The role of serotonin in personality inference: tryptophan depletion impairs the identification of neuroticism in the face

• Published in: Psychopharmacology Vol. 234; no. 14; pp. 2139 - 2147
• Main Authors: Ward, Robert, Sreenivas, Shubha, Read, Judi, Saunders, Kate E. A., Rogers, Robert D.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2017; Springer; Springer Nature B.V
• Subjects: Adults; Aggression; Aggressive behavior; Amino acids; Anxiety; Anxiety Disorders - psychology; Aversion learning; Biomedical and Life Sciences; Biomedicine; Depletion; Emotions; Face; Facial Expression; Health aspects; Humans; Impulsive Behavior; Inference; Neurosciences; Neurosis; Neuroticism - physiology; Nonverbal communication; Original Investigation; Personality; Personality (Psychology); Personality Disorders - psychology; Personality traits; Pharmacology/Toxicology; Psychiatry; Serial learning; Serotonin; Serotonin - metabolism; System reliability; Tryptophan; Tryptophan - deficiency; Neuroticism; Personality; Serotonin; Psychological distress
• ISSN: 0033-3158; 1432-2072
• DOI: 10.1007/s00213-017-4619-4

Serotonergic mechanisms mediate the expression of personality traits (such as impulsivity, aggression and anxiety) that are linked to vulnerability to psychological illnesses, and modulate the identification of emotional expressions in the face as well as learning about broader classes of appetitive and aversive signals. Faces with neutral expressions signal a variety of socially relevant information, such that inferences about the big five personality traits, including Neuroticism, Extraversion and Agreeableness, can be accurately made on the basis of emotionally neutral facial photographs. Given the close link between Neuroticism and psychological distress, we investigated the effects of diminished central serotonin activity (achieved by tryptophan depletion) upon the accuracy of 52 healthy (non-clinical) adults’ discriminations of personality from facial characteristics. All participants were able to discriminate reliably four of the big five traits. However, the tryptophan-depleted participants were specifically less accurate in discriminating Neuroticism than the matched non-depleted participants. These data suggest that central serotonin activity modulates the identification of not only negative facial emotional expression but also a broader class of signals about personality characteristics linked to psychological distress.