Microglia priming by interleukin-6 signaling is enhanced in aged mice

• Published in: Journal of neuroimmunology Vol. 324; pp. 90 - 99
• Main Authors: Garner, Katherine M., Amin, Ravi, Johnson, Rodney W., Scarlett, Emily J., Burton, Michael D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.11.2018
• Subjects: Aging - drug effects; Aging - immunology; Aging - metabolism; Animals; Cell Line; IL-6 trans signaling; Inflammation; Interleukin-6 - biosynthesis; Interleukin-6 - genetics; Interleukin-6 - immunology; Lipopolysaccharides - toxicity; Male; MHC-II; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia - drug effects; Microglia - immunology; Microglia - metabolism; Neuroimmunology; Signal Transduction - physiology; STAT3; Inflammation; IL-6; LPS; sgp130; IL-6 trans signaling; TNF-α; sIL-6R; gp130; Neuroimmunology; IL-1B; CD68; CD45; MHC-II

During peripheral infection, excessive production of pro-inflammatory cytokines in the aged brain from primed microglia induces exaggerated behavioral pathologies. While the pro-inflammatory cytokine IL-6 increases in the brain with age, its role in microglia priming is not known. This study examine...