Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin complexes drive most processes in cellular proliferation. In response to DNA damage, cell cycle surveillance mechanisms enable normal cells to arrest...

Full description

Saved in:
Bibliographic Details
Published inOncogene Vol. 38; no. 7; pp. 998 - 1018
Main Authors Szmyd, Radoslaw, Niska-Blakie, Joanna, Diril, M. Kasim, Renck Nunes, Patrícia, Tzelepis, Konstantinos, Lacroix, Aurélie, van Hul, Noémi, Deng, Lih-Wen, Matos, Joao, Dreesen, Oliver, Bisteau, Xavier, Kaldis, Philipp
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.02.2019
Nature Publishing Group
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin complexes drive most processes in cellular proliferation. In response to DNA damage, cell cycle surveillance mechanisms enable normal cells to arrest and undergo repair processes. Perturbations in genomic stability can lead to tumor development and suggest that cell cycle regulators could be effective targets in anticancer therapy. However, many clinical trials ended in failure due to off-target effects of the inhibitors used. Here, we investigate in vivo the importance of WEE1- and MYT1-dependent inhibitory phosphorylation of mammalian CDK1. We generated Cdk1 AF knockin mice, in which two inhibitory phosphorylation sites are replaced by the non-phosphorylatable amino acids T14A/Y15F. We uncovered that monoallelic expression of CDK1 AF is early embryonic lethal in mice and induces S phase arrest accompanied by γH2AX and DNA damage checkpoint activation in mouse embryonic fibroblasts (MEFs). The chromosomal fragmentation in Cdk1 AF MEFs does not rely on CDK2 and is partly caused by premature activation of MUS81-SLX4 structure-specific endonuclease complexes, as well as untimely onset of chromosome condensation followed by nuclear lamina disassembly. We provide evidence that tumor development in liver expressing CDK1 AF is inhibited. Interestingly, the regulatory mechanisms that impede cell proliferation in CDK1 AF expressing cells differ partially from the actions of the WEE1 inhibitor, MK-1775, with p53 expression determining the sensitivity of cells to the drug response. Thus, our work highlights the importance of improved therapeutic strategies for patients with various cancer types and may explain why some patients respond better to WEE1 inhibitors.
AbstractList Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin complexes drive most processes in cellular proliferation. In response to DNA damage, cell cycle surveillance mechanisms enable normal cells to arrest and undergo repair processes. Perturbations in genomic stability can lead to tumor development and suggest that cell cycle regulators could be effective targets in anticancer therapy. However, many clinical trials ended in failure due to off-target effects of the inhibitors used. Here, we investigate in vivo the importance of WEE1- and MYT1-dependent inhibitory phosphorylation of mammalian CDK1. We generated Cdk1 knockin mice, in which two inhibitory phosphorylation sites are replaced by the non-phosphorylatable amino acids T14A/Y15F. We uncovered that monoallelic expression of CDK1 is early embryonic lethal in mice and induces S phase arrest accompanied by γH2AX and DNA damage checkpoint activation in mouse embryonic fibroblasts (MEFs). The chromosomal fragmentation in Cdk1 MEFs does not rely on CDK2 and is partly caused by premature activation of MUS81-SLX4 structure-specific endonuclease complexes, as well as untimely onset of chromosome condensation followed by nuclear lamina disassembly. We provide evidence that tumor development in liver expressing CDK1 is inhibited. Interestingly, the regulatory mechanisms that impede cell proliferation in CDK1 expressing cells differ partially from the actions of the WEE1 inhibitor, MK-1775, with p53 expression determining the sensitivity of cells to the drug response. Thus, our work highlights the importance of improved therapeutic strategies for patients with various cancer types and may explain why some patients respond better to WEE1 inhibitors.
Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin complexes drive most processes in cellular proliferation. In response to DNA damage, cell cycle surveillance mechanisms enable normal cells to arrest and undergo repair processes. Perturbations in genomic stability can lead to tumor development and suggest that cell cycle regulators could be effective targets in anticancer therapy. However, many clinical trials ended in failure due to off-target effects of the inhibitors used. Here, we investigate in vivo the importance of WEE1- and MYT1-dependent inhibitory phosphorylation of mammalian CDK1. We generated Cdk1AF knockin mice, in which two inhibitory phosphorylation sites are replaced by the non-phosphorylatable amino acids T14A/Y15F. We uncovered that monoallelic expression of CDK1AF is early embryonic lethal in mice and induces S phase arrest accompanied by γH2AX and DNA damage checkpoint activation in mouse embryonic fibroblasts (MEFs). The chromosomal fragmentation in Cdk1AF MEFs does not rely on CDK2 and is partly caused by premature activation of MUS81-SLX4 structure-specific endonuclease complexes, as well as untimely onset of chromosome condensation followed by nuclear lamina disassembly. We provide evidence that tumor development in liver expressing CDK1AF is inhibited. Interestingly, the regulatory mechanisms that impede cell proliferation in CDK1AF expressing cells differ partially from the actions of the WEE1 inhibitor, MK-1775, with p53 expression determining the sensitivity of cells to the drug response. Thus, our work highlights the importance of improved therapeutic strategies for patients with various cancer types and may explain why some patients respond better to WEE1 inhibitors.
Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin complexes drive most processes in cellular proliferation. In response to DNA damage, cell cycle surveillance mechanisms enable normal cells to arrest and undergo repair processes. Perturbations in genomic stability can lead to tumor development and suggest that cell cycle regulators could be effective targets in anticancer therapy. However, many clinical trials ended in failure due to off-target effects of the inhibitors used. Here, we investigate in vivo the importance of WEE1- and MYT1-dependent inhibitory phosphorylation of mammalian CDK1. We generated Cdk1.sup.AF knockin mice, in which two inhibitory phosphorylation sites are replaced by the non-phosphorylatable amino acids T14A/Y15F. We uncovered that monoallelic expression of CDK1.sup.AF is early embryonic lethal in mice and induces S phase arrest accompanied by [gamma]H2AX and DNA damage checkpoint activation in mouse embryonic fibroblasts (MEFs). The chromosomal fragmentation in Cdk1.sup.AF MEFs does not rely on CDK2 and is partly caused by premature activation of MUS81-SLX4 structure-specific endonuclease complexes, as well as untimely onset of chromosome condensation followed by nuclear lamina disassembly. We provide evidence that tumor development in liver expressing CDK1.sup.AF is inhibited. Interestingly, the regulatory mechanisms that impede cell proliferation in CDK1.sup.AF expressing cells differ partially from the actions of the WEE1 inhibitor, MK-1775, with p53 expression determining the sensitivity of cells to the drug response. Thus, our work highlights the importance of improved therapeutic strategies for patients with various cancer types and may explain why some patients respond better to WEE1 inhibitors.
Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin complexes drive most processes in cellular proliferation. In response to DNA damage, cell cycle surveillance mechanisms enable normal cells to arrest and undergo repair processes. Perturbations in genomic stability can lead to tumor development and suggest that cell cycle regulators could be effective targets in anticancer therapy. However, many clinical trials ended in failure due to off-target effects of the inhibitors used. Here, we investigate in vivo the importance of WEE1- and MYT1-dependent inhibitory phosphorylation of mammalian CDK1. We generated Cdk1 AF knockin mice, in which two inhibitory phosphorylation sites are replaced by the non-phosphorylatable amino acids T14A/Y15F. We uncovered that monoallelic expression of CDK1 AF is early embryonic lethal in mice and induces S phase arrest accompanied by γH2AX and DNA damage checkpoint activation in mouse embryonic fibroblasts (MEFs). The chromosomal fragmentation in Cdk1 AF MEFs does not rely on CDK2 and is partly caused by premature activation of MUS81-SLX4 structure-specific endonuclease complexes, as well as untimely onset of chromosome condensation followed by nuclear lamina disassembly. We provide evidence that tumor development in liver expressing CDK1 AF is inhibited. Interestingly, the regulatory mechanisms that impede cell proliferation in CDK1 AF expressing cells differ partially from the actions of the WEE1 inhibitor, MK-1775, with p53 expression determining the sensitivity of cells to the drug response. Thus, our work highlights the importance of improved therapeutic strategies for patients with various cancer types and may explain why some patients respond better to WEE1 inhibitors.
Audience Academic
Author Renck Nunes, Patrícia
Matos, Joao
Bisteau, Xavier
Szmyd, Radoslaw
Deng, Lih-Wen
Diril, M. Kasim
Dreesen, Oliver
Kaldis, Philipp
Tzelepis, Konstantinos
Lacroix, Aurélie
van Hul, Noémi
Niska-Blakie, Joanna
Author_xml – sequence: 1
  givenname: Radoslaw
  surname: Szmyd
  fullname: Szmyd, Radoslaw
  organization: Institute of Molecular and Cell Biology (IMCB), ASTAR (Agency for Science, Technology and Research), National University of Singapore (NUS), NUS Graduate School for Integrative Sciences and Engineering
– sequence: 2
  givenname: Joanna
  surname: Niska-Blakie
  fullname: Niska-Blakie, Joanna
  organization: Institute of Molecular and Cell Biology (IMCB), ASTAR (Agency for Science, Technology and Research), Bioinformatics Institute (BII), ASTAR
– sequence: 3
  givenname: M. Kasim
  surname: Diril
  fullname: Diril, M. Kasim
  organization: Institute of Molecular and Cell Biology (IMCB), ASTAR (Agency for Science, Technology and Research), Izmir Biomedicine and Genome Institute, Dokuz Eylul University
– sequence: 4
  givenname: Patrícia
  surname: Renck Nunes
  fullname: Renck Nunes, Patrícia
