Serum and macular response to carotenoid-enriched egg supplementation in human subjects: the Egg Xanthophyll Intervention clinical Trial (EXIT)

• Published in: British journal of nutrition Vol. 117; no. 1; pp. 108 - 123
• Main Authors: Kelly, David, Nolan, John M., Howard, Alan N., Stack, Jim, Akuffo, Kwadwo O., Moran, Rachel, Thurnham, David I., Dennison, Jessica, Meagher, Katherine A., Beatty, Stephen
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 14.01.2017
• Subjects: Adult; Bioavailability; blood serum; Carotenoids; Cholesterol; Clinical trials; Diet; Eggs; Eggs - analysis; Female; Food Analysis; Human and Clinical Nutrition; Humans; lutein; Macula Lutea - drug effects; Macular degeneration; Male; Middle Aged; Nutritional Physiological Phenomena; Pigments; tissues; Vision, Ocular - drug effects; Xanthophylls - administration & dosage; Xanthophylls - chemistry; Xanthophylls - pharmacology; zeaxanthin; Zeaxanthin; Lutein; Macular pigment; Meso-zeaxanthin; Serum carotenoids; Carotenoid-enriched eggs; Cholesterol; L lutein; EXIT Egg Xanthophyll Intervention clinical Trial; TZ total zeaxanthin; CisZ cis-zeaxanthin; cpd cycles per degree; MP macular pigment; MZ meso-zeaxanthin; CS contrast sensitivity; WIT Waterford Institute of Technology; BCVA best-corrected visual acuity; Z zeaxanthin

The macular carotenoids lutein (L), zeaxanthin (Z) and meso-zeaxanthin (MZ) accumulate at the macula, where they are collectively referred to as macular pigment (MP). Augmentation of this pigment, typically achieved through diet and supplementation, enhances visual function and protects against prog...