MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis

Our recent findings link the apolipoprotein E4 ( ApoE4 )-specific changes in brain phosphoinositol biphosphate (PIP 2 ) homeostasis to the susceptibility of developing Alzheimer’s Disease (AD). In the present study, we have identified miR-195 as a top micro-RNA candidate involved in the ApoE/PIP 2 p...

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Published inMolecular psychiatry Vol. 26; no. 9; pp. 4687 - 4701
Main Authors Cao, Jiqing, Huang, Min, Guo, Lei, Zhu, Li, Hou, Jianwei, Zhang, Larry, Pero, Adriana, Ng, Sabrina, El Gaamouch, Farida, Elder, Gregory, Sano, Mary, Goate, Alison, TCW, Julia, Haroutunian, Vahram, Zhang, Bin, Cai, Dongming
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.09.2021
Nature Publishing Group
Subjects
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Aging
Alzheimer Disease - genetics
Alzheimer's disease
Amyloid beta-Peptides
Animals
Apolipoprotein E
Apolipoprotein E4
Apolipoprotein E4 - genetics
Apolipoproteins
Behavioral Sciences
Biological Psychology
Brain
Brain stem
Cerebrospinal fluid
Cognition
Cognitive ability
Cognitive Dysfunction - genetics
Development and progression
Genetic aspects
Health aspects
Hippocampus
Homeostasis
Humans
Inhibitory postsynaptic potentials
Lysosomes
Medicine
Medicine & Public Health
Mice
Mice, Transgenic
MicroRNA
MicroRNAs
MicroRNAs - genetics
miRNA
Neurodegenerative diseases
Neurosciences
Pathogenesis
Pharmacotherapy
Phenotypes
Phosphatidylinositol 4,5-diphosphate
Phosphorylation
Physiological aspects
Pluripotency
Psychiatry
Stem cell transplantation
Stem cells
Tau protein
United States
Online AccessGet full text

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Abstract Our recent findings link the apolipoprotein E4 ( ApoE4 )-specific changes in brain phosphoinositol biphosphate (PIP 2 ) homeostasis to the susceptibility of developing Alzheimer’s Disease (AD). In the present study, we have identified miR-195 as a top micro-RNA candidate involved in the ApoE/PIP 2 pathway using miRNA profiles in human ROSMAP datasets and mouse microarray studies. Further validation studies have demonstrated that levels of miR-195 are significantly lower in human brain tissue of ApoE4 +/− patients with clinical diagnosis of mild cognitive impairment (MCI) or early AD when compared to ApoE4 −/− subjects. In addition, brain miR-195 levels are reduced along with disease progression from normal aging to early AD, and cerebrospinal fluid (CSF) miR-195 levels of MCI subjects are positively correlated with cognitive performances as measured by mini-mental status examination (MMSE) and negatively correlated with CSF tau levels, suggesting the involvement of miR-195 in early development of AD with a potential impact on cognition. Similar differences in miR-195 levels are seen in ApoE4 +/+ mouse hippocampal brain tissue and cultured neurons when compared to ApoE3 +/+ counterparts. Over-expressing miR-195 reduces expression levels of its top predicted target synaptojanin 1 ( synj1 ), a brain PIP 2 -degrading enzyme. Furthermore, elevating miR-195 ameliorates cognitive deficits, amyloid plaque burden, and tau hyper-phosphorylation in ApoE4 +/+ mice. In addition, elevating miR-195 rescues AD-related lysosomal defects in inducible pluripotent stem cells (iPSCs)-derived brain cells of ApoE4 +/+ AD subjects while inhibiting miR-195 exacerbates these phenotypes. Together, our data uncover a novel regulatory mechanism of miR-195 targeted at ApoE4 -associated brain PIP 2 dyshomeostasis, cognitive deficits, and AD pathology.
AbstractList Our recent findings link the apolipoprotein E4 ( ApoE4 )-specific changes in brain phosphoinositol biphosphate (PIP 2 ) homeostasis to the susceptibility of developing Alzheimer’s Disease (AD). In the present study, we have identified miR-195 as a top micro-RNA candidate involved in the ApoE/PIP 2 pathway using miRNA profiles in human ROSMAP datasets and mouse microarray studies. Further validation studies have demonstrated that levels of miR-195 are significantly lower in human brain tissue of ApoE4 +/− patients with clinical diagnosis of mild cognitive impairment (MCI) or early AD when compared to ApoE4 −/− subjects. In addition, brain miR-195 levels are reduced along with disease progression from normal aging to early AD, and cerebrospinal fluid (CSF) miR-195 levels of MCI subjects are positively correlated with cognitive performances as measured by mini-mental status examination (MMSE) and negatively correlated with CSF tau levels, suggesting the involvement of miR-195 in early development of AD with a potential impact on cognition. Similar differences in miR-195 levels are seen in ApoE4 +/+ mouse hippocampal brain tissue and cultured neurons when compared to ApoE3 +/+ counterparts. Over-expressing miR-195 reduces expression levels of its top predicted target synaptojanin 1 ( synj1 ), a brain PIP 2 -degrading enzyme. Furthermore, elevating miR-195 ameliorates cognitive deficits, amyloid plaque burden, and tau hyper-phosphorylation in ApoE4 +/+ mice. In addition, elevating miR-195 rescues AD-related lysosomal defects in inducible pluripotent stem cells (iPSCs)-derived brain cells of ApoE4 +/+ AD subjects while inhibiting miR-195 exacerbates these phenotypes. Together, our data uncover a novel regulatory mechanism of miR-195 targeted at ApoE4 -associated brain PIP 2 dyshomeostasis, cognitive deficits, and AD pathology.
Our recent findings link the apolipoprotein E4 (ApoE4)-specific changes in brain phosphoinositol biphosphate (PIP.sub.2) homeostasis to the susceptibility of developing Alzheimer's Disease (AD). In the present study, we have identified miR-195 as a top micro-RNA candidate involved in the ApoE/PIP.sub.2 pathway using miRNA profiles in human ROSMAP datasets and mouse microarray studies. Further validation studies have demonstrated that levels of miR-195 are significantly lower in human brain tissue of ApoE4.sup.+/- patients with clinical diagnosis of mild cognitive impairment (MCI) or early AD when compared to ApoE4.sup.-/- subjects. In addition, brain miR-195 levels are reduced along with disease progression from normal aging to early AD, and cerebrospinal fluid (CSF) miR-195 levels of MCI subjects are positively correlated with cognitive performances as measured by mini-mental status examination (MMSE) and negatively correlated with CSF tau levels, suggesting the involvement of miR-195 in early development of AD with a potential impact on cognition. Similar differences in miR-195 levels are seen in ApoE4.sup.+/+ mouse hippocampal brain tissue and cultured neurons when compared to ApoE3.sup.+/+ counterparts. Over-expressing miR-195 reduces expression levels of its top predicted target synaptojanin 1 (synj1), a brain PIP.sub.2-degrading enzyme. Furthermore, elevating miR-195 ameliorates cognitive deficits, amyloid plaque burden, and tau hyper-phosphorylation in ApoE4.sup.+/+ mice. In addition, elevating miR-195 rescues AD-related lysosomal defects in inducible pluripotent stem cells (iPSCs)-derived brain cells of ApoE4.sup.+/+ AD subjects while inhibiting miR-195 exacerbates these phenotypes. Together, our data uncover a novel regulatory mechanism of miR-195 targeted at ApoE4-associated brain PIP.sub.2 dyshomeostasis, cognitive deficits, and AD pathology.