  organization: Institute of Molecular and Cell Biology (IMCB), ASTAR (Agency for Science, Technology and Research), Ecole Polytechnique Federale de Lausanne, School of Life Sciences
– sequence: 5
  givenname: Konstantinos
  surname: Tzelepis
  fullname: Tzelepis, Konstantinos
  organization: Institute of Molecular and Cell Biology (IMCB), ASTAR (Agency for Science, Technology and Research), Wellcome Trust Sanger Institute
– sequence: 6
  givenname: Aurélie
  surname: Lacroix
  fullname: Lacroix, Aurélie
  organization: Institute of Molecular and Cell Biology (IMCB), ASTAR (Agency for Science, Technology and Research), Department of Chemistry and Centre for Self-Assembled Chemical Structures (CSACS), McGill University
– sequence: 7
  givenname: Noémi
  surname: van Hul
  fullname: van Hul, Noémi
  organization: Institute of Molecular and Cell Biology (IMCB), ASTAR (Agency for Science, Technology and Research)
– sequence: 8
  givenname: Lih-Wen
  surname: Deng
  fullname: Deng, Lih-Wen
  organization: National University of Singapore (NUS), Department of Biochemistry
– sequence: 9
  givenname: Joao
  surname: Matos
  fullname: Matos, Joao
  organization: ETH Zürich, Department of Biology
– sequence: 10
  givenname: Oliver
  surname: Dreesen
  fullname: Dreesen, Oliver
  organization: Institute of Medical Biology, ASTAR
– sequence: 11
  givenname: Xavier
  surname: Bisteau
  fullname: Bisteau, Xavier
  organization: Institute of Molecular and Cell Biology (IMCB), ASTAR (Agency for Science, Technology and Research)
– sequence: 12
  givenname: Philipp
  orcidid: 0000-0002-7247-7591
  surname: Kaldis
  fullname: Kaldis, Philipp
  email: kaldis@imcb.a-star.edu.sg
  organization: Institute of Molecular and Cell Biology (IMCB), ASTAR (Agency for Science, Technology and Research), National University of Singapore (NUS), Department of Biochemistry
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30190546$$D View this record in MEDLINE/PubMed
BookMark eNp1kl1rVDEQhoNU7Lb6A7yRgDfenJqP85FzI5RFW6GgoOJlyDmZ7Kaek6xJdmH_vbNsba0oIQxknvdNJjNn5CTEAIS85OyCM6ne5ppLpSrGcddtXbEnZMHrrq2apq9PyIL1Dat6IcUpOcv5ljHW9Uw8I6eS8Z41dbsg3z8nmE3ZJqBmLH5nio-BRkeX9genExibaYl09iUWP1LYQSiZ-kC_0M3aZFQFS2Ee0j4GzE9Q1mbyZf-cPHVmyvDiLp6Tbx_ef11eVzefrj4uL2-qsZFdqVQnGtspBQOXlhtrBmn7rh2VATs4xaxsDBLQcowOnGuldGpgSLfGdEaek3dH3812mMGO-LxkJr1JfjZpr6Px-nEm-LVexZ1uu6blokGDN3cGKf7cQi569nmEaTIB4jZrwRkXncSfRvT1X-ht3KaA5SGlWK-E6PsHamUm0D64iPeOB1N92XS1YIrxGqmLf1C4LMx-xDY7j-ePBPwoGFPMOYG7r5EzfZgGfZwGjdOgD9OgGWpe_fk594rf7UdAHIGMqbCC9FDR_11_ARW7wR4
CitedBy_id crossref_primary_10_1021_acs_jproteome_2c00706
crossref_primary_10_1242_dev_180273
crossref_primary_10_1158_1078_0432_CCR_21_1010
crossref_primary_10_4103_MJBL_MJBL_34_22
crossref_primary_10_1007_s12072_020_10066_6
crossref_primary_10_1242_jcs_261364
crossref_primary_10_1128_JVI_00130_19
crossref_primary_10_1016_j_celrep_2022_111537
crossref_primary_10_1016_j_gene_2020_145105
crossref_primary_10_1158_1541_7786_MCR_19_0585
crossref_primary_10_1038_s41467_023_37761_w
crossref_primary_10_3389_fonc_2023_1130911
crossref_primary_10_1186_s13045_020_00959_2
crossref_primary_10_1016_j_dnarep_2021_103156
crossref_primary_10_1158_2767_9764_CRC_22_0130
crossref_primary_10_15252_embj_201899692
crossref_primary_10_1083_jcb_201806057
crossref_primary_10_3389_fgene_2021_784167
crossref_primary_10_3389_fcell_2021_770939
crossref_primary_10_1021_acschembio_2c00527
crossref_primary_10_1016_j_cellsig_2023_110723
crossref_primary_10_3390_cancers14194952
crossref_primary_10_1007_s12031_020_01587_8
crossref_primary_10_3390_app13137351
crossref_primary_10_1101_gad_349596_122
crossref_primary_10_1038_s44321_024_00060_y
crossref_primary_10_1172_JCI161544
crossref_primary_10_15252_embj_2021108486
crossref_primary_10_1038_s41598_021_82551_3
crossref_primary_10_1016_j_semcdb_2020_04_003
crossref_primary_10_1038_s41586_022_04638_9
crossref_primary_10_1002_bies_202000105
crossref_primary_10_1002_pmic_202300088
crossref_primary_10_1083_jcb_201909032
crossref_primary_10_1158_1535_7163_MCT_20_0848
crossref_primary_10_1002_jmv_28725
crossref_primary_10_3389_fonc_2023_1216131
crossref_primary_10_1016_j_isci_2022_105806
crossref_primary_10_1016_j_bbrc_2023_08_010
crossref_primary_10_1128_MCB_00333_20
crossref_primary_10_1021_acs_jproteome_2c00168
crossref_primary_10_3892_ijo_2021_5264
crossref_primary_10_1016_j_bmcl_2022_128636
crossref_primary_10_3389_fonc_2022_828684
crossref_primary_10_1016_j_cbi_2022_110056
crossref_primary_10_1073_pnas_2013921117
crossref_primary_10_1016_j_dnarep_2021_103261
crossref_primary_10_3390_genes9120634
crossref_primary_10_1139_bcb_2020_0395
Cites_doi 10.1016/S0003-9861(03)00010-9
10.1126/science.1384126
10.1038/sj.bjc.6604208
10.1093/nar/27.22.4324
10.1002/1873-3468.12727
10.18632/oncotarget.4583
10.1073/pnas.0600447103
10.1091/mbc.e03-03-0168
10.1016/j.ccell.2015.09.015
10.1158/0008-5472.CAN-04-1613
10.1128/MCB.00952-08
10.1074/jbc.270.38.22527
10.1038/onc.2012.504
10.1073/pnas.1302927110
10.1083/jcb.153.3.613
10.1093/embo-reports/kve064
10.1128/MCB.06721-11
10.1038/onc.2012.296
10.1038/nature06046
10.1083/jcb.121.1.101
10.1101/gad.2053211
10.1002/(SICI)1526-968X(200002)26:2<149::AID-GENE16>3.0.CO;2-V
10.1091/mbc.11.5.1597
10.7150/ijbs.2.161
10.1074/jbc.271.22.13283
10.1038/366701a0
10.1126/science.1244508
10.1016/j.cub.2006.11.066
10.1038/ncb1708
10.1101/gad.585310
10.1038/cr.2016.119
10.1002/j.1460-2075.1991.tb04897.x
10.1101/cshperspect.a012914
10.1073/pnas.1505283112
10.1158/1535-7163.MCT-09-0463
10.1101/gad.12.6.806
10.1126/science.288.5470.1425
10.1146/annurev.cellbio.13.1.261
10.1084/jem.194.9.1313
10.1016/0092-8674(90)90470-Y
10.1158/1078-0432.CCR-13-2858
10.1016/j.molcel.2009.06.036
10.1101/gad.238303.114
10.1016/j.tips.2016.06.006
10.1083/jcb.151.7.1381
10.1038/nature02253
10.1091/mbc.e08-02-0172
10.1002/j.1460-2075.1993.tb05633.x
10.1073/pnas.0506252102
10.1073/pnas.89.7.2917
10.1126/science.282.5393.1497
10.1007/s000180050290
10.1038/nature07433
10.1016/0092-8674(90)90469-U
10.1016/0092-8674(91)90315-P
10.1038/nsmb1313
10.1126/science.270.5233.86
10.1016/j.cell.2011.08.032
10.1016/j.molcel.2004.11.038
10.1101/gad.14.3.328
10.1074/jbc.M306683200
10.1038/357128a0
10.1002/j.1460-2075.1992.tb05135.x
10.1111/j.1768-322X.1999.tb01111.x
10.1158/2159-8290.CD-11-0320
10.1016/0092-8674(93)80048-J
10.1016/S0021-9258(18)32656-5
10.1016/S0092-8674(00)81871-1
10.1016/j.devcel.2016.11.017
10.1128/MCB.17.2.571
10.1101/cshperspect.a008656
10.1111/j.1768-322X.1998.tb01068.x
10.1006/dbio.2002.0597
10.1002/j.1460-2075.1991.tb04896.x
10.1091/mbc.e11-02-0136
10.1007/s00412-010-0291-8
10.1083/jcb.201101047
10.1101/sqb.2015.80.027649
10.1016/0092-8674(91)90266-2
10.1016/j.drudis.2011.12.009
10.1038/35007104
10.1093/nar/23.18.3613
10.1128/MCB.00412-12
10.1083/jcb.112.5.797
10.1242/jcs.100883
10.1016/0092-8674(90)90599-A
10.1091/mbc.3.1.13
10.1074/jbc.M300070200
10.1016/j.molcel.2013.08.035
10.1002/gene.20039
10.1038/sj.bjc.6604874
10.1016/j.cub.2003.09.024
10.1038/ncb757
10.1038/nprot.2007.471
10.1073/pnas.0602400103
10.1038/nrm2852
10.1016/0092-8674(91)90583-K
10.1242/jcs.112.19.3361
10.1016/S0092-8674(00)81322-7
10.1016/0092-8674(90)90471-P
10.1038/nature14285
10.1091/mbc.8.6.1013
10.1016/j.leukres.2017.11.004
10.1091/mbc.5.3.273
10.1038/35007110
10.1074/jbc.M607910200
10.1101/SQB.1997.062.01.021
10.1073/pnas.1115201109
10.1016/0092-8674(91)90117-H
10.1016/j.celrep.2013.08.041
10.1016/0092-8674(93)90499-G
10.1038/351242a0
10.1128/MCB.21.5.1719-1729.2001
10.1073/pnas.94.11.5611
10.1083/jcb.141.4.875
10.1074/jbc.273.16.9357
10.1083/jcb.134.4.963
ContentType Journal Article
Copyright The Author(s) 2018
COPYRIGHT 2019 Nature Publishing Group
2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2018
– notice: COPYRIGHT 2019 Nature Publishing Group
– notice: 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7TM
7TO
7U9
7X7
7XB
88A
88E
8AO
8C1
8FD
8FE
8FH
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
GUQSH
H94
HCIFZ
K9.
LK8
M0S
M1P
M2O
M7P
MBDVC
P64
PQEST
PQQKQ
PQUKI
PRINS
Q9U
RC3
7X8
5PM
DOI 10.1038/s41388-018-0464-0
DatabaseName Springer Nature OA/Free Journals*
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Virology and AIDS Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
Medical Database
Research Library
Biological Science Database
Research Library (Corporate)
Biotechnology and BioEngineering Abstracts
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Research Library Prep
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
Technology Research Database
ProQuest Central Essentials
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
Genetics Abstracts
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
AIDS and Cancer Research Abstracts
ProQuest Research Library
ProQuest Medical Library (Alumni)
ProQuest Public Health
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE
Research Library Prep



Database_xml – sequence: 1
  dbid: C6C
  name: SpringerOpen
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Biology
EISSN 1476-5594
EndPage 1018
ExternalDocumentID A574208014
10_1038_s41388_018_0464_0
30190546
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: A*STAR | Institute of Molecular and Cell Biology (Institute of Molecular and Cell Biology - A STAR)
  grantid: core
  funderid: https://doi.org/10.13039/501100007674
– fundername: A*STAR | Institute of Molecular and Cell Biology (Institute of Molecular and Cell Biology - A STAR)
  grantid: core
– fundername: ;
  grantid: core
GroupedDBID ---
-Q-
0R~
123
29N
2WC
36B
39C
4.4
406
53G
5RE
70F
7X7
88A
88E
8AO
8C1
8FE
8FH
8FI
8FJ
8G5
8R4
8R5
AACDK
AANZL
AASML
AATNV
AAWBL
AAZLF
ABAKF
ABJNI
ABLJU
ABUWG
ABZZP
ACAOD
ACGFO
ACGFS
ACKTT
ACMJI
ACPRK
ACRQY
ACZOJ
ADBBV
ADFRT
ADHDB
AEJRE
AEMSY
AENEX
AEVLU
AEXYK
AFBBN
AFKRA
AFSHS
AGEZK
AGHAI
AGQEE
AHMBA
AHSBF
AIGIU
AILAN
AJRNO
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMYLF
ASPBG
AVWKF
AXYYD
AZFZN
AZQEC
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
C6C
CCPQU
CS3
DIK
DNIVK
DPUIP
DU5
DWQXO
E3Z
EAP
EBLON
EBS
EE.
EIOEI
EJD
ESX
F5P
FDQFY
FEDTE
FERAY
FIGPU
FIZPM
FSGXE
FYUFA
GNUQQ
GUQSH
HCIFZ
HMCUK
HVGLF
HZ~
IAO
IHR
INH
INR
ITC
IWAJR
JSO
JZLTJ
KQ8
L7B
LGEZI
LK8
LOTEE
M0L
M1P
M2O
M7P
N9A
NADUK
NQJWS
NXXTH
O9-
OK1
P2P
PQQKQ
PROAC
PSQYO
Q2X
RNT
RNTTT
SNX
SNYQT
SOHCF
SRMVM
SWTZT
TAOOD
TBHMF
TDRGL
TSG
UKHRP
WH7
.55
.GJ
3O-
3V.
AAYZH
ABAWZ
ABDBF
ABEFU
AEFQL
AFFNX
B0M
BAWUL
CAG
CGR
COF
CUY
CVF
EAD
EBC
EBD
ECM
EIF
EMB
EMK
EMOBN
EPL
FRP
NAO
NPM
OVD
RNS
SV3
TEORI
TR2
TUS
UDS
W2D
X7M
ZXP
~8M
AAYXX
CITATION
7TM
7TO
7U9
7XB
8FD
8FK
FR3
H94
K9.
