Variation in genomic landscape of clear cell renal cell carcinoma across Europe

The incidence of renal cell carcinoma (RCC) is increasing worldwide, and its prevalence is particularly high in some parts of Central Europe. Here we undertake whole-genome and transcriptome sequencing of clear cell RCC (ccRCC), the most common form of the disease, in patients from four different Eu...

Full description

Saved in:

Bibliographic Details
Published in	Nature communications Vol. 5; no. 1; p. 5135
Main Authors	Scelo, Ghislaine, Riazalhosseini, Yasser, Greger, Liliana, Letourneau, Louis, Gonzàlez-Porta, Mar, Wozniak, Magdalena B., Bourgey, Mathieu, Harnden, Patricia, Egevad, Lars, Jackson, Sharon M., Karimzadeh, Mehran, Arseneault, Madeleine, Lepage, Pierre, How-Kit, Alexandre, Daunay, Antoine, Renault, Victor, Blanché, Hélène, Tubacher, Emmanuel, Sehmoun, Jeremy, Viksna, Juris, Celms, Edgars, Opmanis, Martins, Zarins, Andris, Vasudev, Naveen S., Seywright, Morag, Abedi-Ardekani, Behnoush, Carreira, Christine, Selby, Peter J., Cartledge, Jon J., Byrnes, Graham, Zavadil, Jiri, Su, Jing, Holcatova, Ivana, Brisuda, Antonin, Zaridze, David, Moukeria, Anush, Foretova, Lenka, Navratilova, Marie, Mates, Dana, Jinga, Viorel, Artemov, Artem, Nedoluzhko, Artem, Mazur, Alexander, Rastorguev, Sergey, Boulygina, Eugenia, Heath, Simon, Gut, Marta, Bihoreau, Marie-Therese, Lechner, Doris, Foglio, Mario, Gut, Ivo G., Skryabin, Konstantin, Prokhortchouk, Egor, Cambon-Thomsen, Anne, Rung, Johan, Bourque, Guillaume, Brennan, Paul, Tost, Jörg, Banks, Rosamonde E., Brazma, Alvis, Lathrop, G. Mark
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 29.10.2014 Nature Publishing Group
Subjects	631/208/69 631/67/2324 631/67/589/1588/1351 Adult Aged Aged, 80 and over Biochemistry, Molecular Biology Cancer research Carcinoma, Renal Cell - genetics Cohort Studies Epidemiology Epigenetics Europe Female Focal Adhesions - metabolism Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic Variation Genome, Human - genetics Genomes Genomics Hospitals Humanities and Social Sciences Humans Kidney cancer Life Sciences Male Medical research Medicin och hälsovetenskap Middle Aged multidisciplinary Mutation Mutation Rate Oncogene Proteins, Fusion - genetics Pathology Phosphatidylinositol 3-Kinases - genetics Public health RNA Splicing - genetics Science Science (multidisciplinary) Sequence Analysis, DNA Signal Transduction - genetics Europe Canada Czech Republic Romania United Kingdom > UK Quebec Canada Montreal Quebec Canada France Russia
Online Access	Get full text

Cover

Loading…

Abstract	The incidence of renal cell carcinoma (RCC) is increasing worldwide, and its prevalence is particularly high in some parts of Central Europe. Here we undertake whole-genome and transcriptome sequencing of clear cell RCC (ccRCC), the most common form of the disease, in patients from four different European countries with contrasting disease incidence to explore the underlying genomic architecture of RCC. Our findings support previous reports on frequent aberrations in the epigenetic machinery and PI3K/mTOR signalling, and uncover novel pathways and genes affected by recurrent mutations and abnormal transcriptome patterns including focal adhesion, components of extracellular matrix (ECM) and genes encoding FAT cadherins. Furthermore, a large majority of patients from Romania have an unexpected high frequency of A:T>T:A transversions, consistent with exposure to aristolochic acid (AA). These results show that the processes underlying ccRCC tumorigenesis may vary in different populations and suggest that AA may be an important ccRCC carcinogen in Romania, a finding with major public health implications. Renal cancer accounts for 2.4% of all adult cancers and its incidence is increasing worldwide. Here, the authors carry out genome and transcriptome sequencing of clear cell renal cell carcinomas (ccRCCs) and highlight genomic aberrations and biological pathways underlying ccRCC tumorigenesis.
AbstractList	The incidence of renal cell carcinoma (RCC) is increasing worldwide, and its prevalence is particularly high in some parts of Central Europe. Here we undertake whole-genome and transcriptome sequencing of clear cell RCC (ccRCC), the most common form of the disease, in patients from four different European countries with contrasting disease incidence to explore the underlying genomic architecture of RCC. Our findings support previous reports on frequent aberrations in the epigenetic machinery and PI3K/mTOR signalling, and uncover novel pathways and genes affected by recurrent mutations and abnormal transcriptome patterns including focal adhesion, components of extracellular matrix (ECM) and genes encoding FAT cadherins. Furthermore, a large majority of patients from Romania have an unexpected high frequency of A:T>T:A transversions, consistent with exposure to aristolochic acid (AA). These results show that the processes underlying ccRCC tumorigenesis may vary in different populations and suggest that AA may be an important ccRCC carcinogen in Romania, a finding with major public health implications. Renal cancer accounts for 2.4% of all adult cancers and its incidence is increasing worldwide. Here, the authors carry out genome and transcriptome sequencing of clear cell renal cell carcinomas (ccRCCs) and highlight genomic aberrations and biological pathways underlying ccRCC tumorigenesis. The incidence of renal cell carcinoma (RCC) is increasing worldwide, and its prevalence is particularly high in some parts of Central Europe. Here we undertake whole-genome and transcriptome sequencing of clear cell RCC (ccRCC), the most common form of the disease, in patients from four different European countries with contrasting disease incidence to explore the underlying genomic architecture of RCC. Our findings support previous reports on frequent aberrations in the epigenetic machinery and PI3K/mTOR signalling, and uncover novel pathways and genes affected by recurrent mutations and abnormal transcriptome patterns including focal adhesion, components of extracellular matrix (ECM) and genes encoding FAT cadherins. Furthermore, a large majority of patients from Romania have an unexpected high frequency of A:T>T:A transversions, consistent with exposure to aristolochic acid (AA). These results show that the processes underlying ccRCC tumorigenesis may vary in different populations and suggest that AA may be an important ccRCC carcinogen in Romania, a finding with major public health implications.