Our recent findings link the apolipoprotein E4 (ApoE4)-specific changes in brain phosphoinositol biphosphate (PIP2) homeostasis to the susceptibility of developing Alzheimer’s Disease (AD). In the present study, we have identified miR-195 as a top micro-RNA candidate involved in the ApoE/PIP2 pathway using miRNA profiles in human ROSMAP datasets and mouse microarray studies. Further validation studies have demonstrated that levels of miR-195 are significantly lower in human brain tissue of ApoE4+/− patients with clinical diagnosis of mild cognitive impairment (MCI) or early AD when compared to ApoE4−/− subjects. In addition, brain miR-195 levels are reduced along with disease progression from normal aging to early AD, and cerebrospinal fluid (CSF) miR-195 levels of MCI subjects are positively correlated with cognitive performances as measured by mini-mental status examination (MMSE) and negatively correlated with CSF tau levels, suggesting the involvement of miR-195 in early development of AD with a potential impact on cognition. Similar differences in miR-195 levels are seen in ApoE4+/+ mouse hippocampal brain tissue and cultured neurons when compared to ApoE3+/+ counterparts. Over-expressing miR-195 reduces expression levels of its top predicted target synaptojanin 1 (synj1), a brain PIP2-degrading enzyme. Furthermore, elevating miR-195 ameliorates cognitive deficits, amyloid plaque burden, and tau hyper-phosphorylation in ApoE4+/+ mice. In addition, elevating miR-195 rescues AD-related lysosomal defects in inducible pluripotent stem cells (iPSCs)-derived brain cells of ApoE4+/+ AD subjects while inhibiting miR-195 exacerbates these phenotypes. Together, our data uncover a novel regulatory mechanism of miR-195 targeted at ApoE4-associated brain PIP2 dyshomeostasis, cognitive deficits, and AD pathology.
Our recent findings link the apolipoprotein E4 (ApoE4)-specific changes in brain phosphoinositol biphosphate (PIP ) homeostasis to the susceptibility of developing Alzheimer's Disease (AD). In the present study, we have identified miR-195 as a top micro-RNA candidate involved in the ApoE/PIP pathway using miRNA profiles in human ROSMAP datasets and mouse microarray studies. Further validation studies have demonstrated that levels of miR-195 are significantly lower in human brain tissue of ApoE4 patients with clinical diagnosis of mild cognitive impairment (MCI) or early AD when compared to ApoE4 subjects. In addition, brain miR-195 levels are reduced along with disease progression from normal aging to early AD, and cerebrospinal fluid (CSF) miR-195 levels of MCI subjects are positively correlated with cognitive performances as measured by mini-mental status examination (MMSE) and negatively correlated with CSF tau levels, suggesting the involvement of miR-195 in early development of AD with a potential impact on cognition. Similar differences in miR-195 levels are seen in ApoE4 mouse hippocampal brain tissue and cultured neurons when compared to ApoE3 counterparts. Over-expressing miR-195 reduces expression levels of its top predicted target synaptojanin 1 (synj1), a brain PIP -degrading enzyme. Furthermore, elevating miR-195 ameliorates cognitive deficits, amyloid plaque burden, and tau hyper-phosphorylation in ApoE4 mice. In addition, elevating miR-195 rescues AD-related lysosomal defects in inducible pluripotent stem cells (iPSCs)-derived brain cells of ApoE4 AD subjects while inhibiting miR-195 exacerbates these phenotypes. Together, our data uncover a novel regulatory mechanism of miR-195 targeted at ApoE4-associated brain PIP dyshomeostasis, cognitive deficits, and AD pathology.
Our recent findings link the apolipoprotein E4 (ApoE4)-specific changes in brain phosphoinositol biphosphate (PIP2) homeostasis to the susceptibility of developing Alzheimer's Disease (AD). In the present study, we have identified miR-195 as a top micro-RNA candidate involved in the ApoE/PIP2 pathway using miRNA profiles in human ROSMAP datasets and mouse microarray studies. Further validation studies have demonstrated that levels of miR-195 are significantly lower in human brain tissue of ApoE4+/- patients with clinical diagnosis of mild cognitive impairment (MCI) or early AD when compared to ApoE4-/- subjects. In addition, brain miR-195 levels are reduced along with disease progression from normal aging to early AD, and cerebrospinal fluid (CSF) miR-195 levels of MCI subjects are positively correlated with cognitive performances as measured by mini-mental status examination (MMSE) and negatively correlated with CSF tau levels, suggesting the involvement of miR-195 in early development of AD with a potential impact on cognition. Similar differences in miR-195 levels are seen in ApoE4+/+ mouse hippocampal brain tissue and cultured neurons when compared to ApoE3+/+ counterparts. Over-expressing miR-195 reduces expression levels of its top predicted target synaptojanin 1 (synj1), a brain PIP2-degrading enzyme. Furthermore, elevating miR-195 ameliorates cognitive deficits, amyloid plaque burden, and tau hyper-phosphorylation in ApoE4+/+ mice. In addition, elevating miR-195 rescues AD-related lysosomal defects in inducible pluripotent stem cells (iPSCs)-derived brain cells of ApoE4+/+ AD subjects while inhibiting miR-195 exacerbates these phenotypes. Together, our data uncover a novel regulatory mechanism of miR-195 targeted at ApoE4-associated brain PIP2 dyshomeostasis, cognitive deficits, and AD pathology.Our recent findings link the apolipoprotein E4 (ApoE4)-specific changes in brain phosphoinositol biphosphate (PIP2) homeostasis to the susceptibility of developing Alzheimer's Disease (AD). In the present study, we have identified miR-195 as a top micro-RNA candidate involved in the ApoE/PIP2 pathway using miRNA profiles in human ROSMAP datasets and mouse microarray studies. Further validation studies have demonstrated that levels of miR-195 are significantly lower in human brain tissue of ApoE4+/- patients with clinical diagnosis of mild cognitive impairment (MCI) or early AD when compared to ApoE4-/- subjects. In addition, brain miR-195 levels are reduced along with disease progression from normal aging to early AD, and cerebrospinal fluid (CSF) miR-195 levels of MCI subjects are positively correlated with cognitive performances as measured by mini-mental status examination (MMSE) and negatively correlated with CSF tau levels, suggesting the involvement of miR-195 in early development of AD with a potential impact on cognition. Similar differences in miR-195 levels are seen in ApoE4+/+ mouse hippocampal brain tissue and cultured neurons when compared to ApoE3+/+ counterparts. Over-expressing miR-195 reduces expression levels of its top predicted target synaptojanin 1 (synj1), a brain PIP2-degrading enzyme. Furthermore, elevating miR-195 ameliorates cognitive deficits, amyloid plaque burden, and tau hyper-phosphorylation in ApoE4+/+ mice. In addition, elevating miR-195 rescues AD-related lysosomal defects in inducible pluripotent stem cells (iPSCs)-derived brain cells of ApoE4+/+ AD subjects while inhibiting miR-195 exacerbates these phenotypes. Together, our data uncover a novel regulatory mechanism of miR-195 targeted at ApoE4-associated brain PIP2 dyshomeostasis, cognitive deficits, and AD pathology.
