Effects of Alkaline Solutions on the Structure and Function of Influenza A Virus

• Published in: Viruses Vol. 16; no. 10; p. 1636
• Main Authors: Seguchi, Manato, Yamaguchi, Seiji, Tanaka, Mamoru, Mori, Yukihiro, Tsurudome, Masato, Ito, Morihiro
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.10.2024; MDPI
• Subjects: Acids; Alkalies - pharmacology; alkaline condition; Animals; Care and treatment; Diagnosis; Disinfectants; Disinfectants - pharmacology; Disinfection & disinfectants; Dogs; Epidemics; Health aspects; hemagglutinin; Hemagglutinin Glycoproteins, Influenza Virus - chemistry; Hemagglutinin Glycoproteins, Influenza Virus - metabolism; Hemagglutinins; Humans; Hydrogen-Ion Concentration; hydrolysis; Infections; Infectivity; Influenza; Influenza A; influenza A virus; Influenza A virus - drug effects; Influenza A virus - physiology; Madin Darby Canine Kidney Cells; Microorganisms; Monoclonal antibodies; Morbidity; pH effects; Proteins; Solutions; Structure-function relationships; Viral infections; Virus Inactivation - drug effects; Viruses; Japan; United States > US; alkaline condition; hemagglutinin; hydrolysis; influenza A virus

Influenza A virus (IAV) infection contributes to high annual morbidity and mortality, thus necessitating measures aimed at protecting against the disease. Alcohol-based disinfectants are commonly used to inactivate IAV, but they have several undesirable properties. In search of other means which wou...