ArticleNumber	5135
Author	Harnden, Patricia Abedi-Ardekani, Behnoush Selby, Peter J. Rung, Johan Renault, Victor Viksna, Juris Zarins, Andris Brazma, Alvis Jackson, Sharon M. Gut, Marta Seywright, Morag Brisuda, Antonin Foglio, Mario Bourque, Guillaume Scelo, Ghislaine Cambon-Thomsen, Anne Tubacher, Emmanuel Mates, Dana Jinga, Viorel Bourgey, Mathieu Artemov, Artem Lathrop, G. Mark Byrnes, Graham Mazur, Alexander Lepage, Pierre Moukeria, Anush Navratilova, Marie Gut, Ivo G. Egevad, Lars Zavadil, Jiri Vasudev, Naveen S. Celms, Edgars How-Kit, Alexandre Bihoreau, Marie-Therese Wozniak, Magdalena B. Holcatova, Ivana Opmanis, Martins Boulygina, Eugenia Greger, Liliana Daunay, Antoine Cartledge, Jon J. Zaridze, David Skryabin, Konstantin Tost, Jörg Foretova, Lenka Brennan, Paul Rastorguev, Sergey Sehmoun, Jeremy Arseneault, Madeleine Nedoluzhko, Artem Blanché, Hélène Su, Jing Prokhortchouk, Egor Letourneau, Louis Karimzadeh, Mehran Carreira, Christine Lechner, Doris Gonzàlez-Porta, Mar Heath, Simon Banks, Rosamonde E. Riazalhosseini, Yasser
Author_xml	– sequence: 1 givenname: Ghislaine surname: Scelo fullname: Scelo, Ghislaine organization: International Agency for Research on Cancer (IARC) – sequence: 2 givenname: Yasser surname: Riazalhosseini fullname: Riazalhosseini, Yasser organization: Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec, Canada H3A 1B1, McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, Quebec, Canada H3A 0G1 – sequence: 3 givenname: Liliana surname: Greger fullname: Greger, Liliana organization: European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus – sequence: 4 givenname: Louis surname: Letourneau fullname: Letourneau, Louis organization: McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, Quebec, Canada H3A 0G1 – sequence: 5 givenname: Mar surname: Gonzàlez-Porta fullname: Gonzàlez-Porta, Mar organization: European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus – sequence: 6 givenname: Magdalena B. surname: Wozniak fullname: Wozniak, Magdalena B. organization: International Agency for Research on Cancer (IARC) – sequence: 7 givenname: Mathieu surname: Bourgey fullname: Bourgey, Mathieu organization: McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, Quebec, Canada H3A 0G1 – sequence: 8 givenname: Patricia surname: Harnden fullname: Harnden, Patricia organization: Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James’s University Hospital – sequence: 9 givenname: Lars surname: Egevad fullname: Egevad, Lars organization: Department of Pathology, Karolinska Institutet – sequence: 10 givenname: Sharon M. surname: Jackson fullname: Jackson, Sharon M. organization: Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James’s University Hospital – sequence: 11 givenname: Mehran surname: Karimzadeh fullname: Karimzadeh, Mehran organization: Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec, Canada H3A 1B1, McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, Quebec, Canada H3A 0G1 – sequence: 12 givenname: Madeleine surname: Arseneault fullname: Arseneault, Madeleine organization: Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec, Canada H3A 1B1, McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, Quebec, Canada H3A 0G1 – sequence: 13 givenname: Pierre surname: Lepage fullname: Lepage, Pierre organization: McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, Quebec, Canada H3A 0G1 – sequence: 14 givenname: Alexandre surname: How-Kit fullname: How-Kit, Alexandre organization: Fondation Jean Dausset - Centre d'Etude du Polymorphisme Humain – sequence: 15 givenname: Antoine surname: Daunay fullname: Daunay, Antoine organization: Fondation Jean Dausset - Centre d'Etude du Polymorphisme Humain – sequence: 16 givenname: Victor surname: Renault fullname: Renault, Victor organization: Fondation Jean Dausset - Centre d'Etude du Polymorphisme Humain – sequence: 17 givenname: Hélène surname: Blanché fullname: Blanché, Hélène organization: Fondation Jean Dausset - Centre d'Etude du Polymorphisme Humain – sequence: 18 givenname: Emmanuel surname: Tubacher fullname: Tubacher, Emmanuel organization: Fondation Jean Dausset - Centre d'Etude du Polymorphisme Humain – sequence: 19 givenname: Jeremy surname: Sehmoun fullname: Sehmoun, Jeremy organization: Fondation Jean Dausset - Centre d'Etude du Polymorphisme Humain – sequence: 20 givenname: Juris surname: Viksna fullname: Viksna, Juris organization: Institute of Mathematics and Computer Science, University of Latvia – sequence: 21 givenname: Edgars surname: Celms fullname: Celms, Edgars organization: Institute of Mathematics and Computer Science, University of Latvia – sequence: 22 givenname: Martins surname: Opmanis fullname: Opmanis, Martins organization: Institute