Audience Academic
Author TCW, Julia
Pero, Adriana
Elder, Gregory
Goate, Alison
Guo, Lei
Cao, Jiqing
Sano, Mary
Hou, Jianwei
El Gaamouch, Farida
Cai, Dongming
Zhu, Li
Ng, Sabrina
Zhang, Bin
Huang, Min
Haroutunian, Vahram
Zhang, Larry
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32632205$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1212/01.WNL.0000128091.92139.0F
10.1126/science.8171342
10.1089/neu.2012.2510
10.1016/0929-7855(96)00545-7
10.1093/nar/gku631
10.1093/bioinformatics/btw002
10.1016/j.celrep.2018.05.011
10.1016/0169-328X(94)00233-5
10.3389/fgene.2019.00153
10.1194/jlr.R076315
10.1007/s10339-011-0430-z
10.1152/ajpcell.00243.2006
10.3233/JAD-2010-100141
10.1523/JNEUROSCI.18-01-00195.1998
10.1186/s13024-016-0069-4
10.1007/978-3-211-09469-3_45
10.1093/bioinformatics/btt656
10.1038/nprot.2010.41
10.1186/s13024-018-0299-8
10.1016/j.bbr.2004.09.019
10.1002/glia.22289
10.1073/pnas.1510011112
10.1038/nn.2100
10.1002/stem.1334
10.1074/jbc.M111.274142
10.1146/annurev-biochem-060308-103103
10.1046/j.1471-4159.1997.68020721.x
10.3233/JAD-141002
10.1038/nm.4386
10.1038/372092a0
10.1073/pnas.0506580102
10.1007/BF00969091
10.1074/jbc.M113.504365
10.1097/WNR.0b013e3280148e8b
10.1016/j.stemcr.2017.06.018
10.1074/jbc.M401055200
10.1523/JNEUROSCI.2034-12.2012
10.1016/j.cell.2017.05.018
10.1523/JNEUROSCI.21-02-00372.2001
10.1016/j.neuron.2016.06.015
10.1016/j.nbd.2014.08.025
10.1523/JNEUROSCI.3872-10.2010
10.1186/s13024-020-0358-9
10.1023/A:1011603916962
10.1093/hmg/dds142
10.1097/00001756-200412030-00020
10.1073/pnas.1504393112
10.1016/j.brainresbull.2012.05.018
10.1046/j.1471-4159.1999.0732613.x
10.1146/annurev.neuro.26.043002.094919
10.1038/nature17664
10.1016/j.neurobiolaging.2005.04.008
10.1016/S0197-0186(01)00050-X
10.3389/fncel.2013.00178
10.1371/journal.pone.0213374
10.1006/abio.2001.5489
10.1101/lm.030031.112
10.1186/gb-2010-11-12-144
10.1038/nrn.2015.1
10.1016/j.neulet.2019.134285
10.2174/156720512801322573
10.1093/nar/gku1104
10.1016/j.brainres.2004.05.029
10.1186/s13024-018-0285-1
10.1007/s11064-004-7036-0
10.1038/nn.4132
10.1016/S0197-4580(98)00105-5
10.1073/pnas.0803756105
10.1159/000087446
10.1016/j.nbd.2004.10.013
10.1006/nbdi.2002.0483
10.1038/nature24016
10.2202/1544-6115.1027
10.1523/JNEUROSCI.2676-05.2006
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References Lukiw (CR37) 2007; 18
Labonte, Engmann, Purushothaman, Menard, Wang, Tan (CR58) 2017; 23
Subramanian, Tamayo, Mootha, Mukherjee, Ebert, Gillette (CR66) 2005; 102
Jordan, Galindo, Miller, Reardon, Getz, LaDu (CR4) 1998; 18
Williams, Borchelt, Chakrabarty (CR76) 2020; 15
Voronov, Frere, Giovedi, Pollina, Borel, Zhang (CR28) 2008; 105
Zhu, Wang, Wang, Song, Tan, Teng (CR67) 2012; 88
Elder, Dorr, De Gasperi, Gama Sosa, Shaughness, Maudlin-Jeronimo (CR60) 2012; 29
Keren-Shaul, Spinrad, Weiner, Matcovitch-Natan, Dvir-Szternfeld, Ulland (CR16) 2017; 169
Chicco, Sparagna (CR69) 2007; 292
Jiang, Sun, Gui, Tang, Zhen, Gu (CR3) 2008; 105
Berman, Dall’Armi, Voronov, McIntire, Zhang, Moore (CR27) 2008; 11
CR30
Passini, Dodge, Bu, Yang, Zhao, Sondhi (CR59) 2006; 26
Antunes, Biala (CR72) 2012; 13
Bennett, Schneider, Arvanitakis, Wilson (CR39) 2012; 9
Wang, Qin, Tang (CR35) 2019; 10
Mandal, McClure, Pettegrew (CR21) 2004; 29
Zhu, Zhong, Elder, Sano, Holtzman, Gandy (CR26) 2015; 112
Love, Siew, Dawbarn, Wilcock, Ben-Shlomo, Allen (CR12) 2006; 27
Oyama, Shimada, Oyama, Ihara (CR8) 1995; 29
Klunk, Panchalingam, McClure, Stanley, Pettegrew (CR25) 1998; 19
Bardy, van den Hurk, Eames, Marchand, Hernandez, Kellogg (CR55) 2015; 112
Huang, Mahley, Apolipoprotein (CR19) 2014; 72
Shaltouki, Peng, Liu, Rao, Zeng (CR57) 2013; 31
Liao, Smyth, Shi (CR64) 2014; 30
Paquet, Kwart, Chen, Sproul, Jacob, Teo (CR56) 2016; 533
Tai, Balu, Avila-Munoz, Abdullah, Thomas, Collins (CR49) 2017; 58
Balu, Karstens, Loukenas, Maldonado Weng, York, Valencia-Olvera (CR48) 2019; 707
CR42
Zhu, Zhong, Zhao, Rhee, Caesar, Knight (CR43) 2013; 288
Bowles, Tcw, Qian, Jadow, Goate (CR53) 2019; 14
CR41
Rodriguez, Burns, Weeber, Rebeck (CR46) 2013; 20
Qiu, Hyman, Rebeck (CR71) 2004; 279
Nasuhoglu, Feng, Mao, Yamamoto, Yin, Earnest (CR51) 2002; 301
Grootendorst, Bour, Vogel, Kelche, Sullivan, Dodart (CR45) 2005; 159
Berg, Nilsson, Thor, Hammarstrom (CR52) 2010; 5
Mayeux (CR1) 2003; 26
Sharman, Morici, Hone, Berger, Taddei, Martins (CR6) 2010; 21
Shi, Yamada, Liddelow, Smith, Zhao, Luo (CR9) 2017; 549
Bennett, Schneider, Buchman, Mendes de Leon, Bienias, Wilson (CR38) 2005; 25
Fabian, Sonenberg, Filipowicz (CR34) 2010; 79
Sierksma, Lu, Salta, Vanden Eynden, Callaerts-Vegh, D’Hooge (CR73) 2018; 13
LaDu, Shah, Reardon, Getz, Bu, Hu (CR70) 2001; 39
Cossec, Lavaur, Berman, Rivals, Hoischen, Stora (CR33) 2012; 21
Asai, Ikezu, Tsunoda, Medalla, Luebke, Haydar (CR74) 2015; 18
Nathan, Bellosta, Sanan, Weisgraber, Mahley, Pitas (CR13) 1994; 264
Tcw, Wang, Pimenova, Bowles, Hartley, Lacin (CR54) 2017; 9
McIntire, Berman, Myaeng, Staniszewski, Arancio, Di Paolo (CR29) 2012; 32
Cao, Gaamouch, Meabon, Meeker, Zhu, Zhong (CR31) 2017; 7
Wong, Wang (CR40) 2015; 43
Monteiro-Cardoso, Oliveira, Melo, Domingues, Moreira, Ferreiro (CR68) 2015; 43
Kawarabayashi, Younkin, Saido, Shoji, Ashe, Younkin (CR63) 2001; 21
Ru, Kechris, Tabakoff, Hoffman, Radcliffe, Bowler (CR44) 2014; 42
Zhong, Xie, Cao, Wang, Wang, Li (CR50) 2016; 11
Trommer, Shah, Yun, Gamkrelidze, Pasternak, Ye (CR15) 2004; 15
Cao, Hou, Ping, Cai (CR75) 2018; 13
Kanfer, Pettegrew, Moossy, McCartney (CR22) 1993; 18
Kanfer, Singh, Pettegrew, McCartney, Sorrentino (CR23) 1996; 14
Zhu, Nwabuisi-Heath, Dumanis, Tai, Yu, Rebeck (CR18) 2012; 60
Yang, Smith, Zhou, Gandy, Martins (CR7) 1997; 68
Wang, Mandelkow (CR11) 2016; 17
Lane, Raines, Steele, Ehrlich, Lah, Small (CR62) 2010; 30
Goodall, Heath, Bandmann, Kirby, Shaw (CR36) 2013; 7
Yeh, Wang, Tom, Gonzalez, Sheng (CR17) 2016; 91
