Improved Differentiation of Low-Grade and High-Grade Gliomas and Detection of Tumor Proliferation Using APT Contrast Fitted from Z-Spectrum

• Published in: Molecular imaging and biology Vol. 20; no. 4; pp. 623 - 631
• Main Authors: Zhang, Jiaxuan, Zhu, Wenzhen, Tain, Rongwen, Zhou, Xiaohong Joe, Cai, Kejia
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2018; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Amides - chemistry; Brain Neoplasms - diagnosis; Brain Neoplasms - pathology; Cell Proliferation; Correlation; Diagnostic systems; Differentiation; Female; Glioma; Glioma - diagnosis; Glioma - pathology; Histopathology; Humans; Imaging; Ki-67 Antigen - metabolism; Magnetic Resonance Imaging; Magnetization; Male; Medicine; Medicine & Public Health; Middle Aged; Protons; Quality; Radiology; Research Article; ROC Curve; Saturation; Semisolids; Solid tumors; Spectra; Tissue analysis; Tissues; Young Adult; Z-spectrum; Ki-67 labeling index; APT contrast; Glioma; Tumor proliferation

Purpose The purpose of the study is to demonstrate the value of quantitative amide proton transfer (APT) imaging for differentiating glioma grades and detecting tumor proliferation. Procedures This study included 32 subjects with 16 low-grade gliomas (LGG) and 16 high-grade gliomas (HGG) confirmed b...