of Mathematics and Computer Science, University of Latvia – sequence: 23 givenname: Andris surname: Zarins fullname: Zarins, Andris organization: Institute of Mathematics and Computer Science, University of Latvia – sequence: 24 givenname: Naveen S. surname: Vasudev fullname: Vasudev, Naveen S. organization: Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James’s University Hospital – sequence: 25 givenname: Morag surname: Seywright fullname: Seywright, Morag organization: Department of Pathology, The Beatson Institute for Cancer Research – sequence: 26 givenname: Behnoush surname: Abedi-Ardekani fullname: Abedi-Ardekani, Behnoush organization: International Agency for Research on Cancer (IARC) – sequence: 27 givenname: Christine surname: Carreira fullname: Carreira, Christine organization: International Agency for Research on Cancer (IARC) – sequence: 28 givenname: Peter J. surname: Selby fullname: Selby, Peter J. organization: Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James’s University Hospital – sequence: 29 givenname: Jon J. surname: Cartledge fullname: Cartledge, Jon J. organization: Pyrah Department of Urology, Leeds Teaching Hospitals NHS Trust, Lincoln Wing, St James’s University Hospital – sequence: 30 givenname: Graham surname: Byrnes fullname: Byrnes, Graham organization: International Agency for Research on Cancer (IARC) – sequence: 31 givenname: Jiri surname: Zavadil fullname: Zavadil, Jiri organization: International Agency for Research on Cancer (IARC) – sequence: 32 givenname: Jing surname: Su fullname: Su, Jing organization: European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus – sequence: 33 givenname: Ivana surname: Holcatova fullname: Holcatova, Ivana organization: First Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University in Prague – sequence: 34 givenname: Antonin surname: Brisuda fullname: Brisuda, Antonin organization: University Hospital Motol – sequence: 35 givenname: David surname: Zaridze fullname: Zaridze, David organization: Russian N.N. Blokhin Cancer Research Centre – sequence: 36 givenname: Anush surname: Moukeria fullname: Moukeria, Anush organization: Russian N.N. Blokhin Cancer Research Centre – sequence: 37 givenname: Lenka surname: Foretova fullname: Foretova, Lenka organization: Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU – sequence: 38 givenname: Marie surname: Navratilova fullname: Navratilova, Marie organization: Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU – sequence: 39 givenname: Dana surname: Mates fullname: Mates, Dana organization: National Institute of Public Health – sequence: 40 givenname: Viorel surname: Jinga fullname: Jinga, Viorel organization: Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital – sequence: 41 givenname: Artem surname: Artemov fullname: Artemov, Artem organization: Centre ‘Bioengineering’, The Russian Academy of Sciences – sequence: 42 givenname: Artem surname: Nedoluzhko fullname: Nedoluzhko, Artem organization: National Research Centre ‘Kurchatov Institute’ – sequence: 43 givenname: Alexander surname: Mazur fullname: Mazur, Alexander organization: Centre ‘Bioengineering’, The Russian Academy of Sciences – sequence: 44 givenname: Sergey surname: Rastorguev fullname: Rastorguev, Sergey organization: National Research Centre ‘Kurchatov Institute’ – sequence: 45 givenname: Eugenia surname: Boulygina fullname: Boulygina, Eugenia organization: National Research Centre ‘Kurchatov Institute’ – sequence: 46 givenname: Simon surname: Heath fullname: Heath, Simon organization: Centro Nacional de Análisis Genómico – sequence: 47 givenname: Marta surname: Gut fullname: Gut, Marta organization: Centro Nacional de Análisis Genómico – sequence: 48 givenname: Marie-Therese surname: Bihoreau fullname: Bihoreau, Marie-Therese organization: Centre National de Génotypage, CEA - Institute de Génomique – sequence: 49 givenname: Doris surname: Lechner fullname: Lechner, Doris organization: Centre National de Génotypage, CEA - Institute de Génomique – sequence: 50 givenname: Mario surname: Foglio fullname: Foglio, Mario organization: Centre National de Génotypage, CEA - Institute de Génomique – sequence: 51 givenname: Ivo G. surname: Gut fullname: Gut, Ivo G. organization: Centro Nacional de Análisis Genómico – sequence: 52 givenname: Konstantin surname: Skryabin fullname: Skryabin, Konstantin organization: Centre ‘Bioengineering’, The Russian Academy of Sciences, National Research Centre ‘Kurchatov Institute’ – sequence: 53 givenname: Egor surname: Prokhortchouk fullname: Prokhortchouk, Egor organization: Centre ‘Bioengineering’, The Russian Academy of Sciences, National Research Centre ‘Kurchatov Institute’ – sequence: 54 givenname: Anne surname: Cambon-Thomsen