Laminin: loss-of-function studies

• Published in: Cellular and molecular life sciences : CMLS Vol. 74; no. 6; pp. 1095 - 1115
• Main Author: Yao, Yao
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2017; Springer Nature B.V
• Subjects: Animal models; Animals; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Developmental stages; Embryogenesis; Embryonic growth stage; Extracellular matrix; Genotype & phenotype; Humans; Laminin; Laminin - chemistry; Laminin - metabolism; Life Sciences; Life span; longevity; loss-of-function mutation; Mutants; Mutation; Nomenclature; phenotype; Phenotypes; Protein expression; Protein Isoforms - chemistry; Protein Isoforms - metabolism; Review; Terminology as Topic; Loss-of-function; Animal model; Laminin; Knockout; Basement membrane

Laminin, one of the most widely expressed extracellular matrix proteins, exerts many important functions in multiple organs/systems and at various developmental stages. Although its critical roles in embryonic development have been demonstrated, laminin’s functions at later stages remain largely unk...