Timing of Wnt Inhibition Modulates Directed Differentiation of Medial Ganglionic Eminence Progenitors from Human Pluripotent Stem Cells

• Published in: Stem cells international Vol. 2018; no. 2018; pp. 1 - 11
• Main Authors: Kellermayer, Timot, Sheng, Anna, Lazar, Evelyn, Lew, Alexandra, Ihnatovych, Ivanna, Szigeti, Kinga
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; Hindawi Limited; Wiley
• Subjects: Basal forebrain; Cells (biology); Differentiation; Disease; Embryos; Forebrain; Head; Inhibition; Interneurons; Mental disorders; Mutation; Neural stem cells; Pluripotency; Progenitor cells; Protocol; Spinal cord; Stem cells; Wnt protein; γ-Aminobutyric acid; United States > US

In vitro differentiation of human pluripotent stem cell into relevant cell types is a desirable model system that has the human biological context, is a renewable source, and is scalable. GABA interneurons and basal forebrain cholinergic neurons, derivates of the medial ganglionic eminence (MGE), ar...