Cannabis use and sleep quality in daily life: An electronic daily diary study of adults starting cannabis for health concerns

• Published in: Drug and alcohol dependence Vol. 243; p. 109760
• Main Authors: Tervo-Clemmens, Brenden, Schmitt, William, Wheeler, Grace, Cooke, Megan E., Schuster, Randi M., Hickey, Sarah, Pachas, Gladys N., Evins, A. Eden, Gilman, Jodi M.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.02.2023
• Subjects: Adult; Cannabis; Clinical trial; Daily diary; Humans; Longitudinal; Medical Marijuana - therapeutic use; Mood; Pain; Sleep; Sleep Quality; Cannabis; Longitudinal; Sleep; Pain; Mood; Clinical trial; Daily diary
• DOI: 10.1016/j.drugalcdep.2022.109760
• ISSN: 0376-8716; 1879-0046

Real world patterns of cannabis use for health concerns are highly variable and rarely overseen by a physician. Pragmatic effectiveness studies with electronic daily diaries that capture person-specific patterns of cannabis use and health symptoms may help clarify risks and benefits. As part of a larger, randomized trial (NCT03224468), adults (N = 181) seeking cannabis for insomnia, pain, or anxiety or depressive symptoms were randomized to obtain a medical cannabis card immediately (MCC) or a waitlist control (WLC) and completed 12-weeks of daily web-based surveys on cannabis use and sleep, pain, and depressive symptoms. Completion rates of daily surveys were moderate to high (median completed: 72 out of 90 days). Daily reports of cannabis use were consistent with monthly interview assessments and urinalysis. The MCC group increased cannabis use frequency in the 12 weeks following randomization, while WLC did not. Among the MCC group, self-reported sleep quality was significantly higher on cannabis use days, compared to nonuse days. The MCC group displayed long-term sleep improvements, consistent with increasing cannabis frequency. No improvements were found for pain or depressive symptoms. Cannabis use is associated with same day improvements in self-reported sleep quality, but not pain or depressive symptoms, although sleep improvements occurred in the context of increased frequency of cannabis use, raising the risk for cannabis use disorder. Daily web-based assessments of cannabis appear valid and feasible in adults seeking cannabis for health concerns, providing a flexible, complementary method for future real-world effectiveness studies with expanded and objective measures. •Daily diaries are well-suited to variable, real-world use for health concerns.•Daily diary reports align with cannabis assessments from interviews and urinalysis.•Adults randomized to medical cannabis cards (MCC) report better sleep on use days than non-use days.•Long-term improvements in sleep parallel increases in the frequency of use days.•No cannabis-related improvements are seen for pain and mood symptoms.