Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites

• Published in: Cell chemical biology Vol. 29; no. 3; pp. 476 - 489.e6
• Main Authors: Lee, Joyce H., Mosher, Eric P., Lee, Young-Sam, Bumpus, Namandjé N., Berger, James M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 17.03.2022
• Subjects: Antineoplastic Agents - pharmacology; cancer; chemotherapy; dexrazoxane; DNA - metabolism; DNA Topoisomerases, Type II - metabolism; DNA topology; etoposide; ICRF-187; metabolism; TCA cycle; topoisomerase; Topoisomerase II Inhibitors - pharmacology; dexrazoxane; DNA topology; ICRF-187; TCA cycle; topoisomerase; cancer; metabolism; etoposide; chemotherapy

Topoisomerase II (topo II) is essential for disentangling newly replicated chromosomes. DNA unlinking involves the physical passage of one duplex through another and depends on the transient formation of double-stranded DNA breaks, a step exploited by frontline chemotherapeutics to kill cancer cells...