Prefrontal Regulation of Punished Ethanol Self-administration

• Published in: Biological psychiatry (1969) Vol. 87; no. 11; pp. 967 - 978
• Main Authors: Halladay, Lindsay R., Kocharian, Adrina, Piantadosi, Patrick T., Authement, Michael E., Lieberman, Abby G., Spitz, Nathen A., Coden, Kendall, Glover, Lucas R., Costa, Vincent D., Alvarez, Veronica A., Holmes, Andrew
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2020
• Subjects: Alcohol; Amygdala; Animals; Compulsive; Corticostriatal; Ethanol; Infralimbic; Mice; Mouse; Nucleus Accumbens; Prefrontal Cortex; Punishment; Self Administration; Nucleus accumbens; Amygdala; Mouse; Compulsive; Alcohol; Corticostriatal; Infralimbic

A clinical hallmark of alcohol use disorder is persistent drinking despite potential adverse consequences. The ventromedial prefrontal cortex (vmPFC) and dorsomedial prefrontal cortex (dmPFC) are positioned to exert top-down control over subcortical regions, such as the nucleus accumbens shell (NAcS...