A New Fork for Clinical Application: Targeting Forkhead Transcription Factors in Cancer

• Published in: Clinical cancer research Vol. 15; no. 3; pp. 752 - 757
• Main Authors: Yang, Jer-Yen, Hung, Mien-Chie
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.02.2009
• Subjects: Antineoplastic agents; Biological and medical sciences; cancer; Cell Nucleus - metabolism; Drug Delivery Systems; Forkhead Box Protein O3; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - physiology; FOXO3a; Gene Expression Regulation, Neoplastic; Humans; Medical sciences; Models, Biological; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - therapy; Pharmacology. Drug treatments; Protein Kinases - physiology; Signal Transduction - drug effects; therapy; Signal transduction; Target; Targeting; Malignant tumor; Transcription factor; Application; Cancer

Forkhead O transcription factors (FOXO) play a pivotal role in the regulation of a myriad of cellular functions including cell cycle arrest, cell death, and protection from stress stimuli. Activation of cell survival pathways such as phosphoinositide-3-kinase/AKT/IKK or RAS/mitogen-activated protein...