, for rs646776, per risk allele increase in LDL-C(mmol/l) was 0.18(0.04), 0.06(0.11), 0.15(0.04) and 0.27(0.06) respectively. For rs1042031, per risk allele increase in LDL-C in four groups was 0.11(0.04), 0.04(0.14), 0.15(0.06) and 0.25(0.09) respectively. For APOE genotypes, compared to Ɛ3, each Ɛ2 decreased LDL-C by 0.11(0.06), 0.07(0.15), 0.20(0.08) and 0.38(0.09), while each Ɛ4 increased LDL-C by 0.43(0.06), 0.39(0.21), 0.19(0.11) and 0.39(0.14) respectively. Overall gene score explained a considerable proportion of sample variance in four groups (3.8%, 1.26% 13.7% and 12.3%). Gene score in both non-CHD groups was significantly lower than CHD subjects.The SNPs show a dose response association with LDL-C levels and risk of CHD in both populations.CONCLUSIONSThe SNPs show a dose response association with LDL-C levels and risk of CHD in both populations.
Many SNPs have been identified in genes regulating LDL-C metabolism, but whether their influence is similar in subjects from different ethnicities is unclear. Effect of 4 such SNPs on LDL-C and coronary heart disease (CHD) was examined in Pakistani subjects and was compared with middle aged UK men from Northwick Park Heart Study II (NPHSII). One thousand nine hundred sixty-five (1770 non CHD, 195 CHD) UK and 623 (219 non CHD, 404 CHD) Pakistani subjects were enrolled in the study. The SNPs SORT1 rs646776, APOB rs1042031 and APOE rs429358, rs7412 were genotyped by TaqMan/KASPar technique and their gene score was calculated. LDL-C was calculated by Friedewald equation, results were analyzed using SPSS. Allele frequencies were significantly different (p= <0.05) between UK and Pakistani subjects. However, the SNPs were associated with LDL-C in both groups. In UK non CHD, UK CHD, Pakistani non CHD and Pakistani CHD respectively, for rs646776, per risk allele increase in LDL-C(mmol/l) was 0.18(0.04), 0.06(0.11), 0.15(0.04) and 0.27(0.06) respectively. For rs1042031, per risk allele increase in LDL-C in four groups was 0.11(0.04), 0.04(0.14), 0.15(0.06) and 0.25(0.09) respectively. For APOE genotypes, compared to Ɛ3, each Ɛ2 decreased LDL-C by 0.11(0.06), 0.07(0.15), 0.20(0.08) and 0.38(0.09), while each Ɛ4 increased LDL-C by 0.43(0.06), 0.39(0.21), 0.19(0.11) and 0.39(0.14) respectively. Overall gene score explained a considerable proportion of sample variance in four groups (3.8%, 1.26% 13.7% and 12.3%). Gene score in both non-CHD groups was significantly lower than CHD subjects. The SNPs show a dose response association with LDL-C levels and risk of CHD in both populations.
Background Many SNPs have been identified in genes regulating LDL-C metabolism, but whether their influence is similar in subjects from different ethnicities is unclear. Effect of 4 such SNPs on LDL-C and coronary heart disease (CHD) was examined in Pakistani subjects and was compared with middle aged UK men from Northwick Park Heart Study II (NPHSII). Methods One thousand nine hundred sixty-five (1770 non CHD, 195 CHD) UK and 623 (219 non CHD, 404 CHD) Pakistani subjects were enrolled in the study. The SNPs SORT1 rs646776, APOB rs1042031 and APOE rs429358, rs7412 were genotyped by TaqMan/KASPar technique and their gene score was calculated. LDL-C was calculated by Friedewald equation, results were analyzed using SPSS. Results Allele frequencies were significantly different ( p  = <0.05) between UK and Pakistani subjects. However, the SNPs were associated with LDL-C in both groups. In UK non CHD, UK CHD, Pakistani non CHD and Pakistani CHD respectively, for rs646776, per risk allele increase in LDL-C(mmol/l) was 0.18(0.04), 0.06(0.11), 0.15(0.04) and 0.27(0.06) respectively. For rs1042031, per risk allele increase in LDL-C in four groups was 0.11(0.04), 0.04(0.14), 0.15(0.06) and 0.25(0.09) respectively. For APOE genotypes, compared to Ɛ3, each Ɛ2 decreased LDL-C by 0.11(0.06), 0.07(0.15), 0.20(0.08) and 0.38(0.09), while each Ɛ4 increased LDL-C by 0.43(0.06), 0.39(0.21), 0.19(0.11) and 0.39(0.14) respectively. Overall gene score explained a considerable proportion of sample variance in four groups (3.8 %, 1.26 % 13.7 % and 12.3 %). Gene score in both non-CHD groups was significantly lower than CHD subjects. Conclusions The SNPs show a dose response association with LDL-C levels and risk of CHD in both populations.