Howlett, Richardson, Austin, Parsons, Bate, Davies (CR61) 2004; 1017
Fagan, Watson, Parsadanian, Bales, Paul, Holtzman (CR2) 2002; 9
Pettegrew, Panchalingam, Hamilton, McClure (CR20) 2001; 26
Tiraboschi, Hansen, Masliah, Alford, Thal, Corey-Bloom (CR10) 2004; 62
Teter, Xu, Gilbert, Roses, Galasko, Cole (CR14) 1999; 73
Ma, Yee, Brewer, Das, Potter (CR5) 1994; 372
Chan, Oliveira, Cortes, Honig, Duff, Small (CR24) 2012; 287
Wang, Wilson, Moore, Mace, Maeda, Schmechel (CR47) 2005; 18
Miranda, Herman, Cheng, Nahmani, Barrett, Micevska (CR32) 2018; 23
Robinson, Oshlack (CR65) 2010; 11
BL Trommer (824_CR15) 2004; 15
RB Chan (824_CR24) 2012; 287
Z Qiu (824_CR71) 2004; 279
LM Tai (824_CR49) 2017; 58
B Labonte (824_CR58) 2017; 23
H Asai (824_CR74) 2015; 18
MA Passini (824_CR59) 2006; 26
Y Huang (824_CR19) 2014; 72
DE Berman (824_CR27) 2008; 11
GA Elder (824_CR60) 2012; 29
I Berg (824_CR52) 2010; 5
AM Fagan (824_CR2) 2002; 9
A Sierksma (824_CR73) 2018; 13
B Teter (824_CR14) 1999; 73
Y Shi (824_CR9) 2017; 549
H Keren-Shaul (824_CR16) 2017; 169
LB McIntire (824_CR29) 2012; 32
FL Yeh (824_CR17) 2016; 91
F Oyama (824_CR8) 1995; 29
824_CR42
JW Pettegrew (824_CR20) 2001; 26
MR Fabian (824_CR34) 2010; 79
824_CR41
RF Lane (824_CR62) 2010; 30
AM Miranda (824_CR32) 2018; 23
Y Jiang (824_CR3) 2008; 105
WJ Lukiw (824_CR37) 2007; 18
EF Goodall (824_CR36) 2013; 7
C Nasuhoglu (824_CR51) 2002; 301
J Tcw (824_CR54) 2017; 9
R Mayeux (824_CR1) 2003; 26
S Love (824_CR12) 2006; 27
JN Kanfer (824_CR22) 1993; 18
HC Zhu (824_CR67) 2012; 88
T Williams (824_CR76) 2020; 15
SV Voronov (824_CR28) 2008; 105
M Wang (824_CR35) 2019; 10
L Zhu (824_CR43) 2013; 288
Y Liao (824_CR64) 2014; 30
Y Zhu (824_CR18) 2012; 60
J Jordan (824_CR4) 1998; 18
AJ Chicco (824_CR69) 2007; 292
A Shaltouki (824_CR57) 2013; 31
DR Howlett (824_CR61) 2004; 1017
GA Rodriguez (824_CR46) 2013; 20
VF Monteiro-Cardoso (824_CR68) 2015; 43
DA Bennett (824_CR38) 2005; 25
N Wong (824_CR40) 2015; 43
M Antunes (824_CR72) 2012; 13
PK Mandal (824_CR21) 2004; 29
D Balu (824_CR48) 2019; 707
A Subramanian (824_CR66) 2005; 102
JC Cossec (824_CR33) 2012; 21
J Grootendorst (824_CR45) 2005; 159
A Bennett (824_CR39) 2012; 9
J Cao (824_CR75) 2018; 13
J Ma (824_CR5) 1994; 372
C Wang (824_CR47) 2005; 18
C Bardy (824_CR55) 2015; 112
D Paquet (824_CR56) 2016; 533
JN Kanfer (824_CR23) 1996; 14
BP Nathan (824_CR13) 1994; 264
MJ Sharman (824_CR6) 2010; 21
KR Bowles (824_CR53) 2019; 14
L Zhu (824_CR26) 2015; 112
MD Robinson (824_CR65) 2010; 11
P Tiraboschi (824_CR10) 2004; 62
L Zhong (824_CR50) 2016; 11
WE Klunk (824_CR25) 1998; 19
Y Ru (824_CR44) 2014; 42
DS Yang (824_CR7) 1997; 68
Y Wang (824_CR11) 2016; 17
MJ LaDu (824_CR70) 2001; 39
824_CR30
J Cao (824_CR31) 2017; 7
T Kawarabayashi (824_CR63) 2001; 21
References_xml – volume: 23
  start-page: 2967
  year: 2018
  end-page: 75
  ident: CR32
  article-title: Excess Synaptojanin 1 contributes to place cell dysfunction and memory deficits in the aging hippocampus in three types of Alzheimer’s disease
  publication-title: Cell Rep
– volume: 43
  start-page: 1375
  year: 2015
  end-page: 92
  ident: CR68
  article-title: Cardiolipin profile changes are associated to the early synaptic mitochondrial dysfunction in Alzheimer’s disease
  publication-title: J Alzheimer’s Dis: JAD
– volume: 1017
  start-page: 130
  year: 2004
  end-page: 6
  ident: CR61
  article-title: Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes
  publication-title: Brain Res
– volume: 19
  start-page: 511
  year: 1998
  end-page: 5
  ident: CR25
  article-title: Metabolic alterations in postmortem Alzheimer’s disease brain are exaggerated by Apo-E4
  publication-title: Neurobiol aging
– volume: 58
  start-page: 1733
  year: 2017
  end-page: 55
  ident: CR49
  article-title: EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer’s disease
  publication-title: J Lipid Res
– volume: 279
  start-page: 34948
  year: 2004
  end-page: 56
  ident: CR71
  article-title: Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons
  publication-title: J Biol Chem
– volume: 30
  start-page: 923
  year: 2014
  end-page: 30
  ident: CR64
  article-title: FeatureCounts: an efficient general purpose program for assigning sequence reads to genomic features
  publication-title: Bioinformatics
– volume: 18
  start-page: 331
  year: 1993
  end-page: 4
  ident: CR22
  article-title: Alterations of selected enzymes of phospholipid metabolism in Alzheimer’s disease brain tissue as compared to non-Alzheimer’s demented controls
  publication-title: Neurochem Res
– volume: 32
  start-page: 15271
  year: 2012
  end-page: 6
  ident: CR29
  article-title: Reduction of synaptojanin 1 ameliorates synaptic and behavioral impairments in a mouse model of Alzheimer’s disease
  publication-title: J Neurosci: Off J Soc Neurosci
– volume: 21
  start-page: 403
  year: 2010
  end-page: 9
  ident: CR6
  article-title: APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice
  publication-title: J Alzheimer’s Dis: JAD
– volume: 15
  start-page: 8
  year: 2020
  ident: CR76
  article-title: Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease
  publication-title: Mol Neurodegener
– volume: 14
  start-page: 361
  year: 1996
  end-page: 3
  ident: CR23
  article-title: Phospholipid metabolism in Alzheimer’s disease and in a human cholinergic cell
  publication-title: J Lipid Mediat Cell Signal
– volume: 372
  start-page: 92
  year: 1994
  end-page: 4
  ident: CR5
  article-title: Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments
  publication-title: Nature
– volume: 30
  start-page: 13110
  year: 2010
  end-page: 5
  ident: CR62
  article-title: Diabetes-associated SorCS1 regulates Alzheimer’s amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex
  publication-title: J Neurosci: Off J Soc Neurosci
– volume: 264
  start-page: 850