fullname: Cambon-Thomsen, Anne organization: Faculty of Medicine, Institut National de la Santé et de la Recherche Medicale (INSERM) and University Toulouse III-Paul Sabatier, UMR 1027 – sequence: 55 givenname: Johan surname: Rung fullname: Rung, Johan organization: European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus – sequence: 56 givenname: Guillaume surname: Bourque fullname: Bourque, Guillaume organization: Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec, Canada H3A 1B1, McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, Quebec, Canada H3A 0G1 – sequence: 57 givenname: Paul surname: Brennan fullname: Brennan, Paul organization: International Agency for Research on Cancer (IARC) – sequence: 58 givenname: Jörg surname: Tost fullname: Tost, Jörg organization: Centre National de Génotypage, CEA - Institute de Génomique – sequence: 59 givenname: Rosamonde E. surname: Banks fullname: Banks, Rosamonde E. organization: Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James’s University Hospital – sequence: 60 givenname: Alvis surname: Brazma fullname: Brazma, Alvis organization: European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus – sequence: 61 givenname: G. Mark surname: Lathrop fullname: Lathrop, G. Mark email: tania.abouyounes@mail.mcgill.ca organization: Department of Human Genetics, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec, Canada H3A 1B1, Fondation Jean Dausset - Centre d'Etude du Polymorphisme Humain, Centre National de Génotypage, CEA - Institute de Génomique, Present address: McGill University and Genome Quebec Innovation Centre, 740 Doctor Penfield Avenue, Montreal, Quebec, Canada H3A 0G1
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25351205$$D View this record in MEDLINE/PubMed https://cea.hal.science/cea-04662035$$DView record in HAL http://kipublications.ki.se/Default.aspx?queryparsed=id:130053182$$DView record from Swedish Publication Index
BookMark	eNplkVFvFCEUhYlpY2vtiz_AkPikZisXBpZ5bJpqTTbpS_WV3IU7deoMrLBT47-XddZaUxLCCXz3kHvPC3YQUyTGXoE4A6Hsh-jTOBYDSj9jx1I0sIClVAeP9BE7LeVO1KVasE3znB1JrTRIoY_Z9VfMPW77FHkf-S3FNPaeDxhD8bghnjruB8LMPQ0DzxRxmKXH7PtKI0efUyn8csppQy_ZYYdDodP9ecK-fLy8ubharK4_fb44Xy28VsvtQgZh5BobD5KQWhN0kI0VCFIHJa1R0DY-KLIErbbCSjRou3Vn2yCXujZ-wtrZt_ykzbR2m9yPmH-5hH3VKbj9_fd-t10hB0oIrcDKWvt2rv2Gw3-FV-cr5wmdaIyRQul7qOybma2mPyYqW3eXplynUBwYWFqhGrOj3s3Un1Fk6h5sQbhdTO5fTBV-vbec1iOFB_RvKBV4v--tPsVbyo_-fGr3G9yCnS4
CitedBy_id	crossref_primary_10_1016_j_prp_2023_154940 crossref_primary_10_1038_s41467_019_09241_7 crossref_primary_10_1038_bjc_2015_402 crossref_primary_10_1093_aje_kwaa234 crossref_primary_10_1371_journal_pone_0216135 crossref_primary_10_17650_1726_9776_2019_15_1_23_31 crossref_primary_10_1038_s12276_018_0059_4 crossref_primary_10_1038_s41588_024_01662_5 crossref_primary_10_1002_lci2_14 crossref_primary_10_1097_CCO_0000000000000721 crossref_primary_10_1371_journal_pgen_1007285 crossref_primary_10_18632_aging_202153 crossref_primary_10_1038_nrurol_2015_71 crossref_primary_10_1158_1055_9965_EPI_16_0226 crossref_primary_10_1038_srep44876 crossref_primary_10_1016_j_clgc_2018_01_006 crossref_primary_10_1016_j_tranon_2020_100929 crossref_primary_10_1038_s41467_023_39981_6 crossref_primary_10_1136_jclinpath_2020_206693 crossref_primary_10_21320_2500_2139_2019_12_1_95_100 crossref_primary_10_1038_s41388_017_0084_0 crossref_primary_10_1093_annonc_mdw186 crossref_primary_10_1016_j_dnarep_2016_05_027 crossref_primary_10_1016_j_urolonc_2017_03_015 crossref_primary_10_1093_nar_gkaa371 crossref_primary_10_1002_em_22321 crossref_primary_10_1016_j_ejphar_2019_01_040 crossref_primary_10_1186_s13073_015_0161_3 crossref_primary_10_3310_pgfar06030 crossref_primary_10_1097_MOU_0000000000000516 crossref_primary_10_1089_bio_2018_0036 crossref_primary_10_1093_nar_gky538 crossref_primary_10_3390_ijms18081774 crossref_primary_10_1038_s41392_023_01441_4 crossref_primary_10_1007_s00330_020_07590_2 crossref_primary_10_1371_journal_pone_0176659 crossref_primary_10_1016_j_urolonc_2018_11_006 crossref_primary_10_1158_1055_9965_EPI_16_0219 crossref_primary_10_1371_journal_pgen_1005522 crossref_primary_10_1080_15384101_2015_1006051 crossref_primary_10_1038_srep29267 crossref_primary_10_1039_C5TX00052A crossref_primary_10_2139_ssrn_2772458 crossref_primary_10_1007_s00428_020_02986_3 crossref_primary_10_3389_fphar_2019_00648 crossref_primary_10_1038_s41559_021_01456_6 crossref_primary_10_1016_j_physa_2016_06_089 crossref_primary_10_1097_MOU_0000000000000806 crossref_primary_10_1186_s12859_019_3266_7 crossref_primary_10_1016_j_ejphar_2020_173591 crossref_primary_10_1016_j_mpdhp_2016_01_007 crossref_primary_10_1158_1055_9965_EPI_19_1356 crossref_primary_10_2139_ssrn_2908286 crossref_primary_10_1038_nrneph_2016_133 