Background Many SNPs have been identified in genes regulating LDL-C metabolism, but whether their influence is similar in subjects from different ethnicities is unclear. Effect of 4 such SNPs on LDL-C and coronary heart disease (CHD) was examined in Pakistani subjects and was compared with middle aged UK men from Northwick Park Heart Study II (NPHSII). Methods One thousand nine hundred sixty-five (1770 non CHD, 195 CHD) UK and 623 (219 non CHD, 404 CHD) Pakistani subjects were enrolled in the study. The SNPs SORT1 rs646776, APOB rs1042031 and APOE rs429358, rs7412 were genotyped by TaqMan/KASPar technique and their gene score was calculated. LDL-C was calculated by Friedewald equation, results were analyzed using SPSS. Results Allele frequencies were significantly different (p = <0.05) between UK and Pakistani subjects. However, the SNPs were associated with LDL-C in both groups. In UK non CHD, UK CHD, Pakistani non CHD and Pakistani CHD respectively, for rs646776, per risk allele increase in LDL-C(mmol/l) was 0.18(0.04), 0.06(0.11), 0.15(0.04) and 0.27(0.06) respectively. For rs1042031, per risk allele increase in LDL-C in four groups was 0.11(0.04), 0.04(0.14), 0.15(0.06) and 0.25(0.09) respectively. For APOE genotypes, compared to [E]3, each [E]2 decreased LDL-C by 0.11(0.06), 0.07(0.15), 0.20(0.08) and 0.38(0.09), while each [E]4 increased LDL-C by 0.43(0.06), 0.39(0.21), 0.19(0.11) and 0.39(0.14) respectively. Overall gene score explained a considerable proportion of sample variance in four groups (3.8 %, 1.26 % 13.7 % and 12.3 %). Gene score in both non-CHD groups was significantly lower than CHD subjects. Conclusions The SNPs show a dose response association with LDL-C levels and risk of CHD in both populations.
ArticleNumber 83
Audience Academic
Author Humphries, Stephen Eric
Shahid, Saleem Ullah
ᅟ, Shabana
Rehman, Abdul
Cooper, Jackie A.
Beaney, Katherine E.
Li, Kawah
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Cites_doi 10.1016/j.atherosclerosis.2011.03.008
10.1007/s12041-012-0127-9
10.1194/jlr.R800058-JLR200
10.1161/CIRCGENETICS.108.829473
10.1097/MOL.0b013e3283654e7c
10.1007/s00439-003-0988-3
10.1161/CIRCGENETICS.109.914267
10.1016/S0140-6736(12)62127-8
10.1161/CIRCGENETICS.109.906180
10.1159/000218711
10.1161/01.ATV.12.2.256
10.1161/CIRCGENETICS.111.959577
10.1186/1471-2350-11-62
10.1001/jama.298.11.1300
10.1371/journal.pgen.1002138
10.1097/MOL.0b013e32834477a9
10.1038/ng.2797
10.1016/j.atherosclerosis.2009.06.034
10.1038/nature09270
10.1172/JCI63563
10.1038/ng.75
10.1038/sj.ejhg.5201466
10.1038/ng.2795
10.1007/s11033-013-3000-x
10.1046/j.1469-1809.2003.00017.x
10.1371/journal.pone.0046385
10.1016/j.atherosclerosis.2004.12.026
10.1016/j.atherosclerosis.2008.06.007
10.1194/jlr.M800456-JLR200
10.1055/s-0038-1653729
10.2217/clp.10.26
10.1038/ng.939
10.1210/jcem-73-5-925
10.1016/S0021-9150(02)00425-2
10.1371/journal.pone.0130754
10.1016/S0022-2275(20)42621-5
10.1161/ATVBAHA.112.301193
10.1016/j.jjcc.2014.02.012
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Issue 1
Keywords Gene score
LDL-C
APOE
APOB
SORT1
Language English
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References PJ Talmud (253_CR26) 2013; 381
