Magnolol Reduces Atopic Dermatitis-like Symptoms in BALB/c Mice
In traditional Korean medicines, is commonly included for the remedy of atopic dermatitis, and magnolol is a major constituent of . Its pharmacological effects include anti-inflammatory, hepatoprotective, and antioxidant effects. Using BALB/c mice repeatedly exposed to 1-chloro-2,4-dinitrobenzene (D...
Saved in:
Published in | Life (Basel, Switzerland) Vol. 14; no. 3; p. 339 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
01.03.2024
MDPI |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | In traditional Korean medicines,
is commonly included for the remedy of atopic dermatitis, and magnolol is a major constituent of
. Its pharmacological effects include anti-inflammatory, hepatoprotective, and antioxidant effects. Using BALB/c mice repeatedly exposed to 1-chloro-2,4-dinitrobenzene (DNCB), magnolol was evaluated in atopic dermatitis-like lesions. Administration of magnolol (10 mg/kg, intraperitoneal injection) markedly relieved the skin lesion severity including cracking, edema, erythema, and excoriation, and significantly inhibited the increase in IgE levels in the peripheral blood. A DNCB-induced increase in mast cell accumulation in atopic dermatitis skin lesions was reversed by magnolol administration, as well as a rise in expression levels of pro-inflammatory Th2/Th17/Th1 cytokines' (IL-4, IL-13, IL-17A, IFN-γ, IL-12A, TARC, IL-8, and IL-6) mRNAs in the lymph nodes and skin (n = 5 per group). In lymph nodes, magnolol reversed DNCB's increase in CD4
RORγt
Th17 cell fraction and decrease in CD4
FoxP3
regulatory T cell fraction. The results also showed that magnolol suppressed T cell differentiation into Th17 and Th2 cells, but not Th1 cells. Magnolol suppresses atopic dermatitis-like responses in the lymph nodes and skin, suggesting that it may be feasible to use it as a treatment for atopic dermatitis through its suppression of Th2/Th17 differentiation. |
---|---|
AbstractList | In traditional Korean medicines, Magnolia officinalis is commonly included for the remedy of atopic dermatitis, and magnolol is a major constituent of Magnolia officinalis. Its pharmacological effects include anti-inflammatory, hepatoprotective, and antioxidant effects. Using BALB/c mice repeatedly exposed to 1-chloro-2,4-dinitrobenzene (DNCB), magnolol was evaluated in atopic dermatitis-like lesions. Administration of magnolol (10 mg/kg, intraperitoneal injection) markedly relieved the skin lesion severity including cracking, edema, erythema, and excoriation, and significantly inhibited the increase in IgE levels in the peripheral blood. A DNCB-induced increase in mast cell accumulation in atopic dermatitis skin lesions was reversed by magnolol administration, as well as a rise in expression levels of pro-inflammatory Th2/Th17/Th1 cytokines’ (IL-4, IL-13, IL-17A, IFN-γ, IL-12A, TARC, IL-8, and IL-6) mRNAs in the lymph nodes and skin (n = 5 per group). In lymph nodes, magnolol reversed DNCB’s increase in CD4[sup.+] RORγt[sup.+] Th17 cell fraction and decrease in CD4[sup.+] FoxP3[sup.+] regulatory T cell fraction. The results also showed that magnolol suppressed T cell differentiation into Th17 and Th2 cells, but not Th1 cells. Magnolol suppresses atopic dermatitis-like responses in the lymph nodes and skin, suggesting that it may be feasible to use it as a treatment for atopic dermatitis through its suppression of Th2/Th17 differentiation. In traditional Korean medicines, Magnolia officinalis is commonly included for the remedy of atopic dermatitis, and magnolol is a major constituent of Magnolia officinalis. Its pharmacological effects include anti-inflammatory, hepatoprotective, and antioxidant effects. Using BALB/c mice repeatedly exposed to 1-chloro-2,4-dinitrobenzene (DNCB), magnolol was evaluated in atopic dermatitis-like lesions. Administration of magnolol (10 mg/kg, intraperitoneal injection) markedly relieved the skin lesion severity including