crossref_primary_10_1038_s41467_023_44159_1 crossref_primary_10_1038_s41588_021_00928_6 crossref_primary_10_1126_scitranslmed_aan6446 crossref_primary_10_1016_j_celrep_2018_04_031 crossref_primary_10_3390_genes12101585 crossref_primary_10_1016_j_pathol_2023_10_016 crossref_primary_10_1038_d41586_024_01190_6 crossref_primary_10_18632_oncotarget_25330 crossref_primary_10_1093_gigascience_giz037 crossref_primary_10_18632_oncotarget_25697 crossref_primary_10_1007_s00204_016_1819_3 crossref_primary_10_1200_JCO_2018_79_1905 crossref_primary_10_1016_j_bbrc_2016_02_008 crossref_primary_10_1016_j_urolonc_2017_10_012 crossref_primary_10_3390_ijms18102144 crossref_primary_10_1093_carcin_bgw045 crossref_primary_10_1101_gr_242453_118 crossref_primary_10_1016_j_semcancer_2018_06_004 crossref_primary_10_3389_fonc_2023_1114461 crossref_primary_10_1056_NEJMra1910138 crossref_primary_10_1007_s00345_018_2429_x crossref_primary_10_1007_s10654_022_00935_9 crossref_primary_10_1038_onc_2016_192 crossref_primary_10_1158_1078_0432_CCR_22_1936 crossref_primary_10_1016_j_euf_2016_06_015 crossref_primary_10_1007_s10555_015_9577_x crossref_primary_10_1097_MOU_0000000000000307 crossref_primary_10_1038_s41571_019_0209_1 crossref_primary_10_1038_s41581_022_00671_z crossref_primary_10_1016_S1470_2045_17_30516_8 crossref_primary_10_1016_j_cell_2018_03_057 crossref_primary_10_1002_1878_0261_13204 crossref_primary_10_1002_1878_0261_12119 crossref_primary_10_1093_carcin_bgv166 crossref_primary_10_1093_jnci_djab204 crossref_primary_10_1016_j_cell_2018_02_020 crossref_primary_10_1016_j_clbc_2024_06_014 crossref_primary_10_1038_s41467_022_29577_x crossref_primary_10_1038_s41418_018_0213_5 crossref_primary_10_1097_CCO_0000000000000418 crossref_primary_10_1177_2042098621997727 crossref_primary_10_1038_s41588_021_00958_0 crossref_primary_10_1002_path_6224 crossref_primary_10_18632_oncotarget_24387 crossref_primary_10_1038_s41586_024_07368_2 crossref_primary_10_1097_MOU_0000000000000204 crossref_primary_10_1248_yakushi_20_00012_1 crossref_primary_10_3390_cancers13225825 crossref_primary_10_1016_j_xgen_2024_100500 crossref_primary_10_1038_s41467_023_37211_7 crossref_primary_10_1016_j_cancergen_2020_04_004 crossref_primary_10_1016_j_eururo_2017_04_032 crossref_primary_10_1080_15592294_2021_1971372 crossref_primary_10_1002_gepi_22558 crossref_primary_10_1093_hmg_ddad079 crossref_primary_10_1177_10668969221145011 crossref_primary_10_1016_j_bbcan_2018_06_003 crossref_primary_10_1038_s41416_020_0874_y crossref_primary_10_1158_1055_9965_EPI_15_0553 crossref_primary_10_1177_87564793231176054 crossref_primary_10_17650_2313_805X_2020_7_3_48_57 crossref_primary_10_1053_j_semdp_2021_11_001 crossref_primary_10_18632_oncotarget_25382 crossref_primary_10_1186_s12864_017_3906_0 crossref_primary_10_1002_path_6072 crossref_primary_10_1016_j_eururo_2023_04_003 crossref_primary_10_18632_oncotarget_17765 crossref_primary_10_1016_j_bdq_2017_07_001 crossref_primary_10_1186_s12982_017_0061_7 crossref_primary_10_1021_acs_chemrestox_3c00333 crossref_primary_10_3390_nu14173581 crossref_primary_10_1371_journal_pone_0164215 crossref_primary_10_1038_s41568_022_00494_x crossref_primary_10_1038_s41598_018_21524_5 crossref_primary_10_1038_s41571_020_0428_5 crossref_primary_10_1038_s41586_019_1670_9 crossref_primary_10_1002_ijc_30845 crossref_primary_10_1200_PO_18_00244 crossref_primary_10_1038_ncomms15724 crossref_primary_10_1016_j_eururo_2016_01_051 crossref_primary_10_4111_icu_20210273 crossref_primary_10_1016_j_cell_2018_03_043 crossref_primary_10_1016_j_jbc_2024_107358 crossref_primary_10_1016_j_jep_2018_07_001 crossref_primary_10_18632_oncotarget_18200 crossref_primary_10_1038_s41598_018_28795_y crossref_primary_10_3389_fonc_2022_990023
Cites_doi	10.1038/ng.723 10.1016/j.humpath.2013.03.009 10.1038/nrclinonc.2013.155 10.1093/bioinformatics/btl646 10.1038/nature08672 10.1038/ng.2682 10.1126/scitranslmed.3006086 10.1038/nature12531 10.1101/gr.121947.111 10.1083/jcb.201102147 10.1038/nbt.1754 10.1038/nrurol.2010.47 10.1038/nmeth.1363 10.1371/journal.pone.0078452 10.1038/nrurol.2010.46 10.1002/med.21286 10.1126/scitranslmed.3006200 10.1038/srep04482 10.1093/hmg/5.2.215 10.1038/ng.2891 10.1186/gb-2013-14-7-r70 10.1093/hmg/ddr479 10.1111/j.1349-7006.2006.00268.x 10.1158/1078-0432.CCR-07-4921 10.1038/ng.2699 10.1073/pnas.0701248104 10.1038/ng.2538 10.1038/nature12477 10.1093/bioinformatics/btp352 10.1093/nar/gks042 10.1038/ncpuro0760 10.1038/ng.2246 10.1038/nmeth.1528 10.1093/bioinformatics/btr670 10.1093/bioinformatics/btp394 10.1126/science.8493574 10.1093/nar/gkp427 10.1158/0008-5472.CAN-05-3074 10.1093/bioinformatics/btq033 10.1242/dmm.004077 10.1038/nature09639 10.1038/nature12222 10.1073/pnas.1009559107 10.1016/j.cell.2009.10.027 10.1056/NEJM200006083422301 10.1038/ki.2008.129 10.1101/gr.133744.111 10.1016/j.ejca.2012.12.027 10.1038/ng.1014 10.1038/nature11273 10.1159/000213081 10.1038/nbt.2778 10.1186/gb-2012-13-8-r77 10.1101/gr.107524.110 10.1371/journal.pcbi.1001138 10.1093/bioinformatics/btp698 10.4161/fly.19695 10.1186/1471-2105-8-52 10.1093/bioinformatics/btr026 10.1093/bioinformatics/btp120 10.1186/gb-2006-7-s1-s12 10.1097/00000478-198210000-00007 10.1093/bioinformatics/16.12.1145 10.1101/gr.134635.111 10.1073/pnas.1221068110 10.1038/nature12912 10.1158/1078-0432.CCR-12-3708 10.1158/1078-0432.CCR-04-2243
