Variation in genomic landscape of clear cell renal cell carcinoma across Europe

• Published in: Nature communications Vol. 5; no. 1; p. 5135
• Main Authors: Scelo, Ghislaine, Riazalhosseini, Yasser, Greger, Liliana, Letourneau, Louis, Gonzàlez-Porta, Mar, Wozniak, Magdalena B., Bourgey, Mathieu, Harnden, Patricia, Egevad, Lars, Jackson, Sharon M., Karimzadeh, Mehran, Arseneault, Madeleine, Lepage, Pierre, How-Kit, Alexandre, Daunay, Antoine, Renault, Victor, Blanché, Hélène, Tubacher, Emmanuel, Sehmoun, Jeremy, Viksna, Juris, Celms, Edgars, Opmanis, Martins, Zarins, Andris, Vasudev, Naveen S., Seywright, Morag, Abedi-Ardekani, Behnoush, Carreira, Christine, Selby, Peter J., Cartledge, Jon J., Byrnes, Graham, Zavadil, Jiri, Su, Jing, Holcatova, Ivana, Brisuda, Antonin, Zaridze, David, Moukeria, Anush, Foretova, Lenka, Navratilova, Marie, Mates, Dana, Jinga, Viorel, Artemov, Artem, Nedoluzhko, Artem, Mazur, Alexander, Rastorguev, Sergey, Boulygina, Eugenia, Heath, Simon, Gut, Marta, Bihoreau, Marie-Therese, Lechner, Doris, Foglio, Mario, Gut, Ivo G., Skryabin, Konstantin, Prokhortchouk, Egor, Cambon-Thomsen, Anne, Rung, Johan, Bourque, Guillaume, Brennan, Paul, Tost, Jörg, Banks, Rosamonde E., Brazma, Alvis, Lathrop, G. Mark
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.10.2014; Nature Publishing Group
• Subjects: 631/208/69; 631/67/2324; 631/67/589/1588/1351; Adult; Aged; Aged, 80 and over; Biochemistry, Molecular Biology; Cancer research; Carcinoma, Renal Cell - genetics; Cohort Studies; Epidemiology; Epigenetics; Europe; Female; Focal Adhesions - metabolism; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Variation; Genome, Human - genetics; Genomes; Genomics; Hospitals; Humanities and Social Sciences; Humans; Kidney cancer; Life Sciences; Male; Medical research; Medicin och hälsovetenskap; Middle Aged; multidisciplinary; Mutation; Mutation Rate; Oncogene Proteins, Fusion - genetics; Pathology; Phosphatidylinositol 3-Kinases - genetics; Public health; RNA Splicing - genetics; Science; Science (multidisciplinary); Sequence Analysis, DNA; Signal Transduction - genetics; Europe; Canada; Czech Republic; Romania; United Kingdom > UK; Quebec Canada; Montreal Quebec Canada; France; Russia

The incidence of renal cell carcinoma (RCC) is increasing worldwide, and its prevalence is particularly high in some parts of Central Europe. Here we undertake whole-genome and transcriptome sequencing of clear cell RCC (ccRCC), the most common form of the disease, in patients from four different Eu...