A PBPK model to estimate PCDD/F levels in adipose tissue: Comparison with experimental values of residents near a hazardous waste incinerator

• Published in: Environment international Vol. 73; pp. 150 - 157
• Main Authors: Schuhmacher, Marta, Fàbrega, Francesc, Kumar, Vikas, García, Francisco, Nadal, Martí, Domingo, José L.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.12.2014; Elsevier
• Subjects: absorbed dose; Adipose tissue; Adipose Tissue - chemistry; Adult; Aged; Air Pollutants - analysis; Benzofurans - analysis; Biological and medical sciences; breast milk; Dibenzofurans, Polychlorinated; Environment. Living conditions; Environmental pollutants toxicology; Europe; Female; food intake; gender; Hazardous Waste; Hazardous waste incinerator; Humans; Incineration; incinerators; lipid content; Male; Medical sciences; Middle Aged; Milk, Human - chemistry; Models, Biological; PBPK model; PCDD/Fs; Pharmacokinetics; polychlorinated dibenzodioxins; Polychlorinated Dibenzodioxins - analogs & derivatives; Polychlorinated Dibenzodioxins - analysis; polychlorinated dibenzofurans; Public health. Hygiene; Public health. Hygiene-occupational medicine; surveys; Temporal trend; Toxicology; Europe; Adipose tissue; PCDD/Fs; Hazardous waste incinerator; PBPK model; Temporal trend; Human; Proximity; Estimation; Hazardous waste; Concentration; Experimental study; Time variation; Toxicokinetics; Compartmental model; Incinerator; Resident; Comparative study

This study was aimed at determining the concentrations of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) in 15 samples of adipose tissue from subjects who had been living in the vicinity of a hazardous waste incinerator (HWI). The results were compared with levels obta...