  year: 1994
  end-page: 2
  ident: CR13
  article-title: Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro
  publication-title: Science
– volume: 13
  start-page: 64
  year: 2018
  ident: CR75
  article-title: Advances in developing novel therapeutic strategies for Alzheimer’s disease
  publication-title: Mol Neurodegener
– volume: 9
  start-page: 628
  year: 2012
  end-page: 45
  ident: CR39
  article-title: Overview and findings from the religious orders study
  publication-title: Curr Alzheimer Res
– volume: 60
  start-page: 559
  year: 2012
  end-page: 69
  ident: CR18
  article-title: APOE genotype alters glial activation and loss of synaptic markers in mice
  publication-title: Glia
– ident: CR42
– volume: 11
  start-page: 547
  year: 2008
  end-page: 54
  ident: CR27
  article-title: Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism
  publication-title: Nat Neurosci
– volume: 18
  start-page: 390
  year: 2005
  end-page: 8
  ident: CR47
  article-title: Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology
  publication-title: Neurobiol Dis
– volume: 159
  start-page: 1
  year: 2005
  end-page: 14
  ident: CR45
  article-title: Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior
  publication-title: Behav Brain Res
– volume: 39
  start-page: 427
  year: 2001
  end-page: 34
  ident: CR70
  article-title: Apolipoprotein E and apolipoprotein E receptors modulate A beta-induced glial neuroinflammatory responses
  publication-title: Neurochemistry Int
– volume: 26
  start-page: 81
  year: 2003
  end-page: 104
  ident: CR1
  article-title: Epidemiology of neurodegeneration
  publication-title: Annu Rev Neurosci
– volume: 79
  start-page: 351
  year: 2010
  end-page: 79
  ident: CR34
  article-title: Regulation of mRNA translation and stability by microRNAs
  publication-title: Annu Rev Biochem
– volume: 549
  start-page: 523
  year: 2017
  end-page: 7
  ident: CR9
  article-title: ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
  publication-title: Nature
– volume: 73
  start-page: 2613
  year: 1999
  end-page: 6
  ident: CR14
  article-title: Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture
  publication-title: J Neurochem
– volume: 21
  start-page: 372
  year: 2001
  end-page: 81
  ident: CR63
  article-title: Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer’s disease
  publication-title: J Neurosci: Off J Soc Neurosci
– volume: 5
  start-page: 935
  year: 2010
  end-page: 44
  ident: CR52
  article-title: Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses
  publication-title: Nat Protoc
– volume: 11
  start-page: 2
  year: 2016
  ident: CR50
  article-title: A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism
  publication-title: Mol Neurodegener
– volume: 9
  start-page: 305
  year: 2002
  end-page: 18
  ident: CR2
  article-title: Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer’s disease
  publication-title: Neurobiol Dis
– volume: 533
  start-page: 125
  year: 2016
  end-page: 9
  ident: CR56
  article-title: Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9
  publication-title: Nature
– volume: 26
  start-page: 1334
  year: 2006
  end-page: 42
  ident: CR59
  article-title: Intracranial delivery of CLN2 reduces brain pathology in a mouse model of classical late infantile neuronal ceroid lipofuscinosis
  publication-title: J Neurosci: Off J Soc Neurosci
– volume: 7
  year: 2017
  ident: CR31
  article-title: ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury
  publication-title: Sci Rep
– volume: 29
  start-page: 2273
  year: 2004
  end-page: 9
  ident: CR21
  article-title: Interactions of Abeta(1-40) with glycerophosphocholine and intact erythrocyte membranes: fluorescence and circular dichroism studies
  publication-title: Neurochem Res
– volume: 169
  start-page: 1276
  year: 2017
  end-page: 90 e1217
  ident: CR16
  article-title: A unique microglia type associated with restricting development of Alzheimer’s disease
  publication-title: Cell
– volume: 43
  start-page: D146
  year: 2015
  end-page: 52
  ident: CR40
  article-title: miRDB: an online resource for microRNA target prediction and functional annotations
  publication-title: Nucleic acids Res
– volume: 105
  start-page: 233
  year: 2008
  end-page: 6
  ident: CR3
  article-title: Lack of association between apolipoprotein E promoters in epsilon4 carriers and worsening on computed tomography in early stage of traumatic brain injury
  publication-title: Acta Neurochir Suppl
– volume: 292
  start-page: C33
  year: 2007
  end-page: 44
  ident: CR69
  article-title: Role of cardiolipin alterations in mitochondrial dysfunction and disease
  publication-title: Am J Physiol Cell Physiol
– volume: 18
  start-page: 1584
  year: 2015
  end-page: 93
  ident: CR74
  article-title: Depletion of microglia and inhibition of exosome synthesis halt tau propagation
  publication-title: Nat Neurosci
– volume: 21
  start-page: 3156
  year: 2012
  end-page: 72
  ident: CR33
  article-title: Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes
  publication-title: Hum Mol Genet
– volume: 18
  start-page: 297
  year: 2007
  end-page: 300
  ident: CR37
  article-title: Micro-RNA speciation in fetal, adult and Alzheimer’s disease hippocampus
  publication-title: Neuroreport
– volume: 26
  start-page: 771
  year: 2001
  end-page: 82
  ident: CR20
  article-title: Brain membrane phospholipid alterations in Alzheimer’s disease
  publication-title: Neurochem Res
– volume: 31
  start-page: 941
  year: 2013
  end-page: 52
  ident: CR57
  article-title: Efficient generation of astrocytes from human pluripotent stem cells in defined conditions
  publication-title: Stem Cells
– volume: 11
  year: 2010
  ident: CR65
  article-title: A scaling normalization method for differential expression analysis of RNA-seq data
