Association between SARS-CoV-2 Neutralizing Antibodies and Commercial Serological Assays

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 66; no. 12; pp. 1538 - 1547
• Main Authors: Tang, Mei San, Case, James Brett, Franks, Caroline E, Chen, Rita E, Anderson, Neil W, Henderson, Jeffrey P, Diamond, Michael S, Gronowski, Ann M, Farnsworth, Christopher W
• Format: Journal Article
• Language: English
• Published: Washington Oxford University Press 01.12.2020; American Association for Clinical Chemistry, Inc
• Subjects: Analysis; Antibodies; Antibody response; Antigens; Assaying; Control; Coronaviruses; COVID-19; Epidemics; Immunoglobulin G; Methods; Neutralization; Neutralizing; Patients; Qualitative analysis; Serodiagnosis; Serology; Severe acute respiratory syndrome coronavirus 2; United States; Viral antigens; Viral diseases; Viral proteins; United States; COVID-19; neutralizing antibodies; SARS-CoV-2; Serology

Abstract Background Commercially available SARS-CoV-2 serological assays based on different viral antigens have been approved for the qualitative determination of anti-SARS-CoV-2 antibodies. However, there are limited published data associating the results from commercial assays with neutralizing an...