cracking, edema, erythema, and excoriation, and significantly inhibited the increase in IgE levels in the peripheral blood. A DNCB-induced increase in mast cell accumulation in atopic dermatitis skin lesions was reversed by magnolol administration, as well as a rise in expression levels of pro-inflammatory Th2/Th17/Th1 cytokines' (IL-4, IL-13, IL-17A, IFN-γ, IL-12A, TARC, IL-8, and IL-6) mRNAs in the lymph nodes and skin (n = 5 per group). In lymph nodes, magnolol reversed DNCB's increase in CD4+RORγt+ Th17 cell fraction and decrease in CD4+FoxP3+ regulatory T cell fraction. The results also showed that magnolol suppressed T cell differentiation into Th17 and Th2 cells, but not Th1 cells. Magnolol suppresses atopic dermatitis-like responses in the lymph nodes and skin, suggesting that it may be feasible to use it as a treatment for atopic dermatitis through its suppression of Th2/Th17 differentiation. In traditional Korean medicines, is commonly included for the remedy of atopic dermatitis, and magnolol is a major constituent of . Its pharmacological effects include anti-inflammatory, hepatoprotective, and antioxidant effects. Using BALB/c mice repeatedly exposed to 1-chloro-2,4-dinitrobenzene (DNCB), magnolol was evaluated in atopic dermatitis-like lesions. Administration of magnolol (10 mg/kg, intraperitoneal injection) markedly relieved the skin lesion severity including cracking, edema, erythema, and excoriation, and significantly inhibited the increase in IgE levels in the peripheral blood. A DNCB-induced increase in mast cell accumulation in atopic dermatitis skin lesions was reversed by magnolol administration, as well as a rise in expression levels of pro-inflammatory Th2/Th17/Th1 cytokines' (IL-4, IL-13, IL-17A, IFN-γ, IL-12A, TARC, IL-8, and IL-6) mRNAs in the lymph nodes and skin (n = 5 per group). In lymph nodes, magnolol reversed DNCB's increase in CD4 RORγt Th17 cell fraction and decrease in CD4 FoxP3 regulatory T cell fraction. The results also showed that magnolol suppressed T cell differentiation into Th17 and Th2 cells, but not Th1 cells. Magnolol suppresses atopic dermatitis-like responses in the lymph nodes and skin, suggesting that it may be feasible to use it as a treatment for atopic dermatitis through its suppression of Th2/Th17 differentiation. In traditional Korean medicines, Magnolia officinalis is commonly included for the remedy of atopic dermatitis, and magnolol is a major constituent of Magnolia officinalis . Its pharmacological effects include anti-inflammatory, hepatoprotective, and antioxidant effects. Using BALB/c mice repeatedly exposed to 1-chloro-2,4-dinitrobenzene (DNCB), magnolol was evaluated in atopic dermatitis-like lesions. Administration of magnolol (10 mg/kg, intraperitoneal injection) markedly relieved the skin lesion severity including cracking, edema, erythema, and excoriation, and significantly inhibited the increase in IgE levels in the peripheral blood. A DNCB-induced increase in mast cell accumulation in atopic dermatitis skin lesions was reversed by magnolol administration, as well as a rise in expression levels of pro-inflammatory Th2/Th17/Th1 cytokines’ (IL-4, IL-13, IL-17A, IFN-γ, IL-12A, TARC, IL-8, and IL-6) mRNAs in the lymph nodes and skin (n = 5 per group). In lymph nodes, magnolol reversed DNCB’s increase in CD4 + RORγt + Th17 cell fraction and decrease in CD4 + FoxP3 + regulatory T cell fraction. The results also showed that magnolol suppressed T cell differentiation into Th17 and Th2 cells, but not Th1 cells. Magnolol suppresses atopic dermatitis-like responses in the lymph nodes and skin, suggesting that it may be feasible to use it as a treatment for atopic dermatitis through its suppression of Th2/Th17 differentiation. |
Audience | Academic |
Author | Lee, Ju-Hyun Im, Dong-Soon |
AuthorAffiliation | 2 Department of Fundamental Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea 1 Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea; ljh0620@khu.ac.kr |