  publication-title: Genome Biol
– volume: 88
  start-page: 596
  year: 2012
  end-page: 601
  ident: CR67
  article-title: MicroRNA-195 downregulates Alzheimer’s disease amyloid-beta production by targeting BACE1
  publication-title: Brain Res Bull
– volume: 62
  start-page: 1977
  year: 2004
  end-page: 83
  ident: CR10
  article-title: Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease
  publication-title: Neurology
– volume: 18
  start-page: 195
  year: 1998
  end-page: 204
  ident: CR4
  article-title: Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures
  publication-title: J Neurosci: Off J Soc Neurosci
– ident: CR30
– volume: 13
  start-page: 93
  year: 2012
  end-page: 110
  ident: CR72
  article-title: The novel object recognition memory: neurobiology, test procedure, and its modifications
  publication-title: Cogn Process
– volume: 105
  start-page: 9415
  year: 2008
  end-page: 20
  ident: CR28
  article-title: Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down’s syndrome
  publication-title: Proc Natl Acad Sci USA
– volume: 72
  start-page: 3
  issue: Pt A
  year: 2014
  end-page: 12
  ident: CR19
  article-title: structure and function in lipid metabolism, neurobiology, and Alzheimer’s diseases
  publication-title: Neurobiol Dis
– volume: 10
  start-page: 153
  year: 2019
  ident: CR35
  article-title: MicroRNAs in Alzheimer’s disease
  publication-title: Front Genet
– volume: 102
  start-page: 15545
  year: 2005
  end-page: 50
  ident: CR66
  article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
  publication-title: Proc Natl Acad Sci USA
– volume: 17
  start-page: 5
  year: 2016
  end-page: 21
  ident: CR11
  article-title: Tau in physiology and pathology
  publication-title: Nat Rev Neurosci
– volume: 112
  start-page: 11965
  year: 2015
  end-page: 70
  ident: CR26
  article-title: Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesis
  publication-title: Proc Natl Acad Sci USA
– volume: 7
  start-page: 178
  year: 2013
  ident: CR36
  article-title: Neuronal dark matter: the emerging role of microRNAs in neurodegeneration
  publication-title: Front Cell Neurosci
– volume: 112
  start-page: E2725
  year: 2015
  end-page: 34
  ident: CR55
  article-title: Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro
  publication-title: Proc Natl Acad Sci USA
– volume: 27
  start-page: 797
  year: 2006
  end-page: 803
  ident: CR12
  article-title: Premorbid effects of APOE on synaptic proteins in human temporal neocortex
  publication-title: Neurobiol Aging
– volume: 42
  start-page: e133
  year: 2014
  ident: CR44
  article-title: The multiMiR R package and database: integration of microRNA-target interactions along with their disease and drug associations
  publication-title: Nucleic acids Res
– volume: 23
  start-page: 1102
  year: 2017
  end-page: 11
  ident: CR58
  article-title: Sex-specific transcriptional signatures in human depression
  publication-title: Nat Med
– volume: 13
  start-page: 54
  year: 2018
  ident: CR73
  article-title: Deregulation of neuronal miRNAs induced by amyloid-beta or TAU pathology
  publication-title: Mol Neurodegener
– volume: 68
  start-page: 721
  year: 1997
  end-page: 5
  ident: CR7
  article-title: Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma
  publication-title: J neurochemistry
– volume: 20
  start-page: 256
  year: 2013
  end-page: 66
  ident: CR46
  article-title: Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex
  publication-title: Learn Mem
– volume: 29
  start-page: 2564
  year: 2012
  end-page: 75
  ident: CR60
  article-title: Blast exposure induces post-traumatic stress disorder-related traits in a rat model of mild traumatic brain injury
  publication-title: J Neurotrauma
– volume: 29
  start-page: 92
  year: 1995
  end-page: 8
  ident: CR8
  article-title: Apolipoprotein E genotype, Alzheimer’s pathologies and related gene expression in the aged population
  publication-title: Brain Res Mol Brain Res
– volume: 707
  start-page: 134285
  year: 2019
  ident: CR48
  article-title: The role of APOE in transgenic mouse models of AD
  publication-title: Neurosci Lett
– volume: 287
  start-page: 2678
  year: 2012
  end-page: 88
  ident: CR24
  article-title: Comparative lipidomic analysis of mouse and human brain with Alzheimer disease
  publication-title: J Biol Chem
– volume: 14
  start-page: e0213374
  year: 2019
  ident: CR53
  article-title: Reduced variability of neural progenitor cells and improved purity of neuronal cultures using magnetic activated cell sorting
  publication-title: PloS One
– volume: 9
  start-page: 600
  year: 2017
  end-page: 14
  ident: CR54
  article-title: An efficient platform for astrocyte differentiation from human induced pluripotent stem cells
  publication-title: Stem Cell Rep
– volume: 301
  start-page: 243
  year: 2002
  end-page: 54
  ident: CR51
  article-title: Nonradioactive analysis of phosphatidylinositides and other anionic phospholipids by anion-exchange high-performance liquid chromatography with suppressed conductivity detection
  publication-title: Anal Biochem
– volume: 25
  start-page: 163
  year: 2005
  end-page: 75
  ident: CR38
  article-title: The rush memory and aging project: study design and baseline characteristics of the study cohort
  publication-title: Neuroepidemiology
– ident: CR41
– volume: 288
  start-page: 32050
  year: 2013
  end-page: 63
  ident: CR43
  article-title: Reduction of synaptojanin 1 accelerates Abeta clearance and attenuates cognitive deterioration in an Alzheimer mouse model
  publication-title: J Biol Chem
– volume: 91
  start-page: 328
  year: 2016
  end-page: 40
  ident: CR17
  article-title: TREM2 binds to apolipoproteins, including APOE and CLU/APOJ, and thereby facilitates uptake of amyloid-beta by microglia
  publication-title: Neuron
– volume: 15
  start-page: 2655