JM Ordovas (253_CR13) 2011; 22
H Li (253_CR38) 2013; 33
J Gallagher (253_CR36) 1992; 12
YJ Kim (253_CR12) 2011; 43
D Burman (253_CR4) 2009; 203
R Lamia (253_CR37) 2012; 91
GS Getz (253_CR39) 2009; 50
TM Teslovich (253_CR25) 2010; 466
BT Heijmans (253_CR6) 2005; 13
S Kathiresan (253_CR32) 2008; 40
A Strong (253_CR30) 2012; 122
SM Boekholdt (253_CR35) 2003; 113
MH Chang (253_CR9) 2010; 11
R Do (253_CR1) 2013; 45
F Takeuchi (253_CR42) 2012; 7
253_CR10
KH Weisgraber (253_CR41) 1990; 31
D Saleheen (253_CR11) 2010; 3
ME Keebler (253_CR18) 2009; 2
R LAMIA (253_CR19) 2012; 91
RA LOBO (253_CR29) 1991; 73
CJ Willer (253_CR8) 2013; 45
A Adeyemo (253_CR14) 2009; 13
L Dumitrescu (253_CR15) 2011; 7
C M-h (253_CR16) 2011; 4
KE Beaney (253_CR27) 2015; 10
R Iqbal (253_CR5) 2014; 41
BH Shirts (253_CR31) 2011; 217
E Hawe (253_CR23) 2003; 67
LM Holdt (253_CR33) 2013; 24
G Miller (253_CR22) 1995; 73
JA Cooper (253_CR24) 2005; 181
T Asia (253_CR3) 2014; 27
MC Carr (253_CR28) 2000; 48
BD Chiodini (253_CR34) 2003; 167
I Rudkowska (253_CR2) 2010; 5
253_CR20
ES Tai (253_CR7) 2009; 50
AM Bennet (253_CR40) 2007; 298
P Linsel-Nitschke (253_CR21) 2010; 208
ME Keebler (253_CR17) 2010; 3
24005217 - Curr Opin Lipidol. 2013 Oct;24(5):410-8
12942366 - Hum Genet. 2003 Oct;113(5):417-25
12675686 - Ann Hum Genet. 2003 Mar;67(Pt 2):97-106
2280190 - J Lipid Res. 1990 Aug;31(8):1503-11
19439916 - Public Health Genomics. 2010;13(2):72-9
18656198 - Atherosclerosis. 2009 Mar;203(1):192-200
19660754 - Atherosclerosis. 2010 Jan;208(1):183-9
22546827 - J Genet. 2012;91(1):75-9
23413428 - Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):687-93
20686565 - Nature. 2010 Aug 5;466(7307):707-13
24097064 - Nat Genet. 2013 Nov;45(11):1345-52
22751103 - J Clin Invest. 2012 Aug;122(8):2807-16
21738485 - PLoS Genet. 2011 Jun;7(6):e1002138
16015283 - Eur J Hum Genet. 2005 Oct;13(10):1143-53
1939531 - J Clin Endocrinol Metab. 1991 Nov;73(5):925-30
24577926 - Pak J Pharm Sci. 2014 Mar;27(2):357-63
20031591 - Circ Cardiovasc Genet. 2009 Jun;2(3):238-43
20570916 - Circ Cardiovasc Genet. 2010 Aug;3(4):358-64
23433573 - Lancet. 2013 Apr 13;381(9874):1293-301
24402875 - Mol Biol Rep. 2014 Mar;41(3):1545-52
1311948 - Arterioscler Thromb. 1992 Feb;12(2):256-60
19018038 - J Lipid Res. 2009 Apr;50 Suppl:S156-61
10916282 - J Investig Med. 2000 Jul;48(4):245-50
17878422 - JAMA. 2007 Sep 19;298(11):1300-11
18987386 - J Lipid Res. 2009 Mar;50(3):514-20
7740501 - Thromb Haemost. 1995 Jan;73(1):82-6
21831959 - Circ Cardiovasc Genet. 2011 Oct;4(5):523-33
24097068 - Nat Genet. 2013 Nov;45(11):1274-83
21909109 - Nat Genet. 2011 Oct;43(10):990-5
21466885 - Atherosclerosis. 2011 Jul;217(1):139-41
21311326 - Curr Opin Lipidol. 2011 Apr;22(2):129-36
23050023 - PLoS One. 2012;7(9):e46385
20406466 - BMC Med Genet. 2010;11:62
24674750 - J Cardiol. 2014 Nov;64(5):339-46
20570915 - Circ Cardiovasc Genet. 2010 Aug;3(4):348-57
12818419 - Atherosclerosis. 2003 Apr;167(2):355-66
18193044 - Nat Genet. 2008 Feb;40(2):189-97
24474739 - Eur Heart J. 2015 Mar 1;36(9):539-50
15939059 - Atherosclerosis. 2005 Jul;181(1):93-100
26133560 - PLoS One. 2015;10(7):e0130754
References_xml – volume: 217
  start-page: 139
  issue: 1
  year: 2011