AuthorAffiliation_xml | – name: 2 Department of Fundamental Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea – name: 1 Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea; ljh0620@khu.ac.kr |
Author_xml | – sequence: 1 givenname: Ju-Hyun surname: Lee fullname: Lee, Ju-Hyun organization: Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea – sequence: 2 givenname: Dong-Soon orcidid: 0000-0001-8054-8946 surname: Im fullname: Im, Dong-Soon organization: Department of Fundamental Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38541664$$D View this record in MEDLINE/PubMed |
BookMark | eNptkstv1DAQhy1URMvSG2cUiQtIpLXjR5xTtS2vlbZCauFsOfYkeEnirZ0g-t_jZUu1QdgH2-NvfvY8nqOjwQ-A0EuCzyit8HnnGiAMU5xOT9BJgUuek7Kojg72x-g0xg1OQ3AiJHuGjqnkjAjBTtDFtW4H3_kuuwE7GYjZcvRbZ7L3EHo9utHFvHM_ILu977ej72Pmhuxyub48N9m1M_ACPW10F-H0YV2gbx8_fL36nK-_fFpdLde54bQccyloZSQnhRSiksZCWQjDGTCWPm5lVTcFyBKoIFYD17WQJaHc4IJpqw3TdIFWe13r9UZtg-t1uFdeO_XH4EOrdBid6UCBoMJyQmpeaca1kIVgEhpLpOS0rnDSuthrbae6B2tgGIPuZqLzm8F9V63_qQiuyl0ISeHNg0LwdxPEUfUuGug6PYCfoqI4FQVXAsuEvv4H3fgpDClXiUplIxTLA6rVKQI3ND49bHaiallKWXC8Yxfo7D9UmhZ6Z1JnNC7ZZw5vZw6JGeHX2OopRrW6vZmz7_asCT7GAM1jQghWu2ZTh82W8FeHSXyE_7YW_Q2WxMvC |
Cites_doi | 10.1111/exd.12297 10.1186/s12906-015-0938-3 10.1038/jid.2008.111 10.1186/s13020-021-00555-7 10.1016/j.intimp.2015.10.023 10.1039/C8OB01745J 10.1248/yakushi1947.93.4_429 10.1080/1744666X.2022.2126353 10.1038/s41598-017-12628-5 10.1016/j.bcp.2003.09.040 10.3748/wjg.14.7353 10.1016/j.pharmthera.2011.01.010 10.1248/bpb.30.2201 10.1016/j.lfs.2018.01.016 10.1016/j.ejphar.2004.05.047 10.1016/j.ejphar.2007.01.095 10.4196/kjpp.2019.23.4.251 10.4062/biomolther.2020.036 10.1016/j.jaci.2003.12.007 10.1016/j.jaci.2016.03.010 10.1007/s13596-011-0004-8 10.1016/j.jep.2022.115162 10.3892/etm.2021.9876 10.1007/s11095-016-1953-x 10.3390/molecules15096452 10.4062/biomolther.2020.050 10.1016/S0140-6736(22)01539-2 10.1007/s10753-014-0003-2 10.1016/j.jep.2022.115023 10.1016/j.jep.2022.115061 10.1016/j.ejphar.2012.05.038 10.1007/BF00168746 10.1016/j.anai.2020.12.020 10.1055/s-2001-18354 |
ContentType | Journal Article |
Copyright | COPYRIGHT 2024 MDPI AG 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2024 by the authors. 2024 |
Copyright_xml | – notice: COPYRIGHT 2024 MDPI AG – notice: 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2024 by the authors. 2024 |
DBID | NPM AAYXX CITATION ISR 8FD 8FE 8FH ABUWG AFKRA ATCPS AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 GNUQQ HCIFZ LK8 M7P P64 PATMY PIMPY PQEST PQQKQ PQUKI PRINS PYCSY RC3 7X8 5PM DOA |
DOI | 10.3390/life14030339 |
DatabaseName | PubMed CrossRef Gale In Context: Science Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection AUTh Library subscriptions: ProQuest Central ProQuest Natural Science Collection ProQuest One Community College ProQuest Central Engineering Research Database ProQuest Central Student SciTech Premium Collection (Proquest) (PQ_SDU_P3) Biological Sciences Biological Science Database Biotechnology and BioEngineering Abstracts Environmental Science Database Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | PubMed CrossRef Publicly Available Content Database ProQuest Central Student Technology Research Database ProQuest Central Essentials ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Central Genetics Abstracts Natural Science Collection ProQuest Central Korea Agricultural & Environmental Science Collection Biological Science Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Biological Science Database ProQuest SciTech Collection Biotechnology and BioEngineering Abstracts Environmental Science Collection ProQuest One Academic UKI Edition Environmental Science Database Engineering Research Database ProQuest One Academic MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic Publicly Available Content Database CrossRef PubMed |
Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 2075-1729 |