  year: 2004
  end-page: 8
  ident: CR15
  article-title: ApoE isoform affects LTP in human targeted replacement mice
  publication-title: Neuroreport
– volume: 62
  start-page: 1977
  year: 2004
  ident: 824_CR10
  publication-title: Neurology
  doi: 10.1212/01.WNL.0000128091.92139.0F
– volume: 264
  start-page: 850
  year: 1994
  ident: 824_CR13
  publication-title: Science
  doi: 10.1126/science.8171342
– volume: 29
  start-page: 2564
  year: 2012
  ident: 824_CR60
  publication-title: J Neurotrauma
  doi: 10.1089/neu.2012.2510
– volume: 14
  start-page: 361
  year: 1996
  ident: 824_CR23
  publication-title: J Lipid Mediat Cell Signal
  doi: 10.1016/0929-7855(96)00545-7
– volume: 42
  start-page: e133
  year: 2014
  ident: 824_CR44
  publication-title: Nucleic acids Res
  doi: 10.1093/nar/gku631
– ident: 824_CR41
  doi: 10.1093/bioinformatics/btw002
– volume: 23
  start-page: 2967
  year: 2018
  ident: 824_CR32
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2018.05.011
– volume: 29
  start-page: 92
  year: 1995
  ident: 824_CR8
  publication-title: Brain Res Mol Brain Res
  doi: 10.1016/0169-328X(94)00233-5
– volume: 10
  start-page: 153
  year: 2019
  ident: 824_CR35
  publication-title: Front Genet
  doi: 10.3389/fgene.2019.00153
– volume: 58
  start-page: 1733
  year: 2017
  ident: 824_CR49
  publication-title: J Lipid Res
  doi: 10.1194/jlr.R076315
– volume: 13
  start-page: 93
  year: 2012
  ident: 824_CR72
  publication-title: Cogn Process
  doi: 10.1007/s10339-011-0430-z
– volume: 292
  start-page: C33
  year: 2007
  ident: 824_CR69
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00243.2006
– volume: 21
  start-page: 403
  year: 2010
  ident: 824_CR6
  publication-title: J Alzheimer’s Dis: JAD
  doi: 10.3233/JAD-2010-100141
– volume: 18
  start-page: 195
  year: 1998
  ident: 824_CR4
  publication-title: J Neurosci: Off J Soc Neurosci
  doi: 10.1523/JNEUROSCI.18-01-00195.1998
– volume: 11
  start-page: 2
  year: 2016
  ident: 824_CR50
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-016-0069-4
– volume: 105
  start-page: 233
  year: 2008
  ident: 824_CR3
  publication-title: Acta Neurochir Suppl
  doi: 10.1007/978-3-211-09469-3_45
– volume: 30
  start-page: 923
  year: 2014
  ident: 824_CR64
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt656
– volume: 5
  start-page: 935
  year: 2010
  ident: 824_CR52
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2010.41
– volume: 13
  start-page: 64
  year: 2018
  ident: 824_CR75
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-018-0299-8
– volume: 159
  start-page: 1
  year: 2005
  ident: 824_CR45
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2004.09.019
– volume: 60
  start-page: 559
  year: 2012
  ident: 824_CR18
  publication-title: Glia
  doi: 10.1002/glia.22289
– volume: 112
  start-page: 11965
  year: 2015
  ident: 824_CR26
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1510011112
– volume: 11
  start-page: 547
  year: 2008
  ident: 824_CR27
  publication-title: Nat Neurosci
  doi: 10.1038/nn.2100
– volume: 31
  start-page: 941
  year: 2013
  ident: 824_CR57
  publication-title: Stem Cells
  doi: 10.1002/stem.1334
– volume: 287
  start-page: 2678
  year: 2012
  ident: 824_CR24
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.274142
– volume: 79
  start-page: 351
  year: 2010
  ident: 824_CR34
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev-biochem-060308-103103
– volume: 68
  start-page: 721
  year: 1997
  ident: 824_CR7
  publication-title: J neurochemistry
  doi: 10.1046/j.1471-4159.1997.68020721.x
– volume: 43
  start-page: 1375
  year: 2015
  ident: 824_CR68
  publication-title: J Alzheimer’s Dis: JAD
  doi: 10.3233/JAD-141002
– volume: 23
  start-page: 1102
  year: 2017
  ident: 824_CR58
  publication-title: Nat Med
  doi: 10.1038/nm.4386
– volume: 372
  start-page: 92
  year: 1994
  ident: 824_CR5
  publication-title: Nature
  doi: 10.1038/372092a0
– volume: 7
  year: 2017
  ident: 824_CR31
  publication-title: Sci Rep
– volume: 102
  start-page: 15545
  year: 2005
  ident: 824_CR66
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0506580102
– volume: 18
  start-page: 331
  year: 1993
  ident: 824_CR22
  publication-title: Neurochem Res
  doi: 10.1007/BF00969091
– ident: 824_CR30
  doi: 10.1074/jbc.M113.504365
– volume: 18
  start-page: 297
  year: 2007
  ident: 824_CR37
  publication-title: Neuroreport
  doi: 10.1097/WNR.0b013e3280148e8b
– volume: 9
  start-page: 600
  year: 2017
  ident: 824_CR54
  publication-title: Stem Cell Rep
  doi: 10.1016/j.stemcr.2017.06.018
– volume: 279
  start-page: 34948
  year: 2004
  ident: 824_CR71
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M401055200
– volume: 32
  start-page: 15271
  year: 2012
  ident: 824_CR29
  publication-title: J Neurosci: Off J Soc Neurosci
  doi: 10.1523/JNEUROSCI.2034-12.2012
– volume: 169
  start-page: 1276
  year: 2017
  ident: 824_CR16
  publication-title: Cell
  doi: 10.1016/j.cell.2017.05.018
– volume: 21
  start-page: 372
  year: 2001
  ident: 824_CR63
  publication-title: J Neurosci: Off J Soc Neurosci
  doi: 10.1523/JNEUROSCI.21-02-00372.2001
– volume: 91
  start-page: 328
  year: 2016
  ident: 824_CR17
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.06.015
– volume: 72
  start-page: 3
  issue: Pt A
  year: 2014
  ident: 824_CR19
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2014.08.025
– volume: 30
  start-page: 13110
  year: 2010
  ident: 824_CR62
  publication-title: J Neurosci: Off J Soc Neurosci
  doi: 10.1523/JNEUROSCI.3872-10.2010
– volume: 15
  start-page: 8
  year: 2020
  ident: 824_CR76
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-020-0358-9
– volume: 26
  start-page: 771
  year: 2001
  ident: 824_CR20
  publication-title: Neurochem Res
  doi: 10.1023/A:1011603916962
– volume: 21
  start-page: 3156