MBDVC
P64
PQEST
PQUKI
PRINS
Q9U
RC3
7X8
5PM
ID FETCH-LOGICAL-c537t-8725d788eb13d1adab3d976c8aedbf80d35a25de615a2feff633f8b013d6aa7a3
IEDL.DBID C6C
ISSN 0950-9232
IngestDate Tue Sep 17 21:15:31 EDT 2024
Fri Oct 25 01:06:27 EDT 2024
Thu Oct 10 17:01:04 EDT 2024
Tue Nov 19 21:12:12 EST 2024
Tue Nov 12 23:17:03 EST 2024
Thu Nov 21 22:21:40 EST 2024
Wed Oct 16 00:50:45 EDT 2024
Fri Oct 11 20:50:37 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c537t-8725d788eb13d1adab3d976c8aedbf80d35a25de615a2feff633f8b013d6aa7a3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-7247-7591
OpenAccessLink https://doi.org/10.1038/s41388-018-0464-0
PMID 30190546
PQID 2180982299
PQPubID 36330
PageCount 21
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_6756125
proquest_miscellaneous_2101273413
proquest_journals_2180982299
gale_infotracmisc_A574208014
gale_infotracacademiconefile_A574208014
crossref_primary_10_1038_s41388_018_0464_0
pubmed_primary_30190546
springer_journals_10_1038_s41388_018_0464_0
PublicationCentury 2000
PublicationDate 2019-02-00
PublicationDateYYYYMMDD 2019-02-01
PublicationDate_xml – month: 02
  year: 2019
  text: 2019-02-00
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
– name: New York
PublicationTitle Oncogene
PublicationTitleAbbrev Oncogene
PublicationTitleAlternate Oncogene
PublicationYear 2019
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Monaco, Kolthur-Seetharam, Loury, Murcia, de Murcia, Sassone-Corsi (CR72) 2005; 102
Xiong, Hannon, Zhang, Casso, Kobayashi, Beach (CR96) 1993; 366
Beck, Nahse-Kumpf, Larsen, O’Hanlon, Patzke, Holmberg (CR34) 2012; 32
Zhao, Chen, Gurian-West, Roberts (CR107) 2012; 32
Santamaria, Barriere, Cerqueira, Hunt, Tardy, Newton (CR1) 2007; 448
Morgan (CR3) 1997; 13
Fukuda, Morioka, Imajou, Ikeda, Ohtsuka, Tsurimoto (CR59) 1995; 270
Gautier, Minshull, Lohka, Glotzer, Hunt, Maller (CR63) 1990; 60
Schultz, Chehab, Malikzay, Halazonetis (CR81) 2000; 151
Ho, Lim, Lee, Steinberg, Szmyd, Tham (CR102) 2015; 6
Vassilev, Tovar, Chen, Knezevic, Zhao, Sun (CR48) 2006; 103
Duda, Arter, Gloggnitzer, Teloni, Wild, Blanco (CR91) 2016; 39
Dominguez-Kelly, Martin, Koundrioukoff, Tanenbaum, Smits, Medema (CR41) 2011; 194
Chow, Siu, Fung, Chan, Lau, Arooz (CR30) 2003; 14
Scaffidi, Misteli (CR78) 2008; 10
Bowers, Randell, Chen, Bell (CR55) 2004; 16
Klotz-Noack, McIntosh, Schurch, Pratt, Blow (CR120) 2012; 125
Ward, Kirschner (CR76) 1990; 61
Lewandoski, Meyers, Martin (CR114) 1997; 62
Heijink, Blomen, Bisteau, Degener, Matsushita, Kaldis (CR35) 2015; 112
Bell, Stillman (CR49) 1992; 357
Pfister, Markkanen, Jiang, Sarkar, Woodcock, Orlando (CR37) 2015; 28
Lohka (CR62) 1998; 90
Pagano, Pepperkok, Verde, Ansorge, Draetta (CR66) 1992; 11
Wu, Hickson (CR88) 2003; 426
Matos, Blanco, Maslen, Skehel, West (CR90) 2011; 147
Tanaka, Araki (CR56) 2010; 119
Solomon, Lee, Kirschner (CR8) 1992; 3
Johnson, Cai, Kennedy, Pathania, Arora, Li (CR28) 2009; 35
Garcia, Fosmire, Porter (CR38) 2018; 64
Heald, McLoughlin, McKeon (CR11) 1993; 74
Matheson, Backos, Reigan (CR33) 2016; 37
Bucher, Britten (CR31) 2008; 98
Pomerening, Ubersax, Ferrell (CR44) 2008; 19
Mueller, Coleman, Kumagai, Dunphy (CR4) 1995; 270
Woo, Hakem, Soengas, Duncan, Shahinian, Kagi (CR84) 1998; 12
Vooijs, Jonkers, Berns (CR115) 2001; 2
Kornbluth, Sebastian, Hunter, Newport (CR5) 1994; 5
Berthet, Aleem, Coppola, Tessarollo, Kaldis (CR47) 2003; 13
Hayashi, McMahon (CR116) 2002; 244
Chow, Siu, Ho, Ma, Ho, Poon (CR36) 2003; 278
Padmakumar, Aleem, Berthet, Hilton, Kaldis (CR100) 2009; 29
Chen, Stephens, Middleton, Curtin (CR32) 2012; 17
McGowan, Russell (CR12) 1993; 12
Peter, Nakagawa, Doree, Labbe, Nigg (CR71) 1990; 61
Moser, Xu, Kao, Annis, Lerma, Schaupp (CR109) 2014; 20
Wyatt, Sarbajna, Matos, West (CR92) 2013; 52
Ross, Kaldis, Solomon (CR67) 2000; 11
Postic, Magnuson (CR117) 2000; 26
Yeeles, Deegan, Janska, Early, Diffley (CR57) 2015; 519
Coleman, Carpenter, Dunphy (CR50) 1996; 87
Parker, Piwnica-Worms (CR7) 1992; 257
Maiorano, Moreau, Mechali (CR52) 2000; 404
Levine (CR99) 1997; 88
Hughes, Sidorova, Swanger, Monnat, Clurman (CR106) 2013; 110
Jin, Hardy, Morgan (CR43) 1998; 141
Waldman, Kinzler, Vogelstein (CR98) 1995; 55
Lundgren, Walworth, Booher, Dembski, Kirschner, Beach (CR68) 1991; 64
Branzei, Foiani (CR61) 2010; 11
Kao, Marto, Hoffmann, Shabanowitz, Finkelstein, Whiteside (CR21) 2001; 194
Bunz, Dutriaux, Lengauer, Waldman, Zhou, Brown (CR97) 1998; 282
Kumagai, Dunphy (CR16) 1991; 64
Krajewska, Heijink, Bisselink, Seinstra, Sillje, de Vries (CR40) 2013; 32
Wilkins, Rall, Ostwal, Kruitwagen, Hiragami-Hamada, Winkler (CR73) 2014; 343
Enoch, Peter, Nurse, Nigg (CR70) 1991; 112
Gong, Pomerening, Myers, Gustavsson, Jones, Hahn (CR69) 2007; 17
Blasina, Paegle, McGowan (CR103) 1997; 8
Adhikari, Busayavalasa, Zhang, Hu, Risal, Bayazit (CR45) 2016; 26
Wells, Watanabe, Tokusumi, Jiang, Verdecia, Hunter (CR14) 1999; 112
Coulonval, Kooken, Roger (CR13) 2011; 22
Mailand, Falck, Lukas, Syljuasen, Welcker, Bartek (CR22) 2000; 288
Fang, Newport (CR64) 1991; 66
Donovan, Harwood, Drury, Diffley (CR51) 1997; 94
Vincent, Deplanque, Ceraline, Duclos, Bergerat (CR27) 1999; 91
Kaldis (CR9) 1999; 55
Bayart, Grigorieva, Leibovitch, Onclercq-Delic, Amor-Gueret (CR24) 2004; 64
Nishitani, Lygerou, Nishimoto, Nurse (CR53) 2000; 404
West, Blanco, Chan, Matos, Sarbajna, Wyatt (CR86) 2015; 80
Tanaka, Diffley (CR54) 2002; 4
Parker, Atherton-Fessler, Piwnica-Worms (CR10) 1992; 89
Norbury, Blow, Nurse (CR19) 1991; 10
Pagano, Pepperkok, Lukas, Baldin, Ansorge, Bartek (CR65) 1993; 121
Bonin, Reid, Tessarollo (CR119) 2001; 158
Jin, Gu, Morgan (CR42) 1996; 134
Poon, Chau, Yamashita, Hunter (CR23) 1997; 57
Tominaga, Li, Wang, Deng (CR39) 2006; 2
Janicke, Sprengart, Wati, Porter (CR85) 1998; 273
Harper, Adami, Wei, Keyomarsi, Elledge (CR95) 1993; 75
Nakajo, Yoshitome, Iwashita, Iida, Uto, Ueno (CR111) 2000; 14
Hanada, Budzowska, Davies, van Drunen, Onizawa, Beverloo (CR121) 2007; 14
Moyer, Lewis, Botchan (CR58) 2006; 103
Ajiro, Nishimoto, Takahashi (CR74) 1983; 258
Jiang, Pereira, Maxfield, Russell, Goudelock, Sanchez (CR82) 2003; 278
Chow, Poon (CR112) 2013; 32
Bell, Podetz-Pedersen, Aronovich, Belur, McIvor, Hackett (CR101) 2007; 2
Rass, Compton, Matos, Singleton, Ip, Blanco (CR105) 2010; 24
Sirbu, Couch, Feigerle, Bhaskara, Hiebert, Cortez (CR108) 2011; 25
Rappold, Iwabuchi, Date, Chen (CR80) 2001; 153
Anderson, Henderson, Adachi (CR79) 2001; 21
Minemoto, Uchida, Ohtsubo, Shimura, Sasagawa, Hirata (CR25) 2003; 412
Schuler, Dierich, Chambon, Metzger (CR118) 2004; 39
Vriend, De Witt Hamer, Van Noorden, Wurdinger (CR29) 2013; 1836
Sarbajna, Davies, West (CR87) 2014; 28
Aaltonen, Amini, Heikkila, Aittomaki, Tamminen, Nevanlinna (CR20) 2009; 100
Pfander, Matos (CR89) 2017; 591
Krek, Nigg (CR18) 1991; 10
Abbas, Keaton, Dutta (CR113) 2013; 5
Kelman, O’Donnell (CR60) 1995; 23
Heald, McKeon (CR75) 1990; 61
McIlwain, Berger, Mak (CR83) 2013; 5
Dimitrova, Chen, Spector, de Lange (CR77) 2008; 456
Garner, Kim, Lach, Kottemann, Smogorzewska (CR93) 2013; 5
Hirai, Iwasawa, Okada, Arai, Nishibata, Kobayashi (CR94) 2009; 8
Gautier, Solomon, Booher, Bazan, Kirschner (CR15) 1991; 67
Liu, Stanton, Wu, Piwnica-Worms (CR6) 1997; 17
Aarts, Sharpe, Garcia-Murillas, Gevensleben, Hurd, Shumway (CR110) 2012; 2
Diril, Ratnacaram, Padmakumar, Du, Wasser, Coppola (CR2) 2012; 109
Indra, Warot, Brocard, Bornert, Xiao, Chambon (CR46) 1999; 27
Strausfeld, Labbe, Fesquet, Cavadore, Picard, Sadhu (CR17) 1991; 351
Poon, Jiang, Toyoshima, Hunter (CR26) 1996; 271
Gupta, Trott, Porter (CR104) 2007; 282
R Heald (464_CR11) 1993; 74
GE Ward (464_CR76) 1990; 61
T Waldman (464_CR98) 1995; 55
L Monaco (464_CR72) 2005; 102
BM Sirbu (464_CR108) 2011; 25
LL Parker (464_CR10) 1992; 89
R Heald (464_CR75) 1990; 61
JL Bowers (464_CR55) 2004; 16
C Norbury (464_CR19) 1991; 10
F Fang (464_CR64) 1991; 66
LE Vriend (464_CR29) 2013; 1836
Z Kelman (464_CR60) 1995; 23
T Enoch (464_CR70) 1991; 112
W Krek (464_CR18) 1991; 10
A Kumagai (464_CR16) 1991; 64
JB Bell (464_CR101) 2007; 2
RY Poon (464_CR23) 1997; 57
P Jin (464_CR42) 1996; 134
S Hayashi (464_CR116) 2002; 244
LT Vassilev (464_CR48) 2006; 103
S Kornbluth (464_CR5) 1994; 5
MJ Solomon (464_CR8) 1992; 3
KE Ross (464_CR67) 2000; 11
SP Bell (464_CR49) 1992; 357
E Garner (464_CR93) 2013; 5
VC Padmakumar (464_CR100) 2009; 29
H Nishitani (464_CR53) 2000; 404
K Jiang (464_CR82) 2003; 278
K Lundgren (464_CR68) 1991; 64
TB Garcia (464_CR38) 2018; 64
JP Chow (464_CR30) 2003; 14
D Adhikari (464_CR45) 2016; 26
M Peter (464_CR71) 1990; 61
SC West (464_CR86) 2015; 80
A Bonin (464_CR119) 2001; 158
SE Moyer (464_CR58) 2006; 103
AJ Levine (464_CR99) 1997; 88
K Klotz-Noack (464_CR120) 2012; 125
I Rappold (464_CR80) 2001; 153
N Nakajo (464_CR111) 2000; 14
CH McGowan (464_CR12) 1993; 12
M Aarts (464_CR110) 2012; 2
RY Poon (464_CR26) 1996; 271
M Gupta (464_CR104) 2007; 282
Y Minemoto (464_CR25) 2003; 412
JT Yeeles (464_CR57) 2015; 519
C Postic (464_CR117) 2000; 26
M Pagano (464_CR66) 1992; 11
S Donovan (464_CR51) 1997; 94
K Coulonval (464_CR13) 2011; 22
LL Parker (464_CR7) 1992; 257
JP Chow (464_CR112) 2013; 32
T Abbas (464_CR113) 2013; 5
F Vincent (464_CR27) 1999; 91
LB Schultz (464_CR81) 2000; 151
J Gautier (464_CR15) 1991; 67
K Aaltonen (464_CR20) 2009; 100
Y Tominaga (464_CR39) 2006; 2
BT Hughes (464_CR106) 2013; 110
D Branzei (464_CR61) 2010; 11
M Schuler (464_CR118) 2004; 39
SX Pfister (464_CR37) 2015; 28
CJ Matheson (464_CR33) 2016; 37
AK Indra (464_CR46) 1999; 27
V Ho (464_CR102) 2015; 6
RU Janicke (464_CR85) 1998; 273
D Santamaria (464_CR1) 2007; 448
MK Diril (464_CR2) 2012; 109
DO Morgan (464_CR3) 1997; 13
N Johnson (464_CR28) 2009; 35
M Pagano (464_CR65) 1993; 121
K Ajiro (464_CR74) 1983; 258
Y Xiong (464_CR96) 1993; 366
U Strausfeld (464_CR17) 1991; 351
DR McIlwain (464_CR83) 2013; 5
H Kao (464_CR21) 2001; 194
R Dominguez-Kelly (464_CR41) 2011; 194
J Matos (464_CR90) 2011; 147
J Gautier (464_CR63) 1990; 60
L Wu (464_CR88) 2003; 426
K Hanada (464_CR121) 2007; 14
T Chen (464_CR32) 2012; 17
S Tanaka (464_CR54) 2002; 4
F Bunz (464_CR97) 1998; 282
N Dimitrova (464_CR77) 2008; 456
N Mailand (464_CR22) 2000; 288
H Zhao (464_CR107) 2012; 32
P Jin (464_CR43) 1998; 141
K Fukuda (464_CR59) 1995; 270
JR Pomerening (464_CR44) 2008; 19
A Blasina (464_CR103) 1997; 8
N Bucher (464_CR31) 2008; 98
H Beck (464_CR34) 2012; 32
MJ Lohka (464_CR62) 1998; 90
M Vooijs (464_CR115) 2001; 2
E Bayart (464_CR24) 2004; 64
R Moser (464_CR109) 2014; 20
F Liu (464_CR6) 1997; 17
M Woo (464_CR84) 1998; 12
U Rass (464_CR105) 2010; 24
M Krajewska (464_CR40) 2013; 32
L Anderson (464_CR79) 2001; 21
P Scaffidi (464_CR78) 2008; 10
P Kaldis (464_CR9) 1999; 55
D Maiorano (464_CR52) 2000; 404
B Pfander (464_CR89) 2017; 591
TR Coleman (464_CR50) 1996; 87
AM Heijink (464_CR35) 2015; 112
C Berthet (464_CR47) 2003; 13
S Tanaka (464_CR56) 2010; 119
H Hirai (464_CR94) 2009; 8
NJ Wells (464_CR14) 1999; 112
H Duda (464_CR91) 2016; 39
JW Harper (464_CR95) 1993; 75
PR Mueller (464_CR4) 1995; 270
JP Chow (464_CR36) 2003; 278
M Lewandoski (464_CR114) 1997; 62
D Gong (464_CR69) 2007; 17
BJ Wilkins (464_CR73) 2014; 343
HD Wyatt (464_CR92) 2013; 52
S Sarbajna (464_CR87) 2014; 28
References_xml – volume: 278
  start-page: 40815
  year: 2003
  end-page: 28
  ident: CR36
  article-title: Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints
  publication-title: J Biol Chem
  contributor:
    fullname: Poon
– volume: 32
  start-page: 4226
  year: 2012
  end-page: 36
  ident: CR34
  article-title: Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption
  publication-title: Mol Cell Biol