ContentType	Journal Article
Copyright	Springer Nature Limited 2014 Copyright Nature Publishing Group Oct 2014 Distributed under a Creative Commons Attribution 4.0 International License
Copyright_xml	– notice: Springer Nature Limited 2014 – notice: Copyright Nature Publishing Group Oct 2014 – notice: Distributed under a Creative Commons Attribution 4.0 International License
DBID	CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7X7 7XB 88E 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABUWG AFKRA ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P5Z P62 P64 PIMPY PQEST PQQKQ PQUKI PRINS RC3 SOI 1XC ADTPV AOWAS
DOI	10.1038/ncomms6135
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central Advanced Technologies & Aerospace Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection ProQuest Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Biological Science Database Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Publicly Available Content Database ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts Environment Abstracts Hyper Article en Ligne (HAL) SwePub SwePub Articles
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management Health Research Premium Collection Natural Science Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Medical Library (Alumni) Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Technology Collection Technology Research Database ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) AIDS and Cancer Research Abstracts ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Immunology Abstracts Environment Abstracts ProQuest Central (Alumni)
DatabaseTitleList	Publicly Available Content Database MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology Public Health
EISSN	2041-1723
ExternalDocumentID	oai_prod_swepub_kib_ki_se_130053182 oai_HAL_cea_04662035v1 3474040531 10_1038_ncomms6135 25351205
Genre	Research Support, Non-U.S. Gov't Journal Article
GeographicLocations	Europe Canada Czech Republic Romania United Kingdom--UK Quebec Canada Montreal Quebec Canada France Russia
GeographicLocations_xml	– name: Europe – name: Quebec Canada – name: Canada – name: Montreal Quebec Canada – name: Romania – name: United Kingdom--UK – name: Czech Republic – name: Russia – name: France
GrantInformation_xml	– fundername: Medical Research Council grantid: MR/L01629X/1 – fundername: Cancer Research UK – fundername: World Health Organization grantid: 001
GroupedDBID	--- 0R~ 39C 3V. 4.4 53G 70F 7X7 88E 8AO 8FE 8FG 8FH 8FI 8FJ AAHBH AAJSJ ABAWZ ABUWG ACGFO ACGFS ACIWK ACMJI ACPRK ACSMW ADBBV ADFRT ADRAZ AENEX AFKRA AFRAH AHMBA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH AOIJS ARAPS ASPBG AVWKF AZFZN BAPOH BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EE. EJD EMOBN F5P FEDTE FYUFA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ LK8 M1P M48 M7P M~E NAO O9- OK1 P2P P62 PIMPY PQQKQ PROAC PSQYO RNS RNT RNTTT RPM SNYQT SV3 TSG UKHRP CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. P64 PQEST PQUKI PRINS RC3 SOI 1XC 5VS ADTPV AOWAS CAG COF KQ8 LGEZI LOTEE NADUK NXXTH
ID	FETCH-LOGICAL-c537t-2d062ba4c12eae96d5d2480a125d32863194cd3e8e1958082a6a8fbf89d275103
IEDL.DBID	M48
ISSN	2041-1723
IngestDate	Sun Oct 13 03:48:50 EDT 2024 Wed Aug 21 06:46:04 EDT 2024 Thu Oct 10 15:51:01 EDT 2024 Fri Aug 23 04:04:53 EDT 2024 Sun Oct 13 10:29:14 EDT 2024 Fri Oct 11 20:37:52 EDT 2024
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Language	English
License	Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c537t-2d062ba4c12eae96d5d2480a125d32863194cd3e8e1958082a6a8fbf89d275103
OpenAccessLink	http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/ncomms6135
PMID	25351205
PQID	1617803461
PQPubID	546298
ParticipantIDs	swepub_primary_oai_prod_swepub_kib_ki_se_130053182 hal_primary_oai_HAL_cea_04662035v1 proquest_journals_1617803461 crossref_primary_10_1038_ncomms6135 pubmed_primary_25351205 springer_journals_10_1038_ncomms6135
PublicationCentury	2000
PublicationDate	10-29-2014
PublicationDateYYYYMMDD	2014-10-29
PublicationDate_xml	– month: 10 year: 2014 text: 10-29-2014 day: 29
PublicationDecade	2010
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	Nature communications