  ident: 253_CR31
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2011.03.008
– volume: 91
  start-page: 1
  issue: 1
  year: 2012
  ident: 253_CR37
  publication-title: J Genet
  doi: 10.1007/s12041-012-0127-9
– volume: 50
  start-page: S156
  issue: Supplement
  year: 2009
  ident: 253_CR39
  publication-title: J Lipid Res
  doi: 10.1194/jlr.R800058-JLR200
– volume: 2
  start-page: 238
  issue: 3
  year: 2009
  ident: 253_CR18
  publication-title: Circ Cardiovasc Genet
  doi: 10.1161/CIRCGENETICS.108.829473
– volume: 24
  start-page: 410
  issue: 5
  year: 2013
  ident: 253_CR33
  publication-title: Curr Opin Lipidol
  doi: 10.1097/MOL.0b013e3283654e7c
– volume: 48
  start-page: 245
  issue: 4
  year: 2000
  ident: 253_CR28
  publication-title: Journal of investigative medicine: the official publication of the American Federation for Clinical Research
– volume: 113
  start-page: 417
  issue: 5
  year: 2003
  ident: 253_CR35
  publication-title: Hum Genet
  doi: 10.1007/s00439-003-0988-3
– volume: 3
  start-page: 358
  issue: 4
  year: 2010
  ident: 253_CR17
  publication-title: Circ Cardiovasc Genet
  doi: 10.1161/CIRCGENETICS.109.914267
– volume: 381
  start-page: 1293
  issue: 9874
  year: 2013
  ident: 253_CR26
  publication-title: Lancet
  doi: 10.1016/S0140-6736(12)62127-8
– volume: 3
  start-page: 348
  issue: 4
  year: 2010
  ident: 253_CR11
  publication-title: Circ Cardiovasc Genet
  doi: 10.1161/CIRCGENETICS.109.906180
– volume: 13
  start-page: 72
  issue: 2
  year: 2009
  ident: 253_CR14
  publication-title: Public Health Genomics
  doi: 10.1159/000218711
– volume: 12
  start-page: 256
  issue: 2
  year: 1992
  ident: 253_CR36
  publication-title: Arterioscler, Thromb, Vasc Biol
  doi: 10.1161/01.ATV.12.2.256
– volume: 4
  start-page: 523
  issue: 5
  year: 2011
  ident: 253_CR16
  publication-title: Circ Cardiovasc Genet
  doi: 10.1161/CIRCGENETICS.111.959577
– volume: 11
  start-page: 62
  year: 2010
  ident: 253_CR9
  publication-title: BMC Med Genet
  doi: 10.1186/1471-2350-11-62
– volume: 298
  start-page: 1300
  issue: 11
  year: 2007
  ident: 253_CR40
  publication-title: Jama
  doi: 10.1001/jama.298.11.1300
– volume: 7
  start-page: e1002138
  issue: 6
  year: 2011
  ident: 253_CR15
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1002138
– volume: 22
  start-page: 129
  issue: 2
  year: 2011
  ident: 253_CR13
  publication-title: Curr Opin Lipidol
  doi: 10.1097/MOL.0b013e32834477a9
– volume: 45
  start-page: 1274
  issue: 11
  year: 2013
  ident: 253_CR8
  publication-title: Nat Genet
  doi: 10.1038/ng.2797
– volume: 91
  start-page: 75
  issue: 1
  year: 2012
  ident: 253_CR19
  publication-title: J Genet
  doi: 10.1007/s12041-012-0127-9
– volume: 208
  start-page: 183
  issue: 1
  year: 2010
  ident: 253_CR21
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2009.06.034
– volume: 466
  start-page: 707
  issue: 7307
  year: 2010
  ident: 253_CR25
  publication-title: Nature
  doi: 10.1038/nature09270
– ident: 253_CR10
– volume: 122
  start-page: 2807
  issue: 8
  year: 2012
  ident: 253_CR30
  publication-title: J Clin Invest
  doi: 10.1172/JCI63563
– volume: 40
  start-page: 189
  issue: 2
  year: 2008