  contributor:
    fullname: Holmberg
– volume: 39
  start-page: 740
  year: 2016
  end-page: 55
  ident: CR91
  article-title: A mechanism for controlled breakage of under-replicated chromosomes during mitosis
  publication-title: Dev Cell
  contributor:
    fullname: Blanco
– volume: 13
  start-page: 261
  year: 1997
  end-page: 91
  ident: CR3
  article-title: Cyclin-dependent kinases: engines, clocks, and microprocessors
  publication-title: Annu Rev Cell Dev Biol
  contributor:
    fullname: Morgan
– volume: 32
  start-page: 4778
  year: 2013
  end-page: 88
  ident: CR112
  article-title: The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery
  publication-title: Oncogene
  contributor:
    fullname: Poon
– volume: 4
  start-page: 198
  year: 2002
  end-page: 207
  ident: CR54
  article-title: Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase
  publication-title: Nat Cell Biol
  contributor:
    fullname: Diffley
– volume: 278
  start-page: 25207
  year: 2003
  end-page: 17
  ident: CR82
  article-title: Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345
  publication-title: J Biol Chem
  contributor:
    fullname: Sanchez
– volume: 151
  start-page: 1381
  year: 2000
  end-page: 90
  ident: CR81
  article-title: p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks
  publication-title: J Cell Biol
  contributor:
    fullname: Halazonetis
– volume: 88
  start-page: 323
  year: 1997
  end-page: 31
  ident: CR99
  article-title: p53, the cellular gatekeeper for growth and division
  publication-title: Cell
  contributor:
    fullname: Levine
– volume: 244
  start-page: 305
  year: 2002
  end-page: 18
  ident: CR116
  article-title: Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse
  publication-title: Dev Biol
  contributor:
    fullname: McMahon
– volume: 11
  start-page: 1597
  year: 2000
  end-page: 609
  ident: CR67
  article-title: Activating phosphorylation of the Saccharomyces cerevisiae cyclin-dependent kinase, cdc28p, precedes cyclin binding
  publication-title: Mol Biol Cell
  contributor:
    fullname: Solomon
– volume: 28
  start-page: 557
  year: 2015
  end-page: 68
  ident: CR37
  article-title: Inhibiting WEE1 selectively kills histone H3K36me3-deficient cancers by dNTP starvation
  publication-title: Cancer Cell
  contributor:
    fullname: Orlando
– volume: 134
  start-page: 963
  year: 1996
  end-page: 70
  ident: CR42
  article-title: Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells
  publication-title: J Cell Biol
  contributor:
    fullname: Morgan
– volume: 10
  start-page: 452
  year: 2008
  end-page: 9
  ident: CR78
  article-title: Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
  publication-title: Nat Cell Biol
  contributor:
    fullname: Misteli
– volume: 61
  start-page: 591
  year: 1990
  end-page: 602
  ident: CR71
  article-title: In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase
  publication-title: Cell
  contributor:
    fullname: Nigg
– volume: 125
  start-page: 2436
  year: 2012
  end-page: 45
  ident: CR120
  article-title: Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation
  publication-title: J Cell Sci
  contributor:
    fullname: Blow
– volume: 16
  start-page: 967
  year: 2004
  end-page: 78
  ident: CR55
  article-title: ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication
  publication-title: Mol Cell
  contributor:
    fullname: Bell
– volume: 448
  start-page: 811
  year: 2007
  end-page: 5
  ident: CR1
  article-title: Cdk1 is sufficient to drive the mammalian cell cycle
  publication-title: Nature
  contributor:
    fullname: Newton
– volume: 112
  start-page: 15160
  year: 2015
  end-page: 5
  ident: CR35
  article-title: A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Kaldis
– volume: 100
  start-page: 1055
  year: 2009
  end-page: 60
  ident: CR20
  article-title: High cyclin B1 expression is associated with poor survival in breast cancer
  publication-title: Br J Cancer
  contributor:
    fullname: Nevanlinna
– volume: 273
  start-page: 9357
  year: 1998
  end-page: 60
  ident: CR85
  article-title: Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
  publication-title: J Biol Chem
  contributor:
    fullname: Porter
– volume: 270
  start-page: 22527
  year: 1995
  end-page: 34
  ident: CR59
  article-title: Structure-function relationship of the eukaryotic DNA replication factor, proliferating cell nuclear antigen
  publication-title: J Biol Chem
  contributor:
    fullname: Tsurimoto
– volume: 11
  start-page: 208
  year: 2010
  end-page: 19
  ident: CR61
  article-title: Maintaining genome stability at the replication fork
  publication-title: Nat Rev Mol Cell Biol
  contributor:
    fullname: Foiani
– volume: 87
  start-page: 53
  year: 1996
  end-page: 63
  ident: CR50
  article-title: The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts
  publication-title: Cell
  contributor:
    fullname: Dunphy
– volume: 26
  start-page: 1212
  year: 2016
  end-page: 25
  ident: CR45
  article-title: Inhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespan
  publication-title: Cell Res
  contributor:
    fullname: Bayazit
– volume: 412
  start-page: 13
  year: 2003
  end-page: 19
  ident: CR25
  article-title: Loss of p53 induces M-phase retardation following G2 DNA damage checkpoint abrogation
  publication-title: Arch Biochem Biophys
  contributor:
    fullname: Hirata
– volume: 64
  start-page: 30
  year: 2018
  end-page: 33
  ident: CR38
  article-title: Increased activity of both CDK1 and CDK2 is necessary for the combinatorial activity of WEE1 inhibition and cytarabine
  publication-title: Leuk Res
  contributor:
    fullname: Porter
– volume: 426
  start-page: 870
  year: 2003
  end-page: 4
  ident: CR88
  article-title: The Bloom’s syndrome helicase suppresses crossing over during homologous recombination
  publication-title: Nature
  contributor:
    fullname: Hickson
– volume: 17
  start-page: 85
  year: 2007
  end-page: 91
  ident: CR69
  article-title: Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1
  publication-title: Curr Biol
  contributor:
    fullname: Hahn
– volume: 5
  start-page: a012914
  year: 2013
  ident: CR113
  article-title: Genomic instability in cancer
  publication-title: Cold Spring Harb Perspect Biol
  contributor:
    fullname: Dutta
– volume: 24
  start-page: 1559
  year: 2010
  end-page: 69
  ident: CR105
  article-title: Mechanism of Holliday junction resolution by the human GEN1 protein
  publication-title: Genes Dev
  contributor:
    fullname: Blanco
– volume: 89
  start-page: 2917
  year: 1992
  end-page: 21
  ident: CR10
  article-title: p107 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Piwnica-Worms
– volume: 5
  start-page: 273
  year: 1994
  end-page: 82
  ident: CR5
  article-title: Membrane localization of the kinase which phosphorylates p34 on threonine 14
  publication-title: Mol Biol Cell
  contributor:
    fullname: Newport
– volume: 32
  start-page: 3001
  year: 2013
  end-page: 8
  ident: CR40
  article-title: Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination
  publication-title: Oncogene
  contributor:
    fullname: de Vries
– volume: 519
  start-page: 431
  year: 2015
  end-page: 5
  ident: CR57
  article-title: Regulated eukaryotic DNA replication origin firing with purified proteins
  publication-title: Nature
  contributor:
    fullname: Diffley
– volume: 26
  start-page: 149
  year: 2000
  end-page: 50
  ident: CR117
  article-title: DNA excision in liver by an albumin-Cre transgene occurs progressively with age
  publication-title: Genesis
  contributor:
    fullname: Magnuson
– volume: 35
  start-page: 327
  year: 2009
  end-page: 39
  ident: CR28
  article-title: Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage
  publication-title: Mol Cell
  contributor:
    fullname: Li
– volume: 141
  start-page: 875
  year: 1998
  end-page: 85
  ident: CR43
  article-title: Nuclear localization of cyclin B1 controls mitotic entry after DNA damage
  publication-title: J Cell Biol
  contributor:
    fullname: Morgan
– volume: 22
  start-page: 3971
  year: 2011
  end-page: 85
  ident: CR13
  article-title: Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation
  publication-title: Mol Biol Cell
  contributor:
    fullname: Roger
– volume: 55
  start-page: 5187
  year: 1995
  end-page: 90
  ident: CR98
  article-title: p21 is necessary for the p53-mediated G1 arrest in human cancer cells
  publication-title: Cancer Res
  contributor:
    fullname: Vogelstein
– volume: 98
  start-page: 523
  year: 2008
  end-page: 8
  ident: CR31
  article-title: G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer
  publication-title: Br J Cancer
  contributor:
    fullname: Britten
– volume: 147
  start-page: 158
  year: 2011
  end-page: 72
  ident: CR90
  article-title: Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis
  publication-title: Cell
  contributor:
    fullname: West
– volume: 456
  start-page: 524
  year: 2008
  end-page: 8
  ident: CR77
  article-title: 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
  publication-title: Nature
  contributor:
    fullname: de Lange
– volume: 61
  start-page: 561
  year: 1990
  end-page: 77
  ident: CR76
  article-title: Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C
  publication-title: Cell
  contributor:
    fullname: Kirschner
– volume: 2
  start-page: 292
  year: 2001
  end-page: 7
  ident: CR115
  article-title: A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent
  publication-title: EMBO Rep
  contributor:
    fullname: Berns
– volume: 90
  start-page: 591
  year: 1998
  end-page: 9
  ident: CR62
  article-title: Nuclear responses to MPF activation and inactivation in Xenopus oocytes and early embryos
  publication-title: Biol Cell
  contributor:
    fullname: Lohka
– volume: 55
  start-page: 284
  year: 1999
  end-page: 96
  ident: CR9
  article-title: The cdk-activating kinase (CAK): from yeast to mammals
  publication-title: Cell Mol Life Sci
  contributor:
    fullname: Kaldis
– volume: 404
  start-page: 622
  year: 2000
  end-page: 5
  ident: CR52
  article-title: XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
  publication-title: Nature
  contributor:
    fullname: Mechali
– volume: 64
  start-page: 903
  year: 1991
  end-page: 14
  ident: CR16
  article-title: The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system
  publication-title: Cell
  contributor:
    fullname: Dunphy
– volume: 119
  start-page: 565
  year: 2010
  end-page: 74
  ident: CR56
  article-title: Regulation of the initiation step of DNA replication by cyclin-dependent kinases
  publication-title: Chromosoma
  contributor:
    fullname: Araki
– volume: 11
  start-page: 961
  year: 1992
  end-page: 71
  ident: CR66
  article-title: Cyclin A is required at two points in the human cell cycle
  publication-title: EMBO J
  contributor:
    fullname: Draetta
– volume: 5
  start-page: a008656
  year: 2013
  ident: CR83
  article-title: Caspase functions in cell death and disease
  publication-title: Cold Spring Harb Perspect Biol
  contributor:
    fullname: Mak
– volume: 282
  start-page: 1497
  year: 1998
  end-page: 501
  ident: CR97
  article-title: Requirement for p53 and p21 to sustain G2 arrest after DNA damage
  publication-title: Science
  contributor:
    fullname: Brown
– volume: 62
  start-page: 159
  year: 1997
  end-page: 68
  ident: CR114
  article-title: Analysis of Fgf8 gene function in vertebrate development
  publication-title: Cold Spring Harb Symp Quant Biol
  contributor:
