Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

• Published in: Oncogene Vol. 38; no. 7; pp. 998 - 1018
• Main Authors: Szmyd, Radoslaw, Niska-Blakie, Joanna, Diril, M. Kasim, Renck Nunes, Patrícia, Tzelepis, Konstantinos, Lacroix, Aurélie, van Hul, Noémi, Deng, Lih-Wen, Matos, Joao, Dreesen, Oliver, Bisteau, Xavier, Kaldis, Philipp
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2019; Nature Publishing Group
• Subjects: 13/1; 13/106; 13/31; 13/89; 42/41; 631/67/70; 631/80/641/1655; 64/60; 96/95; Amino Acid Substitution; Animals; Antineoplastic agents; Apoptosis; Cancer; Cancer treatment; Carcinogenesis; CDC2 Protein Kinase - genetics; CDC2 Protein Kinase - metabolism; Cell Biology; Cell cycle; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell proliferation; Cellular signal transduction; Clinical trials; Cyclin-dependent kinase 2; Cyclin-dependent kinases; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA damage; DNA replication; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Embryo fibroblasts; Embryo Loss - enzymology; Embryo Loss - genetics; Embryo Loss - pathology; Embryo, Mammalian - enzymology; Embryo, Mammalian - pathology; Embryos; Endonuclease; Enzyme Activation; Genetic aspects; Genomes; Genomics; Health aspects; Human Genetics; Intelligence gathering; Internal Medicine; Kinases; Lethality; Liver; Medicine; Medicine & Public Health; Mice; Mice, Transgenic; Mitosis; Mutation, Missense; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Nucleases; Oncology; p53 Protein; Phosphorylation; Phosphotransferases; Protein-Tyrosine Kinases - genetics; Protein-Tyrosine Kinases - metabolism; S Phase; Transcription Factors - genetics; Transcription Factors - metabolism; Tumor proteins; Tumors

Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin complexes drive most processes in cellular proliferation. In response to DNA damage, cell cycle surveillance mechanisms enable normal cells to arrest...