Comparison of Activity and Safety of DSPAα1 and Its N-Glycosylation Mutants - Peng, Huakang; Wang, Nan; Wang, Mengqi; Yang, Caifeng; Guo, Wenfang; Li, Gangqiang; Huang, Sumei; Wei, Di; Liu, Dehu (Life (Basel, Switzerland), 2023)
Keywords: Amino acids; Bleeding; Cloning; Coagulation; Comparative analysis; Coronaviruses; COVID-19; Development and progression; drug safety; Drug therapy; DSPAα1; E coli; Fibrin; fibrin selectivity; Genetic aspects; Glycan; Glycoproteins; Glycosylation; Health aspects; Immune response; Immunological tolerance; In vivo methods and tests; Mutagenesis; Mutants; Mutation; N-glycosylation sites; Pharmaceuticals; Physiological aspects; Physiological effects; Plasmids; plasminogen activator; Proteins; rat; Safety; Temperature tolerance; Testing; Thromboembolism; Thrombolysis; Thrombolytic drugs; Yeast; China; Beijing China; United States--US; DSPAα1; plasminogen activator; N-glycosylation sites; fibrin selectivity; rat; drug safety