  ident: 253_CR32
  publication-title: Nat Genet
  doi: 10.1038/ng.75
– volume: 13
  start-page: 1143
  issue: 10
  year: 2005
  ident: 253_CR6
  publication-title: Eur J Hum Genet
  doi: 10.1038/sj.ejhg.5201466
– volume: 27
  start-page: 357363
  issue: 2
  year: 2014
  ident: 253_CR3
  publication-title: Pak J Pharm Sci
– volume: 45
  start-page: 1345
  issue: 11
  year: 2013
  ident: 253_CR1
  publication-title: Nat Genet
  doi: 10.1038/ng.2795
– volume: 41
  start-page: 1545
  issue: 3
  year: 2014
  ident: 253_CR5
  publication-title: Mol Biol Rep
  doi: 10.1007/s11033-013-3000-x
– volume: 67
  start-page: 97
  issue: 2
  year: 2003
  ident: 253_CR23
  publication-title: Ann Hum Genet
  doi: 10.1046/j.1469-1809.2003.00017.x
– volume: 7
  start-page: e46385
  issue: 9
  year: 2012
  ident: 253_CR42
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0046385
– volume: 181
  start-page: 93
  issue: 1
  year: 2005
  ident: 253_CR24
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2004.12.026
– volume: 203
  start-page: 192
  issue: 1
  year: 2009
  ident: 253_CR4
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2008.06.007
– volume: 50
  start-page: 514
  issue: 3
  year: 2009
  ident: 253_CR7
  publication-title: J Lipid Res
  doi: 10.1194/jlr.M800456-JLR200
– volume: 73
  start-page: 82
  issue: 1
  year: 1995
  ident: 253_CR22
  publication-title: Thromb Haemost
  doi: 10.1055/s-0038-1653729
– volume: 5
  start-page: 421
  issue: 3
  year: 2010
  ident: 253_CR2
  publication-title: Clinical Lipidology
  doi: 10.2217/clp.10.26
– volume: 43
  start-page: 990
  issue: 10
  year: 2011
  ident: 253_CR12
  publication-title: Nat Genet
  doi: 10.1038/ng.939
– volume: 73
  start-page: 925
  issue: 5
  year: 1991
  ident: 253_CR29
  publication-title: The Journal of Clinical Endocrinology & Metabolism
  doi: 10.1210/jcem-73-5-925
– volume: 167
  start-page: 355
  issue: 2
  year: 2003
  ident: 253_CR34
  publication-title: Atherosclerosis
  doi: 10.1016/S0021-9150(02)00425-2
– volume: 10
  start-page: e0130754
  issue: 7
  year: 2015
  ident: 253_CR27
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0130754
– volume: 31
  start-page: 1503
  issue: 8
  year: 1990
  ident: 253_CR41
  publication-title: J Lipid Res
  doi: 10.1016/S0022-2275(20)42621-5
– volume: 33
  start-page: 687
  issue: 4
  year: 2013
  ident: 253_CR38
  publication-title: Arterioscler, Thromb, Vasc Biol
  doi: 10.1161/ATVBAHA.112.301193
– ident: 253_CR20
  doi: 10.1016/j.jjcc.2014.02.012
– reference: 20686565 - Nature. 2010 Aug 5;466(7307):707-13
– reference: 24402875 - Mol Biol Rep. 2014 Mar;41(3):1545-52
– reference: 19018038 - J Lipid Res. 2009 Apr;50 Suppl:S156-61
– reference: 24577926 - Pak J Pharm Sci. 2014 Mar;27(2):357-63
– reference: 10916282 - J Investig Med. 2000 Jul;48(4):245-50
– reference: 12942366 - Hum Genet. 2003 Oct;113(5):417-25
– reference: 15939059 - Atherosclerosis. 2005 Jul;181(1):93-100
– reference: 21311326 - Curr Opin Lipidol. 2011 Apr;22(2):129-36
– reference: 24474739 - Eur Heart J. 2015 Mar 1;36(9):539-50
– reference: 12675686 - Ann Hum Genet. 2003 Mar;67(Pt 2):97-106
– reference: 26133560 - PLoS One. 2015;10(7):e0130754