    fullname: Martin
– volume: 14
  start-page: 1096
  year: 2007
  end-page: 104
  ident: CR121
  article-title: The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks
  publication-title: Nat Struct Mol Biol
  contributor:
    fullname: Beverloo
– volume: 19
  start-page: 3426
  year: 2008
  end-page: 41
  ident: CR44
  article-title: Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF
  publication-title: Mol Biol Cell
  contributor:
    fullname: Ferrell
– volume: 103
  start-page: 10660
  year: 2006
  end-page: 5
  ident: CR48
  article-title: Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Sun
– volume: 351
  start-page: 242
  year: 1991
  end-page: 5
  ident: CR17
  article-title: Dephosphorylation and activation of a p34 /cyclin B complex in vitro by human CDC25 protein
  publication-title: Nature
  contributor:
    fullname: Sadhu
– volume: 3
  start-page: 13
  year: 1992
  end-page: 27
  ident: CR8
  article-title: Role of phosphorylation in p34cdc2 activation: identification of an activating kinase
  publication-title: Mol Biol Cell
  contributor:
    fullname: Kirschner
– volume: 27
  start-page: 4324
  year: 1999
  end-page: 7
  ident: CR46
  article-title: Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases
  publication-title: Nucl Acids Res
  contributor:
    fullname: Chambon
– volume: 14
  start-page: 328
  year: 2000
  end-page: 38
  ident: CR111
  article-title: Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes
  publication-title: Genes Dev
  contributor:
    fullname: Ueno
– volume: 17
  start-page: 571
  year: 1997
  end-page: 83
  ident: CR6
  article-title: The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex
  publication-title: Mol Cell Biol
  contributor:
    fullname: Piwnica-Worms
– volume: 5
  start-page: 207
  year: 2013
  end-page: 15
  ident: CR93
  article-title: Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions
  publication-title: Cell Rep
  contributor:
    fullname: Smogorzewska
– volume: 257
  start-page: 1955
  year: 1992
  end-page: 7
  ident: CR7
  article-title: Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase
  publication-title: Science
  contributor:
    fullname: Piwnica-Worms
– volume: 10
  start-page: 3331
  year: 1991
  end-page: 41
  ident: CR18
  article-title: Mutations of p34 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34 kinase activation in vertebrates
  publication-title: EMBO J
  contributor:
    fullname: Nigg
– volume: 8
  start-page: 2992
  year: 2009
  end-page: 3000
  ident: CR94
  article-title: Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
  publication-title: Mol Cancer Ther
  contributor:
    fullname: Kobayashi
– volume: 12
  start-page: 806
  year: 1998
  end-page: 19
  ident: CR84
  article-title: Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
  publication-title: Genes Dev
  contributor:
    fullname: Kagi
– volume: 74
  start-page: 463
  year: 1993
  end-page: 74
  ident: CR11
  article-title: Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
  publication-title: Cell
  contributor:
    fullname: McKeon
– volume: 288
  start-page: 1425
  year: 2000
  end-page: 9
  ident: CR22
  article-title: Rapid destruction of human Cdc25A in response to DNA damage
  publication-title: Science
  contributor:
    fullname: Bartek
– volume: 57
  start-page: 5168
  year: 1997
  end-page: 78
  ident: CR23
  article-title: The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells
  publication-title: Cancer Res
  contributor:
    fullname: Hunter
– volume: 91
  start-page: 665
  year: 1999
  end-page: 74
  ident: CR27
  article-title: p53-independent regulation of cyclin B1 in normal human fibroblasts during UV-induced G2-arrest
  publication-title: Biol Cell
  contributor:
    fullname: Bergerat
– volume: 121
  start-page: 101
  year: 1993
  end-page: 11
  ident: CR65
  article-title: Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts
  publication-title: J Cell Biol
  contributor:
    fullname: Bartek
– volume: 6
  start-page: 27252
  year: 2015
  end-page: 66
  ident: CR102
  article-title: TLR3 agonist and sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression
  publication-title: Oncotarget
  contributor:
    fullname: Tham
– volume: 110
  start-page: 8954
  year: 2013
  end-page: 9
  ident: CR106
  article-title: Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Clurman
– volume: 64
  start-page: 1111
  year: 1991
  end-page: 22
  ident: CR68
  article-title: mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2
  publication-title: Cell
  contributor:
    fullname: Beach
– volume: 37
  start-page: 872
  year: 2016
  end-page: 81
  ident: CR33
  article-title: Targeting WEE1 kinase in cancer
  publication-title: Trends Pharmacol Sci
  contributor:
    fullname: Reigan
– volume: 60
  start-page: 487
  year: 1990
  end-page: 94
  ident: CR63
  article-title: Cyclin is a component of maturation-promoting factor from Xenopus
  publication-title: Cell
  contributor:
    fullname: Maller
– volume: 17
  start-page: 194
  year: 2012
  end-page: 202
  ident: CR32
  article-title: Targeting the S and G2 checkpoint to treat cancer
  publication-title: Drug Discov Today
  contributor:
    fullname: Curtin
– volume: 1836
  start-page: 227
  year: 2013
  end-page: 35
  ident: CR29
  article-title: WEE1 inhibition and genomic instability in cancer
  publication-title: Biochim Biophys Acta
  contributor:
    fullname: Wurdinger
– volume: 66
  start-page: 731
  year: 1991
  end-page: 42
  ident: CR64
  article-title: Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes
  publication-title: Cell
  contributor:
    fullname: Newport
– volume: 153
  start-page: 613
  year: 2001
  end-page: 20
  ident: CR80
  article-title: Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways
  publication-title: J Cell Biol
  contributor:
    fullname: Chen
– volume: 8
  start-page: 1013
  year: 1997
  end-page: 23
  ident: CR103
  article-title: The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells
  publication-title: Mol Biol Cell
  contributor:
    fullname: McGowan
– volume: 28
  start-page: 1124
  year: 2014
  end-page: 36
  ident: CR87
  article-title: Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe
  publication-title: Genes Dev
  contributor:
    fullname: West
– volume: 102
  start-page: 14244
  year: 2005
  end-page: 8
  ident: CR72
  article-title: Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Sassone-Corsi
– volume: 80
  start-page: 103
  year: 2015
  end-page: 9
  ident: CR86
  article-title: Resolution of recombination intermediates: mechanisms and regulation
  publication-title: Cold Spring Harb Symp Quant Biol
  contributor:
    fullname: Wyatt
– volume: 94
  start-page: 5611
  year: 1997
  end-page: 6
  ident: CR51
  article-title: Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Diffley
– volume: 23
  start-page: 3613
  year: 1995
  end-page: 20
  ident: CR60
  article-title: Structural and functional similarities of prokaryotic and eukaryotic DNA polymerase sliding clamps
  publication-title: Nucl Acids Res
  contributor:
    fullname: O’Donnell
– volume: 67
  start-page: 197
  year: 1991
  end-page: 211
  ident: CR15
  article-title: cdc25 is a specific tyrosine phosphatase that directly activates p34
  publication-title: Cell
  contributor:
    fullname: Kirschner
– volume: 158
  start-page: 121
  year: 2001
  end-page: 34
  ident: CR119
  article-title: Isolation, microinjection, and transfer of mouse blastocysts
  publication-title: Methods Mol Biol
  contributor:
    fullname: Tessarollo
– volume: 282
  start-page: 4301
  year: 2007
  end-page: 9
  ident: CR104
  article-title: Rescue of a human cell line from endogenous Cdk1 depletion by Cdk1 lacking inhibitory phosphorylation sites
  publication-title: J Biol Chem
  contributor:
    fullname: Porter
– volume: 194
  start-page: 1313
  year: 2001
  end-page: 23
  ident: CR21
  article-title: Identification of cyclin B1 as a shared human epithelial tumor-associated antigen recognized by T cells
  publication-title: J Exp Med
  contributor:
    fullname: Whiteside
– volume: 10
  start-page: 3321
  year: 1991
  end-page: 9
  ident: CR19
  article-title: Regulatory phosphorylation of the p34 protein kinase in vertebrates
  publication-title: EMBO J
  contributor:
    fullname: Nurse
– volume: 14
  start-page: 3989
  year: 2003
  end-page: 4002
  ident: CR30
  article-title: DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase
  publication-title: Mol Biol Cell
  contributor:
    fullname: Arooz
– volume: 343
  start-page: 77
  year: 2014
  end-page: 80
  ident: CR73
  article-title: A cascade of histone modifications induces chromatin condensation in mitosis
  publication-title: Science
  contributor:
    fullname: Winkler
– volume: 32
  start-page: 1421
  year: 2012
  end-page: 32
  ident: CR107
  article-title: Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication
  publication-title: Mol Cell Biol
  contributor:
    fullname: Roberts
– volume: 25
  start-page: 1320
  year: 2011
  end-page: 7
  ident: CR108
  article-title: Analysis of protein dynamics at active, stalled, and collapsed replication forks
  publication-title: Genes Dev
  contributor:
    fullname: Cortez
– volume: 404
  start-page: 625
  year: 2000
  end-page: 8
  ident: CR53
  article-title: The Cdt1 protein is required to license DNA for replication in fission yeast
  publication-title: Nature
  contributor:
    fullname: Nurse
– volume: 75
  start-page: 805
  year: 1993
  end-page: 16
  ident: CR95
  article-title: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
  publication-title: Cell
  contributor:
    fullname: Elledge
– volume: 112
  start-page: 797
  year: 1991
  end-page: 807
  ident: CR70
  article-title: p34 acts as a lamin kinase in fission yeast
  publication-title: J Cell Biol
  contributor:
    fullname: Nigg
– volume: 21
  start-page: 1719
  year: 2001
  end-page: 29
  ident: CR79
  article-title: Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage
  publication-title: Mol Cell Biol
  contributor:
    fullname: Adachi
– volume: 29
  start-page: 2582
  year: 2009
  end-page: 93
  ident: CR100
  article-title: Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53
  publication-title: Mol Cell Biol
  contributor:
    fullname: Kaldis
– volume: 103
  start-page: 10236
  year: 2006
  end-page: 41
  ident: CR58
  article-title: Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Botchan
– volume: 2
  start-page: 3153
  year: 2007
  end-page: 65
  ident: CR101
  article-title: Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection
  publication-title: Nat Prot
  contributor:
    fullname: Hackett
– volume: 12
  start-page: 75
  year: 1993
  end-page: 85
  ident: CR12
  article-title: Human Wee1 kinase inhibits cell division by phosphorylating p34 exclusively on Tyr15
  publication-title: EMBO J
  contributor:
    fullname: Russell
– volume: 20
  start-page: 4274
  year: 2014
  end-page: 88
  ident: CR109
  article-title: Functional kinomics identifies candidate therapeutic targets in head and neck cancer
  publication-title: Clin Cancer Res
  contributor:
    fullname: Schaupp
– volume: 61
  start-page: 579
  year: 1990
  end-page: 89
  ident: CR75
  article-title: Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis
  publication-title: Cell
  contributor:
    fullname: McKeon
– volume: 112
  start-page: 3361
  issue: Pt 19
  year: 1999
  end-page: 71
  ident: CR14
  article-title: The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G2/M progression