PublicationTitleAbbrev	Nat Commun
PublicationTitleAlternate	Nat Commun
PublicationYear	2014
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	DebelleFDVanherweghemJLNortierJLAristolochic acid nephropathy: a worldwide problemKidney Int.2008741581691:CAS:528:DC%2BD1cXnvVOru7w%3D1841835510.1038/ki.2008.129 Edge, S. et al. AJCC Cancer Staging Manual Springer (2010). LiHDurbinRFast and accurate long-read alignment with Burrows-Wheeler transformBioinformatics20102658959520080505282810810.1093/bioinformatics/btp698 YeKSchulzMHLongQApweilerRNingZPindel: a pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short readsBioinformatics200925286528711:CAS:528:DC%2BD1MXhtlWls7nP19561018278175010.1093/bioinformatics/btp394 MartinGMSomatic mutations are frequent and increase with age in human kidney epithelial cellsHum. Mol. Genet.199652152211:CAS:528:DyaK28XptVCmtg%3D%3D882487710.1093/hmg/5.2.215 GrollmanAPAristolochic acid and the etiology of endemic (Balkan) nephropathyProc. Natl Acad. Sci. USA200710412129121342007PNAS..10412129G1:CAS:528:DC%2BD2sXosVWmtrc%3D1762060710.1073/pnas.07012481041913550 Gonzalez-PortaMCalvoMSammethMGuigoREstimation of alternative splicing variability in human populationsGenome Res.2012225285381:CAS:528:DC%2BC38XjsV2lsbg%3D22113879329078810.1101/gr.121947.111 ApweilerRInterPro--an integrated documentation resource for protein families, domains and functional sitesBioinformatics200016114511501:CAS:528:DC%2BD3MXhtlalu78%3D1115933310.1093/bioinformatics/16.12.1145 ParkJHLeeCSuhJHChaeJYMoonKCNuclear expression of Smad proteins and its prognostic significance in clear cell renal cell carcinomaHum. Pathol.201344204720541:CAS:528:DC%2BC3sXns1KntLY%3D2366899910.1016/j.humpath.2013.03.009 YinTCookDLawrenceMggbio: an R package for extending the grammar of graphics for genomic dataGenome Biol.201213R7722937822405374510.1186/gb-2012-13-8-r77 PolakPReduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repairNat. Biotechnol.20143271751:CAS:528:DC%2BC3sXhvFent7bO2433631810.1038/nbt.2778 AlexandrovLBSignatures of mutational processes in human cancerNature20135004154211:CAS:528:DC%2BC3sXhtlWjur7M23945592377639010.1038/nature12477 The Cancer Genome Atlas Research, N. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature499, 43–49 (2013). McKennaAThe Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing dataGenome Res.201020129713031:CAS:528:DC%2BC3cXhtFeru7jM20644199292850810.1101/gr.107524.110 LinehanWMSrinivasanRSchmidtLSThe genetic basis of kidney cancer: a metabolic diseaseNat. Rev. Urol.201072772851:CAS:528:DC%2BC3cXlslSrtL0%3D20448661292900610.1038/nrurol.2010.47 StefanovicVPolenakovicMFifty years of research in Balkan endemic nephropathy: where are we now?Nephron. Clin. Pract.2009112c51c561:CAS:528:DC%2BD1MXmsFaltL8%3D1939020210.1159/000213081 ZhaoQTumor-specific isoform switch of the fibroblast growth factor receptor 2 underlies the mesenchymal and malignant phenotypes of clear cell renal cell carcinomasClin. Cancer Res.201319246024721:CAS:528:DC%2BC3sXntVWqsrg%3D23444225364402810.1158/1078-0432.CCR-12-3708 LimYPMining the tumor phosphoproteome for cancer markersClin. Cancer Res.200511316331691:CAS:528:DC%2BD2MXjslOqsL0%3D1586720810.1158/1078-0432.CCR-04-2243 DeesNDMuSiC: identifying mutational significance in cancer genomesGenome Res.201222158915981:CAS:528:DC%2BC38XhtFOnsLrE22759861340927210.1101/gr.134635.111 RobinsonJTIntegrative genomics viewerNat. Biotechnol.20112924261:CAS:528:DC%2BC3MXjsFWrtg%3D%3D21221095334618210.1038/nbt.1754 LiHThe Sequence Alignment/Map format and SAMtoolsBioinformatics2009252078207919505943272300210.1093/bioinformatics/btp352 GerlingerMGenomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencingNat. Genet.2014462252331:CAS:528:DC%2BC2cXhs1Sgtrg%3D24487277463605310.1038/ng.2891 NickersonMLImproved identification of von Hippel-Lindau gene alterations in clear cell renal tumorsClin. Cancer Res.200814472647341:CAS:528:DC%2BD1cXpt1ejtrw%3D18676741262966410.1158/1078-0432.CCR-07-4921 WuXA genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23Hum. Mol. Genet.2012214564621:CAS:528:DC%2BC38XmtFem10.1093/hmg/ddr47922010048 VallettiAGenome-wide analysis of differentially expressed genes and splicing isoforms in clear cell renal cell carcinomaPLoS ONE20138e784522013PLoSO...878452V1:CAS:528:DC%2BC3sXhslSjsrrK24194935380682210.1371/journal.pone.0078452 JonesDTRecurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytomaNat. Genet.2013459279321:CAS:528:DC%2BC3sXhtVaktbrI23817572395133610.1038/ng.2682 LawrenceMSDiscovery and saturation analysis of cancer genes across 21 tumour typesNature20145054955012014Natur.505..495L1:CAS:528:DC%2BC2cXhtFOis7w%3D24390350404896210.1038/nature12912 Ferlay, J. et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. (International