– reference: 18193044 - Nat Genet. 2008 Feb;40(2):189-97
– reference: 24005217 - Curr Opin Lipidol. 2013 Oct;24(5):410-8
– reference: 19660754 - Atherosclerosis. 2010 Jan;208(1):183-9
– reference: 16015283 - Eur J Hum Genet. 2005 Oct;13(10):1143-53
– reference: 20031591 - Circ Cardiovasc Genet. 2009 Jun;2(3):238-43
– reference: 21466885 - Atherosclerosis. 2011 Jul;217(1):139-41
– reference: 23433573 - Lancet. 2013 Apr 13;381(9874):1293-301
– reference: 24097064 - Nat Genet. 2013 Nov;45(11):1345-52
– reference: 21738485 - PLoS Genet. 2011 Jun;7(6):e1002138
– reference: 2280190 - J Lipid Res. 1990 Aug;31(8):1503-11
– reference: 21831959 - Circ Cardiovasc Genet. 2011 Oct;4(5):523-33
– reference: 1939531 - J Clin Endocrinol Metab. 1991 Nov;73(5):925-30
– reference: 7740501 - Thromb Haemost. 1995 Jan;73(1):82-6
– reference: 23050023 - PLoS One. 2012;7(9):e46385
– reference: 24674750 - J Cardiol. 2014 Nov;64(5):339-46
– reference: 19439916 - Public Health Genomics. 2010;13(2):72-9
– reference: 18656198 - Atherosclerosis. 2009 Mar;203(1):192-200
– reference: 17878422 - JAMA. 2007 Sep 19;298(11):1300-11
– reference: 20570915 - Circ Cardiovasc Genet. 2010 Aug;3(4):348-57
– reference: 24097068 - Nat Genet. 2013 Nov;45(11):1274-83
– reference: 1311948 - Arterioscler Thromb. 1992 Feb;12(2):256-60
– reference: 22546827 - J Genet. 2012;91(1):75-9
– reference: 20406466 - BMC Med Genet. 2010;11:62
– reference: 21909109 - Nat Genet. 2011 Oct;43(10):990-5
– reference: 23413428 - Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):687-93
– reference: 18987386 - J Lipid Res. 2009 Mar;50(3):514-20
– reference: 20570916 - Circ Cardiovasc Genet. 2010 Aug;3(4):358-64
– reference: 12818419 - Atherosclerosis. 2003 Apr;167(2):355-66
– reference: 22751103 - J Clin Invest. 2012 Aug;122(8):2807-16
SSID ssj0020766
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Snippet Background Many SNPs have been identified in genes regulating LDL-C metabolism, but whether their influence is similar in subjects from different ethnicities...
Many SNPs have been identified in genes regulating LDL-C metabolism, but whether their influence is similar in subjects from different ethnicities is unclear....
Background Many SNPs have been identified in genes regulating LDL-C metabolism, but whether their influence is similar in subjects from different ethnicities...
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Publisher
StartPage 83
SubjectTerms Adaptor Proteins, Vesicular Transport - genetics
Aged
Apolipoprotein B-100 - genetics
Apolipoproteins E - genetics
Biomedical and Life Sciences
Care and treatment
Cholesterol, LDL - blood
Cholesterol, LDL - genetics
Clinical Nutrition
Cohort Studies
Coronary Artery Disease - genetics
Coronary heart disease
Female
Gene Frequency
Genetic aspects
Humans
Influence
Life Sciences
Lipidology
Low density lipoproteins
Male
Medical Biochemistry
Middle Aged
Pakistan
Polymorphism, Single Nucleotide
Single nucleotide polymorphisms
United Kingdom
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Title Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II
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Volume 15
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