Fluorescent glycoprobes: a sweet addition for improved sensing
The development of small-molecule fluorescent probes for the detection of ions and biomacromolecules and for cellular and in vivo imaging has been a very active research area. Nevertheless, many problems exist for traditional probes including their poor water solubility, toxicity and the inability t...
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| Published in | Chemical communications (Cambridge, England) Vol. 53; no. 1; pp. 82 - 9 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
2017
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| Subjects | |
| Online Access | Get full text |
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| Summary: | The development of small-molecule fluorescent probes for the detection of ions and biomacromolecules and for cellular and
in vivo
imaging has been a very active research area. Nevertheless, many problems exist for traditional probes including their poor water solubility, toxicity and the inability to target specific tissues. Because of the enhanced water solubility, biocompatibility and targeting ability for specific cells, there has been an emerging movement to use carbohydrates as either the backbone or as a warhead to decorate conventional fluorescent probes, producing "glycoprobes" with enhanced properties. This feature article provides an overview of recently developed glycoprobes for ion and protein detection as well as targeted (receptor targeting) cellular imaging and theranostics. Here, we summarise the tactics for preparing small molecular glycoprobes and their supramolecular 2D material composites.
We highlight recent progress from our labs for the development of fluorescent glycoprobes for sensing ions/lectins and targeted detection of intracellular species, including the construction of their 2D material composites for targeted fluorescence imaging and theranostics. |
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| Bibliography: | Tony D. James is a Professor at the University of Bath and Fellow of the Royal Society of Chemistry. He obtained his: BSc 1986 (University of East Anglia), PhD 1991 (University of Victoria), and was a Postdoctoral Research Fellow 1991-1995 (with Seiji. Shinkai in Japan). He was a Royal Society Research Fellow from 1995 to 2000 (University of Birmingham). In 2013 he was recognized for his role in developing networks with Japan by the award of a Daiwa-Adrian Prize and in 2015 he received the Inaugural CASE Prize for establishing and developing networks with China. Guo-Rong Chen received her BS in Organic Chemical Engineering (1975) from ECUST. She conducted her research at the Glycochemistry Lab of University Lyon 1 from 1989-1991; she revisited the lab in years 1996, 1998 and 2002. Then she spent two years at Shanghai Institute of Materia Medica (CAS) as a visiting scholar. She was appointed as professor at ECUST in 2001. Her research interests involve glycochemistry, medicinal chemistry, chemical glycobiology and green fine chemicals. Xiao-Peng He received his BS in Applied Chemistry (2006) and PhD in Pharmaceutical Engineering (2011) from ECUST. He conducted a co-tutored doctoral program at ENS Cachan (France) from July 2008 to February 2009 (advisor Prof. Juan Xie) sponsored by the French Embassy. Then he carried out his postdoctoral research with Prof. Kaixian Chen (SIMM, CAS) at ECUST from 2011 to 2013. He's now an associate professor at the Institute of Fine Chemicals, ECUST, where his research interests span chemical glycobiology to construction of fluorescent and electrochemical probes and materials. Jia Li received his PhD from SIMM in 2000 and was promoted to professor in 2005. He stayed at University of Cambridge (UK, Feb 2003-Aug 2003) and Garvan Institute of Medical Research (Australia, Aug 2004-Feb 2005) as a visiting scholar. From year 2013 he was appointed as a deputy director of SIMM. Li's research interests are centered on the investigation of mechanisms of metabolic disease for identifying key genetic and biochemical events, chemical biology and high-throughput drug screening. He received the China National Fund for Distinguished Young Scientists in 2011. Yi Zang received her PhD in Pharmacology from SIMM (CAS). Following a postdoctoral fellowship at MD Anderson Cancer Center in the US, she returned to SIMM in 2010 as an associate professor. Zang focuses her research on the interactome and identification of novel physiological roles of AMPK, the mechanistic study of cell fate regulation using chemical biology tools, and detection of protein-carbohydrate interactions for disease diagnosis and targeted therapy. Juan Xie received her PhD in chemistry at University Paris V in 1998 under the supervision of Professors M. C. Fournier-Zaluski and B. P. Roques. After post-doctoral study at CNRS in the group of Dr M. Wakselman, she moved to University Paris VI as an associate Professor (1991). In 2004, she was appointed full Professor at Ecole Normale Supérieure de Cachan. Her current research interest is focused on bio- and photo-active molecules. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ISSN: | 1359-7345 1364-548X 1364-548X |
| DOI: | 10.1039/c6cc06875h |