  publication-title: J Cell Sci
  contributor:
    fullname: Hunter
– volume: 357
  start-page: 128
  year: 1992
  end-page: 34
  ident: CR49
  article-title: ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex
  publication-title: Nature
  contributor:
    fullname: Stillman
– volume: 194
  start-page: 567
  year: 2011
  end-page: 79
  ident: CR41
  article-title: Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease
  publication-title: J Cell Biol
  contributor:
    fullname: Medema
– volume: 591
  start-page: 2048
  year: 2017
  end-page: 56
  ident: CR89
  article-title: Control of Mus81 nuclease during the cell cycle
  publication-title: FEBS Lett
  contributor:
    fullname: Matos
– volume: 2
  start-page: 524
  year: 2012
  end-page: 39
  ident: CR110
  article-title: Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1
  publication-title: Cancer Discov
  contributor:
    fullname: Shumway
– volume: 2
  start-page: 161
  year: 2006
  end-page: 70
  ident: CR39
  article-title: Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development
  publication-title: Int J Biol Sci
  contributor:
    fullname: Deng
– volume: 271
  start-page: 13283
  year: 1996
  end-page: 91
  ident: CR26
  article-title: Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage
  publication-title: J Biol Chem
  contributor:
    fullname: Hunter
– volume: 52
  start-page: 234
  year: 2013
  end-page: 47
  ident: CR92
  article-title: Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells
  publication-title: Mol Cell
  contributor:
    fullname: West
– volume: 366
  start-page: 701
  year: 1993
  end-page: 4
  ident: CR96
  article-title: p21 is a universal inhibitor of cyclin kinases
  publication-title: Nature
  contributor:
    fullname: Beach
– volume: 270
  start-page: 86
  year: 1995
  end-page: 90
  ident: CR4
  article-title: Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15
  publication-title: Science
  contributor:
    fullname: Dunphy
– volume: 258
  start-page: 4534
  year: 1983
  end-page: 8
  ident: CR74
  article-title: Histone H1 and H3 phosphorylation during premature chromosome condensation in a temperature-sensitive mutant (tsBN2) of baby hamster kidney cells
  publication-title: J Biol Chem
  contributor:
    fullname: Takahashi
– volume: 13
  start-page: 1775
  year: 2003
  end-page: 85
  ident: CR47
  article-title: Cdk2 knockout mice are viable
  publication-title: Curr Biol
  contributor:
    fullname: Kaldis
– volume: 109
  start-page: 3826
  year: 2012
  end-page: 31
  ident: CR2
  article-title: Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Coppola
– volume: 64
  start-page: 8954
  year: 2004
  end-page: 9
  ident: CR24
  article-title: A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint
  publication-title: Cancer Res
  contributor:
    fullname: Amor-Gueret
– volume: 39
  start-page: 167
  year: 2004
  end-page: 72
  ident: CR118
  article-title: Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse
  publication-title: Genesis
  contributor:
    fullname: Metzger
– volume: 412
  start-page: 13
  year: 2003
  ident: 464_CR25
  publication-title: Arch Biochem Biophys
  doi: 10.1016/S0003-9861(03)00010-9
  contributor:
    fullname: Y Minemoto
– volume: 257
  start-page: 1955
  year: 1992
  ident: 464_CR7
  publication-title: Science
  doi: 10.1126/science.1384126
  contributor:
    fullname: LL Parker
– volume: 98
  start-page: 523
  year: 2008
  ident: 464_CR31
  publication-title: Br J Cancer
  doi: 10.1038/sj.bjc.6604208
  contributor:
    fullname: N Bucher
– volume: 27
  start-page: 4324
  year: 1999
  ident: 464_CR46
  publication-title: Nucl Acids Res
  doi: 10.1093/nar/27.22.4324
  contributor:
    fullname: AK Indra
– volume: 55
  start-page: 5187
  year: 1995
  ident: 464_CR98
  publication-title: Cancer Res
  contributor:
    fullname: T Waldman
– volume: 591
  start-page: 2048
  year: 2017
  ident: 464_CR89
  publication-title: FEBS Lett
  doi: 10.1002/1873-3468.12727
  contributor:
    fullname: B Pfander
– volume: 6
  start-page: 27252
  year: 2015
  ident: 464_CR102
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.4583
  contributor:
    fullname: V Ho
– volume: 103
  start-page: 10660
  year: 2006
  ident: 464_CR48
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0600447103
  contributor:
    fullname: LT Vassilev
– volume: 1836
  start-page: 227
  year: 2013
  ident: 464_CR29
  publication-title: Biochim Biophys Acta
  contributor:
    fullname: LE Vriend
– volume: 14
  start-page: 3989
  year: 2003
  ident: 464_CR30
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.e03-03-0168
  contributor:
    fullname: JP Chow
– volume: 28
  start-page: 557
  year: 2015
  ident: 464_CR37
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2015.09.015
  contributor:
    fullname: SX Pfister
– volume: 64
  start-page: 8954
  year: 2004
  ident: 464_CR24
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-04-1613
  contributor:
    fullname: E Bayart
– volume: 29
  start-page: 2582
  year: 2009
  ident: 464_CR100
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00952-08
  contributor:
    fullname: VC Padmakumar
– volume: 270
  start-page: 22527
  year: 1995
  ident: 464_CR59
  publication-title: J Biol Chem
  doi: 10.1074/jbc.270.38.22527
  contributor:
    fullname: K Fukuda
– volume: 32
  start-page: 4778
  year: 2013
  ident: 464_CR112
  publication-title: Oncogene
  doi: 10.1038/onc.2012.504
  contributor:
    fullname: JP Chow
– volume: 110
  start-page: 8954
  year: 2013
  ident: 464_CR106
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1302927110
  contributor:
    fullname: BT Hughes
– volume: 153
  start-page: 613
  year: 2001
  ident: 464_CR80
  publication-title: J Cell Biol
  doi: 10.1083/jcb.153.3.613
  contributor:
    fullname: I Rappold
– volume: 2
  start-page: 292
  year: 2001
  ident: 464_CR115
  publication-title: EMBO Rep
  doi: 10.1093/embo-reports/kve064
  contributor:
    fullname: M Vooijs
– volume: 158
  start-page: 121
  year: 2001
  ident: 464_CR119
  publication-title: Methods Mol Biol
  contributor:
    fullname: A Bonin
– volume: 32
  start-page: 1421
  year: 2012
  ident: 464_CR107
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.06721-11
  contributor:
    fullname: H Zhao
– volume: 32
  start-page: 3001
  year: 2013
  ident: 464_CR40
  publication-title: Oncogene
  doi: 10.1038/onc.2012.296
  contributor:
    fullname: M Krajewska
– volume: 448
  start-page: 811
  year: 2007
  ident: 464_CR1
  publication-title: Nature
  doi: 10.1038/nature06046
  contributor:
    fullname: D Santamaria
– volume: 121
  start-page: 101
  year: 1993
  ident: 464_CR65
  publication-title: J Cell Biol
  doi: 10.1083/jcb.121.1.101
  contributor:
    fullname: M Pagano
– volume: 25
  start-page: 1320
  year: 2011
  ident: 464_CR108
  publication-title: Genes Dev
  doi: 10.1101/gad.2053211
  contributor:
    fullname: BM Sirbu
– volume: 26
  start-page: 149
  year: 2000
  ident: 464_CR117
  publication-title: Genesis
  doi: 10.1002/(SICI)1526-968X(200002)26:2<149::AID-GENE16>3.0.CO;2-V
  contributor:
    fullname: C Postic
– volume: 11
  start-page: 1597
  year: 2000
  ident: 464_CR67
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.11.5.1597
  contributor:
    fullname: KE Ross
– volume: 2
  start-page: 161
  year: 2006
  ident: 464_CR39
  publication-title: Int J Biol Sci
  doi: 10.7150/ijbs.2.161
  contributor:
    fullname: Y Tominaga
– volume: 271
  start-page: 13283
  year: 1996
  ident: 464_CR26
  publication-title: J Biol Chem
  doi: 10.1074/jbc.271.22.13283
  contributor:
    fullname: RY Poon
– volume: 366
  start-page: 701
  year: 1993
  ident: 464_CR96
  publication-title: Nature
  doi: 10.1038/366701a0
  contributor:
    fullname: Y Xiong
– volume: 343
  start-page: 77
  year: 2014
  ident: 464_CR73
  publication-title: Science
  doi: 10.1126/science.1244508
  contributor:
    fullname: BJ Wilkins
– volume: 17
  start-page: 85
  year: 2007
  ident: 464_CR69
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2006.11.066
  contributor:
    fullname: D Gong
– volume: 10
  start-page: 452
  year: 2008
  ident: 464_CR78
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb1708
  contributor:
    fullname: P Scaffidi
– volume: 24
  start-page: 1559
  year: 2010
  ident: 464_CR105
  publication-title: Genes Dev
  doi: 10.1101/gad.585310
  contributor:
    fullname: U Rass
– volume: 26
  start-page: 1212
  year: 2016
  ident: 464_CR45
  publication-title: Cell Res
  doi: 10.1038/cr.2016.119
  contributor:
    fullname: D Adhikari
– volume: 10
  start-page: 3331
  year: 1991
  ident: 464_CR18
  publication-title: EMBO J
  doi: 10.1002/j.1460-2075.1991.tb04897.x
  contributor:
    fullname: W Krek
– volume: 5
  start-page: a012914
  year: 2013
  ident: 464_CR113
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/cshperspect.a012914
  contributor:
    fullname: T Abbas
– volume: 112
  start-page: 15160
  year: 2015
  ident: 464_CR35
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1505283112
  contributor:
    fullname: AM Heijink
– volume: 8
  start-page: 2992
  year: 2009
  ident: 464_CR94
  publication-title: Mol Cancer Ther
  doi: 10.1158/1535-7163.MCT-09-0463
  contributor:
    fullname: H Hirai
– volume: 12
  start-page: 806
  year: 1998
  ident: 464_CR84
  publication-title: Genes Dev
  doi: 10.1101/gad.12.6.806
  contributor:
    fullname: M Woo
– volume: 288
  start-page: 1425
  year: 2000
  ident: 464_CR22
  publication-title: Science
  doi: 10.1126/science.288.5470.1425
  contributor:
    fullname: N Mailand
– volume: 13
  start-page: 261
  year: 1997
  ident: 464_CR3
  publication-title: Annu Rev Cell Dev Biol
  doi: 10.1146/annurev.cellbio.13.1.261
  contributor:
    fullname: DO Morgan
– volume: 194
  start-page: 1313
  year: 2001
  ident: 464_CR21
  publication-title: J Exp Med
  doi: 10.1084/jem.194.9.1313
  contributor:
    fullname: H Kao
– volume: 61
  start-page: 579
  year: 1990
  ident: 464_CR75
  publication-title: Cell
  doi: 10.1016/0092-8674(90)90470-Y
  contributor:
    fullname: R Heald
– volume: 20
  start-page: 4274
  year: 2014
  ident: 464_CR109
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-13-2858
  contributor:
    fullname: R Moser
– volume: 35
  start-page: 327
  year: 2009
  ident: 464_CR28
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2009.06.036
  contributor:
    fullname: N Johnson
– volume: 28
  start-page: 1124
  year: 2014
  ident: 464_CR87
  publication-title: Genes Dev
  doi: 10.1101/gad.238303.114
  contributor:
    fullname: S Sarbajna
– volume: 37
  start-page: 872
  year: 2016
  ident: 464_CR33
  publication-title: Trends Pharmacol Sci
  doi: 10.1016/j.tips.2016.06.006
  contributor:
    fullname: CJ Matheson
– volume: 151
  start-page: 1381
  year: 2000
  ident: 464_CR81
  publication-title: J Cell Biol
  doi: 10.1083/jcb.151.7.1381
  contributor:
    fullname: LB Schultz
– volume: 426
  start-page: 870
  year: 2003
  ident: 464_CR88
  publication-title: Nature
  doi: 10.1038/nature02253
  contributor:
    fullname: L Wu
– volume: 19
  start-page: 3426
  year: 2008
  ident: 464_CR44
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.e08-02-0172
  contributor:
    fullname: JR Pomerening
– volume: 12
  start-page: 75
  year: 1993
  ident: 464_CR12
  publication-title: EMBO J
  doi: 10.1002/j.1460-2075.1993.tb05633.x
  contributor:
    fullname: CH McGowan
– volume: 102
  start-page: 14244
  year: 2005
  ident: 464_CR72
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0506252102
  contributor:
