Quantitative multi-omics analysis of the effects of mitochondrial dysfunction on lipid metabolism in Saccharomyces cerevisiae

• Published in: Applied microbiology and biotechnology Vol. 104; no. 3; pp. 1211 - 1226
• Main Authors: Guo, Xiaopeng, Zhang, Miaomiao, Gao, Yue, Cao, Guozhen, Lu, Dong, Li, Wenjian
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2020; Springer; Springer Nature B.V
• Subjects: Analysis; biochemical pathways; Biomedical and Life Sciences; Biotechnology; Deficient mutant; Encyclopedias; energy; Energy storage; Fungi; Gene expression; gene expression regulation; Genes; Genetic aspects; Genomes; Genomic analysis; Genomics; Life Sciences; Lipid metabolism; Lipids; Metabolic pathways; Metabolism; Metabolites; metabolomics; Microbial Genetics and Genomics; Microbiology; Mitochondria; mitochondrial genome; multiomics; mutants; Mutation; nuclear genome; Phospholipids; plasma membrane; Proteomics; Saccharomyces cerevisiae; Species; transcriptome; Transcriptomes; Transcriptomics; Yeast; Alabama; China; Respiration-deficient mutant; Mitochondria; Lipid metabolism; Multi-omics analysis; Saccharomyces cerevisiae

In this study, combined genome, transcriptome, and metabolome analysis was performed for eight Saccharomyces cerevisiae mitochondrial respiration-deficient mutants. Each mutant exhibited a unique nuclear genome mutation pattern; the nuclear genome mutations, and thus potentially affected genes and m...