Semicarbazide-Sensitive Amine Oxidase Increases in Calcific Aortic Valve Stenosis and Contributes to Valvular Interstitial Cell Calcification

• Published in: Oxidative medicine and cellular longevity Vol. 2020; no. 2020; pp. 1 - 9
• Main Authors: Bäck, Magnus, Wollensack, Bastien, Persson, Oscar, Carracedo, Miguel, Pirault, John, Pawelzik, Sven-Christian, Mercier, Nathalie, Franco-Cereceda, Anders
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc
• Subjects: Amine Oxidase (Copper-Containing) - antagonists & inhibitors; Amine Oxidase (Copper-Containing) - genetics; Amine Oxidase (Copper-Containing) - metabolism; Analysis; Aortic Valve - enzymology; Aortic Valve - pathology; Aortic valve stenosis; Aortic Valve Stenosis - enzymology; Aortic Valve Stenosis - genetics; Aortic Valve Stenosis - pathology; Calcification; Calcinosis - enzymology; Calcinosis - genetics; Calcinosis - pathology; Diabetes Mellitus - enzymology; Diabetes Mellitus - genetics; Enzymes; Gene expression; Humans; Hydrogen peroxide; Immunohistochemistry; Laboratories; Obesity - enzymology; Obesity - genetics; Oxidases; Oxidative Stress; Proteins; Risk factors; RNA; RNA, Messenger - genetics; RNA, Messenger - metabolism; Scientific equipment and supplies industry; Smoking - adverse effects; Type 2 diabetes; Australia; United States; Sweden; United States > US; Germany

Introduction. Calcific aortic valve stenosis (CAVS) is a common disease associated with aging. Oxidative stress participates in the valve calcification process in CAVS. Semicarbazide-sensitive amine oxidase (SSAO), also referred to as vascular adhesion protein 1 (VAP-1), transforms primary amines in...