    fullname: L Monaco
– volume: 89
  start-page: 2917
  year: 1992
  ident: 464_CR10
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.89.7.2917
  contributor:
    fullname: LL Parker
– volume: 282
  start-page: 1497
  year: 1998
  ident: 464_CR97
  publication-title: Science
  doi: 10.1126/science.282.5393.1497
  contributor:
    fullname: F Bunz
– volume: 55
  start-page: 284
  year: 1999
  ident: 464_CR9
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s000180050290
  contributor:
    fullname: P Kaldis
– volume: 456
  start-page: 524
  year: 2008
  ident: 464_CR77
  publication-title: Nature
  doi: 10.1038/nature07433
  contributor:
    fullname: N Dimitrova
– volume: 61
  start-page: 561
  year: 1990
  ident: 464_CR76
  publication-title: Cell
  doi: 10.1016/0092-8674(90)90469-U
  contributor:
    fullname: GE Ward
– volume: 64
  start-page: 903
  year: 1991
  ident: 464_CR16
  publication-title: Cell
  doi: 10.1016/0092-8674(91)90315-P
  contributor:
    fullname: A Kumagai
– volume: 14
  start-page: 1096
  year: 2007
  ident: 464_CR121
  publication-title: Nat Struct Mol Biol
  doi: 10.1038/nsmb1313
  contributor:
    fullname: K Hanada
– volume: 270
  start-page: 86
  year: 1995
  ident: 464_CR4
  publication-title: Science
  doi: 10.1126/science.270.5233.86
  contributor:
    fullname: PR Mueller
– volume: 147
  start-page: 158
  year: 2011
  ident: 464_CR90
  publication-title: Cell
  doi: 10.1016/j.cell.2011.08.032
  contributor:
    fullname: J Matos
– volume: 16
  start-page: 967
  year: 2004
  ident: 464_CR55
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2004.11.038
  contributor:
    fullname: JL Bowers
– volume: 14
  start-page: 328
  year: 2000
  ident: 464_CR111
  publication-title: Genes Dev
  doi: 10.1101/gad.14.3.328
  contributor:
    fullname: N Nakajo
– volume: 278
  start-page: 40815
  year: 2003
  ident: 464_CR36
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M306683200
  contributor:
    fullname: JP Chow
– volume: 357
  start-page: 128
  year: 1992
  ident: 464_CR49
  publication-title: Nature
  doi: 10.1038/357128a0
  contributor:
    fullname: SP Bell
– volume: 11
  start-page: 961
  year: 1992
  ident: 464_CR66
  publication-title: EMBO J
  doi: 10.1002/j.1460-2075.1992.tb05135.x
  contributor:
    fullname: M Pagano
– volume: 91
  start-page: 665
  year: 1999
  ident: 464_CR27
  publication-title: Biol Cell
  doi: 10.1111/j.1768-322X.1999.tb01111.x
  contributor:
    fullname: F Vincent
– volume: 2
  start-page: 524
  year: 2012
  ident: 464_CR110
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-11-0320
  contributor:
    fullname: M Aarts
– volume: 74
  start-page: 463
  year: 1993
  ident: 464_CR11
  publication-title: Cell
  doi: 10.1016/0092-8674(93)80048-J
  contributor:
    fullname: R Heald
– volume: 57
  start-page: 5168
  year: 1997
  ident: 464_CR23
  publication-title: Cancer Res
  contributor:
    fullname: RY Poon
– volume: 258
  start-page: 4534
  year: 1983
  ident: 464_CR74
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)32656-5
  contributor:
    fullname: K Ajiro
– volume: 88
  start-page: 323
  year: 1997
  ident: 464_CR99
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81871-1
  contributor:
    fullname: AJ Levine
– volume: 39
  start-page: 740
  year: 2016
  ident: 464_CR91
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2016.11.017
  contributor:
    fullname: H Duda
– volume: 17
  start-page: 571
  year: 1997
  ident: 464_CR6
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.17.2.571
  contributor:
    fullname: F Liu
– volume: 5
  start-page: a008656
  year: 2013
  ident: 464_CR83
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/cshperspect.a008656
  contributor:
    fullname: DR McIlwain
– volume: 90
  start-page: 591
  year: 1998
  ident: 464_CR62
  publication-title: Biol Cell
  doi: 10.1111/j.1768-322X.1998.tb01068.x
  contributor:
    fullname: MJ Lohka
– volume: 244
  start-page: 305
  year: 2002
  ident: 464_CR116
  publication-title: Dev Biol
  doi: 10.1006/dbio.2002.0597
  contributor:
    fullname: S Hayashi
– volume: 10
  start-page: 3321
  year: 1991
  ident: 464_CR19
  publication-title: EMBO J
  doi: 10.1002/j.1460-2075.1991.tb04896.x
  contributor:
    fullname: C Norbury
– volume: 22
  start-page: 3971
  year: 2011
  ident: 464_CR13
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.e11-02-0136
  contributor:
    fullname: K Coulonval
– volume: 119
  start-page: 565
  year: 2010
  ident: 464_CR56
  publication-title: Chromosoma
  doi: 10.1007/s00412-010-0291-8
  contributor:
    fullname: S Tanaka
– volume: 194
  start-page: 567
  year: 2011
  ident: 464_CR41
  publication-title: J Cell Biol
  doi: 10.1083/jcb.201101047
  contributor:
    fullname: R Dominguez-Kelly
– volume: 80
  start-page: 103
  year: 2015
  ident: 464_CR86
  publication-title: Cold Spring Harb Symp Quant Biol
  doi: 10.1101/sqb.2015.80.027649
  contributor:
    fullname: SC West
– volume: 64
  start-page: 1111
  year: 1991
  ident: 464_CR68
  publication-title: Cell
  doi: 10.1016/0092-8674(91)90266-2
  contributor:
    fullname: K Lundgren
– volume: 17
  start-page: 194
  year: 2012
  ident: 464_CR32
  publication-title: Drug Discov Today
  doi: 10.1016/j.drudis.2011.12.009
  contributor:
    fullname: T Chen
– volume: 404
  start-page: 622
  year: 2000
  ident: 464_CR52
  publication-title: Nature
  doi: 10.1038/35007104
  contributor:
    fullname: D Maiorano
– volume: 23
  start-page: 3613
  year: 1995
  ident: 464_CR60
  publication-title: Nucl Acids Res
  doi: 10.1093/nar/23.18.3613
  contributor:
    fullname: Z Kelman
– volume: 32
  start-page: 4226
  year: 2012
  ident: 464_CR34
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.00412-12
  contributor:
    fullname: H Beck
– volume: 112
  start-page: 797
  year: 1991
  ident: 464_CR70
  publication-title: J Cell Biol
  doi: 10.1083/jcb.112.5.797
  contributor:
    fullname: T Enoch
– volume: 125
  start-page: 2436
  year: 2012
  ident: 464_CR120
  publication-title: J Cell Sci
  doi: 10.1242/jcs.100883
  contributor:
    fullname: K Klotz-Noack
– volume: 60
  start-page: 487
  year: 1990
  ident: 464_CR63
  publication-title: Cell
  doi: 10.1016/0092-8674(90)90599-A
  contributor:
    fullname: J Gautier
– volume: 3
  start-page: 13
  year: 1992
  ident: 464_CR8
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.3.1.13
  contributor:
    fullname: MJ Solomon
– volume: 278
  start-page: 25207
  year: 2003
  ident: 464_CR82
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M300070200
  contributor:
    fullname: K Jiang
– volume: 52
  start-page: 234
  year: 2013
  ident: 464_CR92
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2013.08.035
  contributor:
    fullname: HD Wyatt
– volume: 39
  start-page: 167
  year: 2004
  ident: 464_CR118
  publication-title: Genesis
  doi: 10.1002/gene.20039
  contributor:
    fullname: M Schuler
– volume: 100
  start-page: 1055
  year: 2009
  ident: 464_CR20
  publication-title: Br J Cancer
  doi: 10.1038/sj.bjc.6604874
  contributor:
    fullname: K Aaltonen
– volume: 13
  start-page: 1775
  year: 2003
  ident: 464_CR47
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2003.09.024
  contributor:
    fullname: C Berthet
– volume: 4
  start-page: 198
  year: 2002
  ident: 464_CR54
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb757
  contributor:
    fullname: S Tanaka
– volume: 2
  start-page: 3153
  year: 2007
  ident: 464_CR101
  publication-title: Nat Prot
  doi: 10.1038/nprot.2007.471
  contributor:
    fullname: JB Bell
– volume: 103
  start-page: 10236
  year: 2006
  ident: 464_CR58
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0602400103
  contributor:
    fullname: SE Moyer
– volume: 11
  start-page: 208
  year: 2010
  ident: 464_CR61
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm2852
  contributor:
    fullname: D Branzei
– volume: 67
  start-page: 197
  year: 1991
  ident: 464_CR15
  publication-title: Cell
  doi: 10.1016/0092-8674(91)90583-K
  contributor:
    fullname: J Gautier
– volume: 112
  start-page: 3361
  issue: Pt 19
  year: 1999
  ident: 464_CR14
  publication-title: J Cell Sci
  doi: 10.1242/jcs.112.19.3361
  contributor:
    fullname: NJ Wells
– volume: 87
  start-page: 53
  year: 1996
  ident: 464_CR50
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81322-7
  contributor:
    fullname: TR Coleman
– volume: 61
  start-page: 591
  year: 1990
  ident: 464_CR71
  publication-title: Cell
  doi: 10.1016/0092-8674(90)90471-P
  contributor:
    fullname: M Peter
– volume: 519
  start-page: 431
  year: 2015
  ident: 464_CR57
  publication-title: Nature
  doi: 10.1038/nature14285
  contributor:
    fullname: JT Yeeles
– volume: 8
  start-page: 1013
  year: 1997
  ident: 464_CR103
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.8.6.1013
  contributor:
    fullname: A Blasina
– volume: 64
  start-page: 30
  year: 2018
  ident: 464_CR38
  publication-title: Leuk Res
  doi: 10.1016/j.leukres.2017.11.004
  contributor:
    fullname: TB Garcia
– volume: 5
  start-page: 273
  year: 1994
  ident: 464_CR5
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.5.3.273
  contributor:
    fullname: S Kornbluth
– volume: 404
  start-page: 625
  year: 2000
  ident: 464_CR53
  publication-title: Nature
  doi: 10.1038/35007110
  contributor:
    fullname: H Nishitani
– volume: 282
  start-page: 4301
  year: 2007
  ident: 464_CR104
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M607910200
  contributor:
    fullname: M Gupta
– volume: 62
  start-page: 159
  year: 1997
  ident: 464_CR114
  publication-title: Cold Spring Harb Symp Quant Biol
  doi: 10.1101/SQB.1997.062.01.021
  contributor:
    fullname: M Lewandoski
– volume: 109
  start-page: 3826
  year: 2012
  ident: 464_CR2
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1115201109
  contributor:
    fullname: MK Diril
– volume: 66
  start-page: 731
  year: 1991
  ident: 464_CR64
  publication-title: Cell
  doi: 10.1016/0092-8674(91)90117-H
  contributor:
    fullname: F Fang
– volume: 5
  start-page: 207
  year: 2013
  ident: 464_CR93
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2013.08.041
  contributor:
    fullname: E Garner
– volume: 75
  start-page: 805
  year: 1993
  ident: 464_CR95
  publication-title: Cell
  doi: 10.1016/0092-8674(93)90499-G
  contributor:
    fullname: JW Harper
– volume: 351
  start-page: 242
  year: 1991
  ident: 464_CR17
  publication-title: Nature
  doi: 10.1038/351242a0
  contributor:
    fullname: U Strausfeld
– volume: 21
  start-page: 1719
  year: 2001
  ident: 464_CR79
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.21.5.1719-1729.2001
  contributor:
    fullname: L Anderson
– volume: 94
  start-page: 5611
  year: 1997
  ident: 464_CR51
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.94.11.5611
  contributor:
    fullname: S Donovan
– volume: 141
  start-page: 875
  year: 1998
  ident: 464_CR43
  publication-title: J Cell Biol
  doi: 10.1083/jcb.141.4.875
  contributor:
    fullname: P Jin
– volume: 273
  start-page: 9357
  year: 1998
  ident: 464_CR85
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.16.9357
  contributor:
    fullname: RU Janicke
– volume: 134
  start-page: 963
  year: 1996
  ident: 464_CR42
  publication-title: J Cell Biol
  doi: 10.1083/jcb.134.4.963
  contributor:
    fullname: P Jin
SSID ssj0007902
Score 2.5397198
Snippet Cell cycle regulation, especially faithful DNA replication and mitosis, are crucial to maintain genome stability. Cyclin-dependent kinase (CDK)/cyclin...