ExternalDocumentID | oai_doaj_org_article_e636d511b59a45a682648efd18853b90 A788250003 10_3390_life14030339 38541664 |
Genre | Journal Article |
GeographicLocations | South Korea |
GeographicLocations_xml | – name: South Korea |
GrantInformation_xml | – fundername: National Research Foundation of Korea grantid: NRF-2023R1A2C2002380 – fundername: Korean Ministry of Science, ICT, and Future Planning grantid: NRF-2023R1A2C2002380 |
GroupedDBID | 53G 5VS 7XC 8FE 8FH AADQD AAFWJ ABDBF ADBBV AFKRA AFPKN AFZYC ALMA_UNASSIGNED_HOLDINGS AOIJS ATCPS BAWUL BBNVY BCNDV BENPR BHPHI CCPQU DIK ESX GROUPED_DOAJ HCIFZ HYE IAO ISR ITC KQ8 LK8 M48 M7P MODMG M~E NPM OK1 PATMY PGMZT PIMPY PROAC PYCSY RIG RPM AAYXX CITATION 8FD ABUWG AZQEC DWQXO FR3 GNUQQ P64 PQEST PQQKQ PQUKI PRINS RC3 7X8 5PM |
ID | FETCH-LOGICAL-c537t-8639c851286698cde726c54e44339d89bf2e87e361dae5ab687135c024adac4a3 |
IEDL.DBID | RPM |
ISSN | 2075-1729 |
IngestDate | Fri Oct 04 12:50:44 EDT 2024 Tue Sep 17 21:29:22 EDT 2024 Sat Aug 17 05:38:52 EDT 2024 Thu Oct 10 17:32:44 EDT 2024 Wed Jun 26 19:27:05 EDT 2024 Tue Jun 25 19:22:39 EDT 2024 Sat Sep 28 21:24:06 EDT 2024 Thu Sep 26 19:22:12 EDT 2024 Tue Oct 15 08:51:16 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Keywords | magnolia anti-atopy dermatitis magnolol Magnolia officinalis atopy atopic dermatitis |
Language | English |
License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c537t-8639c851286698cde726c54e44339d89bf2e87e361dae5ab687135c024adac4a3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0001-8054-8946 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10971286/ |
PMID | 38541664 |
PQID | 3003313088 |
PQPubID | 2032373 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_e636d511b59a45a682648efd18853b90 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10971286 proquest_miscellaneous_3014009608 proquest_journals_3003313088 gale_infotracmisc_A788250003 gale_infotracacademiconefile_A788250003 gale_incontextgauss_ISR_A788250003 crossref_primary_10_3390_life14030339 pubmed_primary_38541664 |
PublicationCentury | 2000 |
PublicationDate | 2024-03-01 |
PublicationDateYYYYMMDD | 2024-03-01 |
PublicationDate_xml | – month: 03 year: 2024 text: 2024-03-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | Switzerland |
PublicationPlace_xml | – name: Switzerland – name: Basel |
PublicationTitle | Life (Basel, Switzerland) |
PublicationTitleAlternate | Life (Basel) |
PublicationYear | 2024 |
Publisher | MDPI AG MDPI |
Publisher_xml | – name: MDPI AG – name: MDPI |
References | Dreier (ref_31) 2018; 16 Wei (ref_17) 2015; 38 Hijnen (ref_25) 2004; 113 Son (ref_8) 2019; 32 Lee (ref_13) 2011; 130 Shen (ref_28) 2010; 15 Jin (ref_9) 2011; 11 Flaherty (ref_37) 2015; 2015 Kong (ref_26) 2015; 29 Zhang (ref_14) 2022; 17 ref_15 Kim (ref_5) 2014; 23 Yang (ref_16) 2008; 14 Huang (ref_22) 2019; 23 Nam (ref_23) 2022; 289 Lee (ref_24) 2022; 291 Lee (ref_36) 2021; 29 Ikarashi (ref_27) 2001; 67 Tanaka (ref_32) 2007; 565 Yunhe (ref_18) 2012; 689 Labib (ref_1) 2022; 18 Paller (ref_3) 2022; 400 Kang (ref_35) 2020; 28 Fujita (ref_12) 1973; 93 Koga (ref_6) 2008; 128 Lin (ref_34) 2016; 33 Muraro (ref_7) 2016; 137 Hsu (ref_33) 2004; 67 Han (ref_21) 2007; 30 Park (ref_11) 2004; 496 Wang (ref_20) 1992; 346 Guo (ref_29) 2021; 21 Shen (ref_19) 2018; 196 Silverberg (ref_2) 2021; 126 Dreier (ref_30) 2017; 7 Lee (ref_10) 2022; 2022 ref_4 |
References_xml | – volume: 32 start-page: 94 year: 2019 ident: ref_8 article-title: The effects of orally administrated Gwakhyangjeonggi-san on DNCB-induced atopic dermatitis like mice model publication-title: J. Korean Med. Ophthalmol. Otolaryngol. Dermatol. contributor: fullname: Son – volume: 23 start-page: 53 year: 2014 ident: ref_5 article-title: Time-dependent progression from the acute to chronic phases in atopic dermatitis induced by epicutaneous allergen stimulation in NC/Nga mice publication-title: Exp. Dermatol. doi: 10.1111/exd.12297 contributor: fullname: Kim – ident: ref_15 doi: 