  year: 2012
  ident: 824_CR33
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/dds142
– volume: 15
  start-page: 2655
  year: 2004
  ident: 824_CR15
  publication-title: Neuroreport
  doi: 10.1097/00001756-200412030-00020
– volume: 112
  start-page: E2725
  year: 2015
  ident: 824_CR55
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1504393112
– volume: 88
  start-page: 596
  year: 2012
  ident: 824_CR67
  publication-title: Brain Res Bull
  doi: 10.1016/j.brainresbull.2012.05.018
– volume: 73
  start-page: 2613
  year: 1999
  ident: 824_CR14
  publication-title: J Neurochem
  doi: 10.1046/j.1471-4159.1999.0732613.x
– volume: 26
  start-page: 81
  year: 2003
  ident: 824_CR1
  publication-title: Annu Rev Neurosci
  doi: 10.1146/annurev.neuro.26.043002.094919
– volume: 533
  start-page: 125
  year: 2016
  ident: 824_CR56
  publication-title: Nature
  doi: 10.1038/nature17664
– volume: 27
  start-page: 797
  year: 2006
  ident: 824_CR12
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2005.04.008
– volume: 39
  start-page: 427
  year: 2001
  ident: 824_CR70
  publication-title: Neurochemistry Int
  doi: 10.1016/S0197-0186(01)00050-X
– volume: 7
  start-page: 178
  year: 2013
  ident: 824_CR36
  publication-title: Front Cell Neurosci
  doi: 10.3389/fncel.2013.00178
– volume: 14
  start-page: e0213374
  year: 2019
  ident: 824_CR53
  publication-title: PloS One
  doi: 10.1371/journal.pone.0213374
– volume: 301
  start-page: 243
  year: 2002
  ident: 824_CR51
  publication-title: Anal Biochem
  doi: 10.1006/abio.2001.5489
– volume: 20
  start-page: 256
  year: 2013
  ident: 824_CR46
  publication-title: Learn Mem
  doi: 10.1101/lm.030031.112
– volume: 11
  year: 2010
  ident: 824_CR65
  publication-title: Genome Biol
  doi: 10.1186/gb-2010-11-12-144
– volume: 17
  start-page: 5
  year: 2016
  ident: 824_CR11
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn.2015.1
– volume: 707
  start-page: 134285
  year: 2019
  ident: 824_CR48
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2019.134285
– volume: 9
  start-page: 628
  year: 2012
  ident: 824_CR39
  publication-title: Curr Alzheimer Res
  doi: 10.2174/156720512801322573
– volume: 43
  start-page: D146
  year: 2015
  ident: 824_CR40
  publication-title: Nucleic acids Res
  doi: 10.1093/nar/gku1104
– volume: 1017
  start-page: 130
  year: 2004
  ident: 824_CR61
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2004.05.029
– volume: 13
  start-page: 54
  year: 2018
  ident: 824_CR73
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-018-0285-1
– volume: 29
  start-page: 2273
  year: 2004
  ident: 824_CR21
  publication-title: Neurochem Res
  doi: 10.1007/s11064-004-7036-0
– volume: 288
  start-page: 32050
  year: 2013
  ident: 824_CR43
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.504365
– volume: 18
  start-page: 1584
  year: 2015
  ident: 824_CR74
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4132
– volume: 19
  start-page: 511
  year: 1998
  ident: 824_CR25
  publication-title: Neurobiol aging
  doi: 10.1016/S0197-4580(98)00105-5
– volume: 105
  start-page: 9415
  year: 2008
  ident: 824_CR28
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0803756105
– volume: 25
  start-page: 163
  year: 2005
  ident: 824_CR38
  publication-title: Neuroepidemiology
  doi: 10.1159/000087446
– volume: 18
  start-page: 390
  year: 2005
  ident: 824_CR47
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2004.10.013
– volume: 9
  start-page: 305
  year: 2002
  ident: 824_CR2
  publication-title: Neurobiol Dis
  doi: 10.1006/nbdi.2002.0483
– volume: 549
  start-page: 523
  year: 2017
  ident: 824_CR9
  publication-title: Nature
  doi: 10.1038/nature24016
– ident: 824_CR42
  doi: 10.2202/1544-6115.1027
– volume: 26
  start-page: 1334
  year: 2006
  ident: 824_CR59
  publication-title: J Neurosci: Off J Soc Neurosci
  doi: 10.1523/JNEUROSCI.2676-05.2006
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Snippet Our recent findings link the apolipoprotein E4 ( ApoE4 )-specific changes in brain phosphoinositol biphosphate (PIP 2 ) homeostasis to the susceptibility of...
Our recent findings link the apolipoprotein E4 (ApoE4)-specific changes in brain phosphoinositol biphosphate (PIP ) homeostasis to the susceptibility of...
Our recent findings link the apolipoprotein E4 (ApoE4)-specific changes in brain phosphoinositol biphosphate (PIP.sub.2) homeostasis to the susceptibility of...
Our recent findings link the apolipoprotein E4 (ApoE4)-specific changes in brain phosphoinositol biphosphate (PIP2) homeostasis to the susceptibility of...
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Aging
Alzheimer Disease - genetics
Alzheimer's disease
Amyloid beta-Peptides
Animals
Apolipoprotein E
Apolipoprotein E4
Apolipoprotein E4 - genetics
Apolipoproteins
Behavioral Sciences
Biological Psychology
Brain
Brain stem
Cerebrospinal fluid
Cognition
Cognitive ability
Cognitive Dysfunction - genetics
Development and progression
Genetic aspects
Health aspects
Hippocampus
Homeostasis
Humans
Inhibitory postsynaptic potentials
Lysosomes
Medicine
Medicine & Public Health
Mice
Mice, Transgenic
MicroRNA
MicroRNAs
MicroRNAs - genetics
miRNA
Neurodegenerative diseases
Neurosciences
Pathogenesis
Pharmacotherapy
Phenotypes
Phosphatidylinositol 4,5-diphosphate
Phosphorylation
Physiological aspects
Pluripotency
Psychiatry
Stem cell transplantation
Stem cells
Tau protein
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Title MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis
URI https://link.springer.com/article/10.1038/s41380-020-0824-3
https://www.ncbi.nlm.nih.gov/pubmed/32632205
https://www.proquest.com/docview/2596811737
https://www.proquest.com/docview/2421106978
https://pubmed.ncbi.nlm.nih.gov/PMC7785685
Volume 26
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