SourceID pubmedcentral
proquest
gale
crossref
pubmed
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 998
SubjectTerms 13/1
13/106
13/31
13/89
42/41
631/67/70
631/80/641/1655
64/60
96/95
Amino Acid Substitution
Animals
Antineoplastic agents
Apoptosis
Cancer
Cancer treatment
Carcinogenesis
CDC2 Protein Kinase - genetics
CDC2 Protein Kinase - metabolism
Cell Biology
Cell cycle
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cell proliferation
Cellular signal transduction
Clinical trials
Cyclin-dependent kinase 2
Cyclin-dependent kinases
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA damage
DNA replication
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Embryo fibroblasts
Embryo Loss - enzymology
Embryo Loss - genetics
Embryo Loss - pathology
Embryo, Mammalian - enzymology
Embryo, Mammalian - pathology
Embryos
Endonuclease
Enzyme Activation
Genetic aspects
Genomes
Genomics
Health aspects
Human Genetics
Intelligence gathering
Internal Medicine
Kinases
Lethality
Liver
Medicine
Medicine & Public Health
Mice
Mice, Transgenic
Mitosis
Mutation, Missense
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Nucleases
Oncology
p53 Protein
Phosphorylation
Phosphotransferases
Protein-Tyrosine Kinases - genetics
Protein-Tyrosine Kinases - metabolism
S Phase
Transcription Factors - genetics
Transcription Factors - metabolism
Tumor proteins
Tumors
SummonAdditionalLinks – databaseName: Public Health Database
  dbid: 8C1
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Za9wwEB7ahB4vIdlebtKiQKHQYmJLPrRPJSwNoZASSEPzJmQdbEhjb9feh_z7zvjYrRfaZ8m2rJFmPmm-mQH4kMnCWsNtaDjPw8TENpSamDlSR7HLY54VFCh88T07v06-3aQ3_YVb3dMqB53YKmpbGbojP-GUaIqyk0-_LH6HVDWKvKt9CY3HsBuToaNI8dmG4pF3nENEEVGIQIYPXk0hT2pU3pJoXJLIjUkYjezStnb-yzxtUye3_KetWTrbh70eT7LTbgEcwCNXTuBJV2HyYQLPZkNBtwk8vej96C_g5-WScrWulo5RYEN3Lcsqz2b2Lma_UO41ayp2j9sd38vaLE81uy3ZFVvM0e4xXVrm7ovlA2XWxQeaeYvnX8L12dcfs_OwL7EQmlTkDepCnlo8BaPGFjbWVhfCIkAxUjtbeBlZkWrs4RD3aO6d95kQXtLdqc20zrV4BTtlVbo3wNDIeeNkkgg-TfLCTT2evXjseUGuQJ4F8GmYYLXoMmmo1gMupOqkoVAaiqShogA-kggU7TKcZ6P7YAH8FOWrUqdpTrwAPN8FcDTqiXNqxs2DEFW_O2u1WUsBHK-b6UlinJWuWlEfcsqTjQ_gdSfz9bAFBeCnCf5SPloN6w6Us3vcUt7O29zdeD4jTBnA52HdbIb1z9l4-_-fOITnCOOmHZf8CHaa5cq9Q6jUFO_b_fAHdqQOkQ
  priority: 102
  providerName: ProQuest
Title Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality
URI https://link.springer.com/article/10.1038/s41388-018-0464-0
https://www.ncbi.nlm.nih.gov/pubmed/30190546
https://www.proquest.com/docview/2180982299
https://search.proquest.com/docview/2101273413
https://pubmed.ncbi.nlm.nih.gov/PMC6756125
Volume 38
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3dT9swED9tILa9INZ9ZUBlJKRJmyIaO4ndR4hAaBIIjaH1zXJiW0UbKWrTB_773eWjWyp44KUvvqSJz777Xe7uZ4DDVOXWFtyGBecyjIvIhspQZY4yo8jJiKc5NQpfXKbnN_H3STJpyaKpF6aXvxfqaIFGVlG5laIixDjE6HwTXbCkxZyl2croyqa8EAHDKETMwrsE5mO36LmgdUP8nydar5JcS5XWHuhsB7Zb6MiOG12_hReuHMBWc5jkwwBeZ93ZbQN4ddGmzN_Br6s50bIu545RD0PzBZbNPMvs74j9QRUvWDVjd7iz8b6sJnRasNuSXbP7Kbo4ZkrL3F0-fyASXbygmtbQ_T3cnJ3-zM7D9jSFsEiErNDs8cRiwIvGWdjIWJMLi1ikUMbZ3KuRFYlBCYcQx3DvvE-F8Io-k9rUGGnEB9goZ6X7BAz9mS-cimPBx7HM3dhjmMUjz3PK-vE0gK_dBOv7hjRD18luoXSjDY3a0KQNPQrgC6lA04bCeS5M2xeAf0XUVPo4kVQCgKFcAHs9SZzToj_cKVG3G3GhOfGTEan9OICD1TBdScVlpZstSYby7-TOA_jY6Hz12IJ67ZMYX0n2VsNKgOi5-yPl7bSm6cZQjOBjAN-6dfPvsZ6cjc_Pkt6FNwjgxk0V-R5sVPOl20eQVOVDeCknEn9VFg1h8-T08urHsN4yfwFDkQqH
link.rule.ids 230,314,780,784,885,12056,12223,21388,27924,27925,31719,31720,33266,33267,33744,33745,41120,42189,43310,43579,43805,51576,73745,74014,74302
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED9BJxgvE5SPBQYYCQkJFC2x8-E-TVu1qcBaTbCJvVlO7KgTLOma9GH_PXf56JZK8GynTXz23c--n38H8DGSiTEpN27KeewGqW9cqYmZI7Xn29jnUUIXhaezaHIRfLsML9sDt7KlVXY-sXbUpkjpjHyfk9AUqZOPDhY3LlWNouxqW0LjIWyRcno4gK2j49nZj7UvjhvWIeIIz0Uow7u8ppD7JbpvSUQuSfTGwPV6kWnTP98LUJvkyY0Mah2YTp7CToso2WEzBZ7BA5sP4VFTY_J2CNvjrqTbEB5P20z6c_h1tiS11tXSMrra0BzMsiJjY_PbZ3_Q8iWrCnaNCx5_l9U6TyW7ytlPtphj5GM6N8xeJ8tb0tbFB6p5jehfwMXJ8fl44rZFFtw0FHGF3pCHBvfB6LOF8bXRiTAIUVKprUky6RkRauxhEflontksi4TIJJ2emkjrWIuXMMiL3O4CwzCXpVYGgeCjIE7sKMPdF_cznlAykEcOfO4GWC0aLQ1V58CFVI01FFpDkTWU58AnMoGidYbjnOr2ugD-FSlWqcMwJmYA7vAc2Ov1xDFN-82dEVW7Pkt1N5sc-LBupieJc5bbYkV9KC1PUd6BV43N168t6Ap-GOAnxb3ZsO5Aqt39lvxqXqt34w6NUKUDX7p5c_da_xyN1___iPewPTmfnqrTr7Pvb-AJgrpRwyzfg0G1XNm3CJyq5F27Ov4CVykTHw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED9BJwYvCAqDwAAjISGBoiZ2PtwnNMqq8bGqAib2Zjmxo06wpDTpw_577hKno5Xg2U6b-L5-9v18B_AqkZkxOTd-znnqR3lofKmJmSN1ENo05ElGF4VPZ8nJWfTpPD53_Kfa0Sp7n9g6alPldEY-4lRoiqqTj0eFo0XMP0zfLX_71EGKMq2uncZN2MOoGPAB7L0_ns2_bvxy2jEQEVMEPsIa3uc4hRzV6MolkbokUR0jP9iKUru--q9gtUuk3MmmtkFqeg_uOnTJjjp1uA83bDmEW12_yash3J707d2GsH_qsuoP4Md8RZVb1yvL6JpDd0jLqoJNzM-Q_UItqFlTsUs0fvxd1tZ8qtlFyb6x5QKjINOlYfYyW11RnV18oFm06P4hnE2Pv09OfNdwwc9jkTboGXlscE-M_luYUBudCYNwJZfamqyQgRGxxhkWUZDmhS2KRIhC0kmqSbROtTiAQVmV9jEwDHlFbmUUCT6O0syOC9yJ8bDgGSUGeeLBm36B1bKrq6HafLiQqpOGQmkokoYKPHhNIlBkc7jOuXZXB_CvqHqVOopTYgngbs-Dw62ZuKb59nAvROVstVbXmuXBy80wPUn8s9JWa5pDKXqK-B486mS-eW1B1_HjCD8p3dKGzQSq4L09Ul4s2kreuFsjhOnB215vrl_rn6vx5P8f8QL20TDUl4-zz0_hDuK7cUcyP4RBs1rbZ4ihmuy5M44_aCgXTA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Premature+activation+of+Cdk1+leads+to+mitotic+events+in+S+phase+and+embryonic+lethality&rft.jtitle=Oncogene&rft.au=Szmyd%2C+Radoslaw&rft.au=Niska-Blakie%2C+Joanna&rft.au=Diril%2C+M.+Kasim&rft.au=Renck+Nunes%2C+Patr%C3%ADcia&rft.date=2019-02-01&rft.pub=Nature+Publishing+Group&rft.issn=0950-9232&rft.volume=38&rft.issue=7&rft.spage=998&rft_id=info:doi/10.1038%2Fs41388-018-0464-0&rft.externalDocID=A574208014
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0950-9232&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0950-9232&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0950-9232&client=summon