10.1186/s12906-015-0938-3 – volume: 128 start-page: 2625 year: 2008 ident: ref_6 article-title: Possible pathogenic role of Th17 cells for atopic dermatitis publication-title: J. Investig. Derm. doi: 10.1038/jid.2008.111 contributor: fullname: Koga – volume: 17 start-page: 1 year: 2022 ident: ref_14 article-title: Compound traditional Chinese medicine dermatitis ointment ameliorates inflammatory responses and dysregulation of itch-related molecules in atopic dermatitis publication-title: Chin. Med. doi: 10.1186/s13020-021-00555-7 contributor: fullname: Zhang – volume: 29 start-page: 401 year: 2015 ident: ref_26 article-title: Icariin inhibits TNF-α/IFN-γ induced inflammatory response via inhibition of the substance P and p38-MAPK signaling pathway in human keratinocytes publication-title: Int. Immunopharmacol. doi: 10.1016/j.intimp.2015.10.023 contributor: fullname: Kong – volume: 16 start-page: 7019 year: 2018 ident: ref_31 article-title: Magnolol dimer-derived fragments as PPARγ-selective probes publication-title: Org. Biomol. Chem. doi: 10.1039/C8OB01745J contributor: fullname: Dreier – volume: 93 start-page: 429 year: 1973 ident: ref_12 article-title: Studies on the components of Magnolia obovata Thunb. 3. Occurrence of magnolol and hõnokiol in M. obovata and other allied plants publication-title: Yakugaku Zasshi doi: 10.1248/yakushi1947.93.4_429 contributor: fullname: Fujita – volume: 2015 start-page: e52739 year: 2015 ident: ref_37 article-title: Mouse naive CD4+ T cell isolation and in vitro differentiation into T cell subsets publication-title: JoVE (J. Vis. Exp.) contributor: fullname: Flaherty – volume: 18 start-page: 1107 year: 2022 ident: ref_1 article-title: An evaluation of abrocitinib for moderate-to-severe atopic dermatitis publication-title: Expert Rev. Clin. Immunol. doi: 10.1080/1744666X.2022.2126353 contributor: fullname: Labib – volume: 7 start-page: 13002 year: 2017 ident: ref_30 article-title: Linked magnolol dimer as a selective PPARγ agonist—Structure-based rational design, synthesis, and bioactivity evaluation publication-title: Sci. Rep. doi: 10.1038/s41598-017-12628-5 contributor: fullname: Dreier – volume: 67 start-page: 831 year: 2004 ident: ref_33 article-title: Mechanisms of the influence of magnolol on eicosanoid metabolism in neutrophils publication-title: Biochem. Pharm. doi: 10.1016/j.bcp.2003.09.040 contributor: fullname: Hsu – volume: 14 start-page: 7353 year: 2008 ident: ref_16 article-title: Magnolol attenuates sepsis-induced gastrointestinal dysmotility in rats by modulating inflammatory mediators publication-title: World J. Gastroenterol. WJG doi: 10.3748/wjg.14.7353 contributor: fullname: Yang – volume: 130 start-page: 157 year: 2011 ident: ref_13 article-title: Therapeutic applications of compounds in the Magnolia family publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2011.01.010 contributor: fullname: Lee – volume: 30 start-page: 2201 year: 2007 ident: ref_21 article-title: Magnolol and honokiol: Inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.30.2201 contributor: fullname: Han – volume: 196 start-page: 69 year: 2018 ident: ref_19 article-title: Magnolol treatment attenuates dextran sulphate sodium-induced murine experimental colitis by regulating inflammation and mucosal damage publication-title: Life Sci. doi: 10.1016/j.lfs.2018.01.016 contributor: fullname: Shen – volume: 496 start-page: 189 year: 2004 ident: ref_11 article-title: In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp. publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2004.05.047 contributor: fullname: Park – volume: 565 start-page: 212 year: 2007 ident: ref_32 article-title: Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB publication-title: Eur. J. Pharm. doi: 10.1016/j.ejphar.2007.01.095 contributor: fullname: Tanaka – volume: 23 start-page: 251 year: 2019 ident: ref_22 article-title: Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice publication-title: Korean J. Physiol. Pharmacol. doi: 10.4196/kjpp.2019.23.4.251 contributor: fullname: Huang – volume: 28 start-page: 537 year: 2020 ident: ref_35 article-title: Topical Application of S1P(2) Antagonist JTE-013 Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice publication-title: Biomol. Ther. doi: 10.4062/biomolther.2020.036 contributor: fullname: Kang – volume: 113 start-page: 334 year: 2004 ident: ref_25 article-title: Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell–attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2003.12.007 contributor: fullname: Hijnen – ident: ref_4 – volume: 137 start-page: 1347 year: 2016 ident: ref_7 article-title: Precision medicine in patients with allergic diseases: Airway diseases and atopic dermatitis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2016.03.010 contributor: fullname: Muraro – volume: 11 start-page: 71 year: 2011 ident: ref_9 article-title: Inhibition of chemokine, interleukin-8 expression in an atopic milieu by Pyeongwee-San extract (KMP6) publication-title: Orient. Pharm. Exp. Med. doi: 10.1007/s13596-011-0004-8 contributor: fullname: Jin – volume: 291 start-page: 115162 year: 2022 ident: ref_24 article-title: Inhibitory effect of α-cubebenoate on atopic dermatitis-like symptoms by regulating Th2/Th1/Th17 balance in vivo publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2022.115162 contributor: fullname: Lee – volume: 21 start-page: 448 year: 2021 ident: ref_29 article-title: Magnolol may contribute to barrier function improvement on imiquimod-induced psoriasis-like dermatitis animal model via the downregulation of interleukin-23 publication-title: Exp. Med. doi: 10.3892/etm.2021.9876 contributor: fullname: Guo – volume: 33 start-page: 2152 year: 2016 ident: ref_34 article-title: Methylation and Esterification of Magnolol for Ameliorating Cutaneous Targeting and Therapeutic Index by Topical Application publication-title: Pharm. Res. doi: 10.1007/s11095-016-1953-x contributor: fullname: Lin – volume: 15 start-page: 6452 year: 2010 ident: ref_28 article-title: Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders publication-title: Molecules doi: 10.3390/molecules15096452 contributor: fullname: Shen – volume: 29 start-page: 58 year: 2021 ident: ref_36 article-title: Suppressive Effect of Carnosol on Ovalbumin-Induced Allergic Asthma publication-title: Biomol. Ther. doi: 10.4062/biomolther.2020.050 contributor: fullname: Lee – volume: 400 start-page: 908 year: 2022 ident: ref_3 article-title: Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: A randomised, double-blind, placebo-controlled, phase 3 trial publication-title: Lancet doi: 10.1016/S0140-6736(22)01539-2 contributor: fullname: Paller – volume: 38 start-page: 16 year: 2015 ident: ref_17 article-title: Magnolol inhibits the inflammatory response in mouse mammary epithelial cells and a mouse mastitis model publication-title: Inflammation doi: 10.1007/s10753-014-0003-2 contributor: fullname: Wei – volume: 2022 start-page: 115023 year: 2022 ident: ref_10 article-title: Honokiol suppresses 2, 6-dinitrochlorobenzene-induced atopic dermatitis in mice publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2022.115023 contributor: fullname: Lee – volume: 289 start-page: 115061 year: 2022 ident: ref_23 article-title: In-vitro and in-vivo anti-allergic effects of magnolol on allergic rhinitis via inhibition of ORAI1 and ANO1 channels publication-title: J. Ethnopharmacol. doi: 10.1016/j.jep.2022.115061 contributor: fullname: Nam – volume: 689 start-page: 255 year: 2012 ident: ref_18 article-title: The effect of magnolol on the toll-like receptor 4/nuclear factor kappa B signaling pathway in lipopolysaccharide-induced acute lung injury in mice publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2012.05.038 contributor: fullname: Yunhe – volume: 346 start-page: 707 year: 1992 ident: ref_20 article-title: Anti-inflammatory and analgesic effects of magnolol publication-title: Naunyn-Schmiedeberg’s Arch. Pharmacol. doi: 10.1007/BF00168746 contributor: fullname: Wang – volume: 126 start-page: 417 year: 2021 ident: ref_2 article-title: Atopic dermatitis in the pediatric population: A cross-sectional, international epidemiologic study publication-title: Ann. Allergy Asthma Immunol. doi: 10.1016/j.anai.2020.12.020 contributor: fullname: Silverberg – volume: 67 start-page: 709 year: 2001 ident: ref_27 article-title: Effects of the extract of the bark of Magnolia obovata and its biphenolic constituents magnolol and honokiol on histamine release from peritoneal mast cells in rats publication-title: Planta Med. doi: 10.1055/s-2001-18354 contributor: fullname: Ikarashi |
SSID | ssj0000651684 |
Score | 2.3371203 |
Snippet | In traditional Korean medicines,
is commonly included for the remedy of atopic dermatitis, and magnolol is a major constituent of
. Its pharmacological effects... In traditional Korean medicines, Magnolia officinalis is commonly included for the remedy of atopic dermatitis, and magnolol is a major constituent of Magnolia... In traditional Korean medicines, Magnolia officinalis is commonly included for the remedy of atopic dermatitis, and magnolol is a major constituent of Magnolia... |
SourceID | doaj pubmedcentral proquest gale crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | 339 |
SubjectTerms | 1-Chloro-2,4-dinitrobenzene anti-atopy Asthma Atopic dermatitis atopy Care and treatment CD4 antigen Cell differentiation Cells Chemokines Chinese medicine Complications and side effects Cytokines Dermatitis Diagnosis Differentiation (biology) Dinitrobenzene Drug dosages Edema Erythema Foxp3 protein Helper cells Herbal medicine Hyperplasia Immunoglobulin E Inflammation Interleukins Lesions Lymph nodes Lymphatic system Lymphocytes Lymphocytes T magnolia Magnolia officinalis magnolol Medicine, Botanic Medicine, Herbal Pathogenesis Patient outcomes Peripheral blood Skin Skin diseases Skin lesions Surveys T cells γ-Interferon |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQJSQuiDeBggwCcYp287DjPVW7pVVBlENLpd4sPyYQsU1WTfbQf9-ZOF0l4sCltyieSPGM5xV9-YaxT5ihlJybNAZFn24gSdCl8CyngLW3tKYsbA-Q_SlPLvLvl-JyNOqLMGGBHjgobgYykx6rAisWJhdGKoJkQekThYnGLkK3nohRMxVisEikygPSPcO-frauSiBuunlGc8FHOain6v83II8y0hQtOUo_x0_Y46Fu5Mvwvk_ZA6ifsYdhkuTNc3ZwSoi5dbPmZ8TFCi1fds2mcvwrhJq0auN19Rf4-c3VpmuuWl7VfLX8sZo5foqx4gW7OD76dXgSD7MRYieyoosVVhYOq6VUSblQzkORSidyyHPcn1cLW6agCshk4g0IY6WiWXwOM7LxxuUme8n26qaG14wDJGBUahKMi7m0eA1zm6TWu6IovPcR-3ynLb0JFBgaWwfSqh5rNWIrUuVOhoir-xtoTj2YU__PnBH7SIbQRE1RE_blt9m2rf52fqaX2K2nNL8hi9iXQahs0CTODL8S4H6IzWoiuT-RRN9x0-U7e-vBd1ud0Xw7TO1KRezDbpmeJDxaDc2WZHDX1P2hzKtwPHb7zpTAKlfmEVOTgzNRzHSlrv70zN4EByCTvrkPVb5lj1K0dwDM7bO97noL77CC6uz73lluAWhMFPQ priority: 102 providerName: Directory of Open Access Journals – databaseName: AUTh Library subscriptions: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELdgExIviG8CAwUE4ilq4ziO8zS1sGkgNqGOSXuzHPsyIrqkLOnD_nvuErc0QuItii9RfN-2f7lj7D1GKCWnhkegaOsG4hhNCnWZA-besjBlVvQA2TN5ciG-XqaXfsOt9bDKjU_sHbVrLO2RTxLqOoYOV6nD1e-IukbR6apvoXGX7fNY0DHt_vzo7Ptiu8uCATaWSgyI9wTX95NlVQLVqMO35aNY1Jfs_9cx70SmMWpyJwwdP2QPfP4YzgaBP2J3oH7M7g0dJW-fsMNTQs4tm2W4oJqs0IazrllVNvwMQ25atdGy-gXh-e31qmuu27Cqw_ns23xiw1P0GU_ZxfHRj08nke-RENk0ybpIYYZhMWviSspcWQcZlzYVIATOz6m8KDmoDBIZOwOpKaSinnwWI7NxxgqTPGN7dVPDCxYCxGAUNzH6RyELvIZpEfPC2SzLnHMB-7Dhll4NpTA0LiGIq3qXqwGbEyu3NFTAur_R3Fxpbw8aZCIdJntFmhuRGqkIaQelixXmD0U-Ddg7EoSmEhU1YWCuzLpt9ZfzhZ7hqp1TH4ckYB89UdmgSKzxvxTgfKiq1YjyYESJNmTHwxt5a2_Drf6rcQF7ux2mJwmXVkOzJhqcNa0Ckeb5oB7beScqRZWUImBqpDgjxoxH6upnX-GbYAEk0pf__65X7D5HSQ6QuAO2192s4TXmSF3xxhvCHxiKDqo priority: 102 providerName: ProQuest – databaseName: Scholars Portal Open Access Journals dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9NAEF6VIiQuiHdNCzIIxMk0Xq_XmwOqEqAqiHBoidTbanc9LhauncaORP49M7YTxSpHbrZ3fNh57HxjfZ5h7C1mKCVHhgeg6NMNhCGGFPoyB8Te0possS1B9oc8m4tvl_HlHttMG-0VWP-ztKN5UvNl8eHPzfoEA_4jVZxYsh8XeQbUdm6Ed3fYXS4iQb4-64F-dybHoVSiY77femmQk9rW_bcP6J0MNWRP7qSj04fsQY8j_Uln-EdsD8rH7F43WXL9hJ3MiEFXVIV_Tr1ZofYnTbXInf8ZOoya10GR_wb_Yn29aKrr2s9Lfzr5Pj12_gzPjqdsfvrl56ezoJ-VELg4SppAIdJwiJ64knKsXAoJly4WIATuL1Vjm3FQCUQyTA3ExkpFs_kcZmiTGidM9Iztl1UJB8wHCMEobkI8J4W0eA0jG3KbuiRJ0jT12LuNtvSia4mhsZQgrepdrXpsSqrcylAj6_ZBtbzSfVxokJFMEfTZeGxEbKQixh1kaagQR9jxyGNvyBCaWlWUxIW5Mqu61l8vzvUEq3dO8xwij73vhbIKTeJM_2sB7oe6Ww0kjwaSGEtuuLyxt964oo5o3h2meqU89nq7TG8SP62EakUyuGuqBlHmeece231HKkbUK4XH1MBxBooZrpT5r7bTN9EDyKQv_ocqD9l9jvbuCHRHbL9ZruAlIqrGvmqD5S_EAByH priority: 102 providerName: Scholars Portal |
