Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns

• Published in: Blood Vol. 120; no. 20; pp. 4191 - 4196
• Main Authors: Schuh, Anna, Becq, Jennifer, Humphray, Sean, Alexa, Adrian, Burns, Adam, Clifford, Ruth, Feller, Stephan M., Grocock, Russell, Henderson, Shirley, Khrebtukova, Irina, Kingsbury, Zoya, Luo, Shujun, McBride, David, Murray, Lisa, Menju, Toshi, Timbs, Adele, Ross, Mark, Taylor, Jenny, Bentley, David
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 15.11.2012; Americain Society of Hematology
• Subjects: Alleles; Biological and medical sciences; Cell Transformation, Neoplastic - genetics; Clonal Deletion; Clone Cells; Disease Progression; DNA Mutational Analysis; DNA, Neoplasm - genetics; Evolution, Molecular; Gene Frequency; Genome-Wide Association Study; Hematologic and hematopoietic diseases; Humans; Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; Leukemia, Lymphocytic, Chronic, B-Cell - physiopathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Mutation; Neoplasm Proteins - genetics; Selection, Genetic; Sequence Analysis, DNA; Clonality; Chronic lymphocytic leukemia; Hematology; Surveillance; Lymphoproliferative syndrome; Malignant hemopathy; Genome; Sequencing; Cancer

Chronic lymphocytic leukemia is characterized by relapse after treatment and chemotherapy resistance. Similarly, in other malignancies leukemia cells accumulate mutations during growth, forming heterogeneous cell populations that are subject to Darwinian selection and may respond differentially to t...