Title | Magnolol Reduces Atopic Dermatitis-like Symptoms in BALB/c Mice |
URI | https://www.ncbi.nlm.nih.gov/pubmed/38541664 https://www.proquest.com/docview/3003313088 https://search.proquest.com/docview/3014009608 https://pubmed.ncbi.nlm.nih.gov/PMC10971286 https://doaj.org/article/e636d511b59a45a682648efd18853b90 |
Volume | 14 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb5tAEF4lqSr1UqXP0KQWrVr1RDAsLOtTZaeJ0qqOIqeRckO7y5CiYrACPuTfd4aHBeqtF8vyDpJ3ZnbmG_iYYewTZigppsp3QNKtG_A8PFLoyz4g9hZapZFuCLJX4vI2-HEX3u0x0b8L05D2jc5Oi3x9WmS_G27lZm3cnifmXi_P6KkpxlXh7rP9iPNBjd7G39ATMmhZ7hxrejfPUqC-dFNOM8EH-adp0_9vMB5kozFTcpB6Lg7Z8w4z2vP2v71ge1C8ZE_bKZKPr9jXJbHl8jK3V9SHFSp7XpebzNjfoMWjWeXk2R-wbx7Xm7pcV3ZW2Iv5z4Vr7CXGidfs9uL819ml081FcEzIo9qRiCoMIiXUgJhJk0DkCxMGEAS4v0TOdOqDjIALL1EQKi0kzeEzmI1Vokyg-Bt2UJQFHDEbwAMlfeVhTAyExu8w1Z6vExNFUZIkFvvcayvetO0vYiwbSKvxUKsWW5AqdzLUtLr5oXy4jzvTxSC4SBDg6XCmglAJSew6SBNPImbQs6nFPpIhYmpLURDv5V5tqyr-frOK51ip-zS7gVvsSyeUlmgSo7rXCHA_1MlqJHkyksRzY8bLvb3j7txWMafZdpjWpbTYh90yXUlctALKLcngrqnyQ5m3rXvs9s1liAhXBBaTI8cZKWa8gk7edPXunfrd_196zJ75aOWWInfCDuqHLbxHzFTrCXuyOL-6Xk2aew74uQzkpDk2fwGqJRh2 |
link.rule.ids | 230,315,733,786,790,870,891,2115,2236,21416,24346,27955,27956,33777,33778,43838,53825,53827,74657 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9NAEF5BKgQXxBtDAYNAnKzEr_X6VCXQKoUkQmkr9bbax7hYpHaonUP_PTO2E2IhcYu8Yys7szPz7frzDGMfMUMJPlKBB4KObsD30aVwLQeA2JtrlSW6Icgu-PQi-nYZX3YHblVHq9zGxCZQ29LQGfkwpK5jGHCFOFr_9qhrFL1d7Vpo3GUHVHJTDNjB5HjxY7k7ZcEE63MRtYz3EPf3w1WeAdWow6elvVzUlOz_NzDvZaY-a3IvDZ08Yg87_OiOW4M_ZnegeMLutR0lb5-yozkx51blyl1STVao3HFdrnPjfoUWm-aVt8p_gXt2e72uy-vKzQt3Mp5NhsadY8x4xi5Ojs-_TL2uR4Jn4jCpPYEIwyBqCgTnqTAWkoCbOIIowvlZkeosAJFAyH2rIFaaC-rJZzAzK6tMpMLnbFCUBbxkLoAPSgTKx_gYcY2_YaT9QFuTJIm11mGfttqS67YUhsQtBGlV7mvVYRNS5U6GClg3F8qbK9n5gwQecotgT8epimLFBTHtILO-QPyg05HDPpAhJJWoKIgDc6U2VSVPz5ZyjLv2gPo4hA773AllJZrEqO6TApwPVbXqSR72JNGHTH94a2_Z-XAl_644h73fDdOdxEsroNyQDM6adoEo86JdHrt5hyJGtMsjh4newukppj9S5D-bCt9ECyCTvvr__3rH7k_P5zM5O118f80eBGjVlh53yAb1zQbeIF6q9dvOKf4ADYsRoA |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9NAEF5BKxAXxLMYChgE4mQlfq03pyqhjVpooyqlUm-rfYyLRWqH2jn03zNjb0IsJG5RdhJlZ3Zmvll_mWHsE2YowYcqCkDQ1Q2EIboUnuUIEHtzrfJMtwTZGT--TL5dpVeO_1Q7WuU6JraB2laG7sgHMU0dw4CLBVvuaBHnh9OD5e-AJkjRk1Y3TuM-280SnmIhtjs5mp3PNzcumGxDLpKO_R5jrT9YFDlQvzr85lEvL7Xt-_8N0ltZqs-g3EpJ0yfsscOS_rgz_lN2D8pn7EE3XfLuOTs4Ixbdolr4c-rPCrU_bqplYfxD6HBqUQeL4hf4F3c3y6a6qf2i9Cfj08nA-GcYP16wy-nRj6_HgZuXEJg0zppAINowiKAiwflIGAtZxE2aQJLg_qwY6TwCkUHMQ6sgVZoLms9nMEsrq0yi4pdsp6xKeMV8gBCUiFSIsTLhGl_DUIeRtibLMmutxz6vtSWXXVsMieUEaVVua9VjE1LlRoaaWbdvVLfX0vmGBB5zi8BPpyOVpIoLYt1BbkOBWEKPhh77SIaQ1K6iJMNfq1Vdy5OLuRxjBR_RTIfYY1-cUF6hSYxyfy_A_VCHq57kfk8S_cn0l9f2ls6fa_n39Hnsw2aZPkkctRKqFcngrqkiRJm97nhs9h2LFJEvTzwmegenp5j-Sln8bLt9E0WATPr6_7_rPXuI_iBPT2bf37BHERq1Y8rts53mdgVvETo1-p3ziT8BvBXU |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Magnolol+Reduces+Atopic+Dermatitis-like+Symptoms+in+BALB%2Fc+Mice&rft.jtitle=Life+%28Basel%2C+Switzerland%29&rft.au=Ju-Hyun+Lee&rft.au=Dong-Soon+Im&rft.date=2024-03-01&rft.pub=MDPI+AG&rft.eissn=2075-1729&rft.volume=14&rft.issue=3&rft.spage=339&rft_id=info:doi/10.3390%2Flife14030339&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_e636d511b59a45a682648efd18853b90 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2075-1729&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2075-1729&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2075-1729&client=summon |