Agency for Research on Cancer; 2013), Available from http://globocan.iarc.fr, accessed on 5 February (2014). BellmuntJTehBTTortoraGRosenbergJEMolecular targets on the horizon for kidney and urothelial cancerNat. Rev. Clin. Oncol.2013105575701:CAS:528:DC%2BC3sXhsVWqs7nL2398252310.1038/nrclinonc.2013.155 FuhrmanSALaskyLCLimasCPrognostic significance of morphologic parameters in renal cell carcinomaAm. J. Surg. Pathol.198266556631:STN:280:DyaL3s%2FpvVWhtg%3D%3D718096510.1097/00000478-198210000-00007 CoxTRErlerJTRemodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancerDis. Model. Mech.201141651781:CAS:528:DC%2BC3MXktFehsrw%3D21324931304608810.1242/dmm.004077 ChowW-HDongLMDevesaSSEpidemiology and risk factors for kidney cancerNat. Rev. Urol.2010724525720448658301245510.1038/nrurol.2010.46 OlivierMModelling mutational landscapes of human cancers in vitroSci. Rep.20144448224670820525979410.1038/srep04482 HoangMLMutational signature of aristolochic acid exposure as revealed by whole-exome sequencingSci. Transl. Med.20135197ra10223926200397313210.1126/scitranslmed.3006200 LeventalKRMatrix crosslinking forces tumor progression by enhancing integrin signalingCell20091398919061:CAS:528:DC%2BC3cXksFWltQ%3D%3D19931152278800410.1016/j.cell.2009.10.027 Thierry-MiegDThierry-MiegJAceView: a comprehensive cDNA-supported gene and transcripts annotationGenome Biol.20067S12 1S12141692583410.1186/gb-2006-7-s1-s12 AndersSReyesAHuberWDetecting differential usage of exons from RNA-seq dataGenome Res.201222200820171:CAS:528:DC%2BC38XhsVKhsrjN22722343346019510.1101/gr.133744.111 DalglieshGLSystematic sequencing of renal carcinoma reveals inactivation of histone modifying genesNature20104633603632010Natur.463..360D1:CAS:528:DC%2BC3cXhvFeqtw%3D%3D20054297282024210.1038/nature08672 TomasettiCVogelsteinBParmigianiGHalf or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiationProc. Natl Acad. Sci. USA2013110199920042013PNAS..110.1999T1:CAS:528:DC%2BC3sXjtVSks7w%3D2334542210.1073/pnas.12210681103568331 SchmiederREdwardsRQuality control and preprocessing of metagenomic datasetsBioinformatics2011278638641:CAS:528:DC%2BC3MXjt1Sksrg%3D21278185305132710.1093/bioinformatics/btr026 KatzYWangETAiroldiEMBurgeCBAnalysis and design of RNA sequencing experiments for identifying isoform regulationNat. Methods20107100910151:CAS:528:DC%2BC3cXhtl2jtrzE21057496303702310.1038/nmeth.1528 SceloGBrennanPThe epidemiology of bladder and kidney cancerNat. Clin. Pract. Urol.200742052171741535310.1038/ncpuro0760 SatoYIntegrated molecular analysis of clear-cell renal cell carcinomaNat. Genet.2013458608671:CAS:528:DC%2BC3sXpvFCiuro%3D2379773610.1038/ng.2699 VarelaIExome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinomaNature20114695395422011Natur.469..539V1:CAS:528:DC%2BC3MXnsFaquw%3D%3D21248752303092010.1038/nature09639 MorrisLGRecurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activationNat. Genet.2013452532611:CAS:528:DC%2BC3sXhsVaqsb8%3D23354438372904010.1038/ng.2538 ChenJBardesEEAronowBJJeggaAGToppGene Suite for gene list enrichment analysis and candidate gene prioritizationNucleic Acids Res.200937W305W3111:CAS:528:DC%2BD1MXosFSrs7g%3D19465376270397810.1093/nar/gkp427 PurdueMPGenome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3Nat. Genet.20114360651:CAS:528:DC%2BC3cXhsFajurbO10.1038/ng.72321131975 QuinlanARHallIMBEDTools: a flexible suite of utilities for comparing genomic featuresBioinformatics2010268418421:CAS:528:DC%2BC3cXivFGkurc%3D20110278283282410.1093/bioinformatics/btq033 Gonzalez-PortaMFrankishARungJHarrowJBrazmaATranscriptome analysis of human tissues and cell lines reveals one dominant transcript per geneGenome Biol.201314R7023815980405375410.1186/gb-2013-14-7-r70 ZangZJExome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genesNat. Genet.2012445705741:CAS:528:DC%2BC38XltFOnt74%3D2248462810.1038/ng.2246 ChenKBreakDancer: an algorithm for high-resolution mapping of genomic structural variationNat. Methods200966776811:CAS:528:DC%2BD1MXps1agsrs%3D19668202366177510.1038/nmeth.1363 McCarthyDJChenYSmythGKDifferential expression analysis of multifactor RNA-Seq experiments with respect to biological variationNucleic Acids Res.201240428842971:CAS:528:DC%2BC38XnsF2ks74%3D22287627337888210.1093/nar/gks042 GuoGFrequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinomaNat. Genet.20124417191:CAS:528:DC%2BC3MXhsFGkurzL10.1038/ng.1014 LuPWeaverVMWerbZThe extracellular matrix: a dynamic niche in cancer progressionJ. Cell Biol.20121963954061:CAS:528:DC%2BC38XjtV2hsLk%3D22351925328399310.1083/jcb.201102147 MikamiSExpression of Ets-1 in human clear cell renal cell carcinomas: implications for angiogenesisCancer Sci.2006978758821:CAS:528:DC%2BD28XpsFelsLs%3D1685688010.1111/j.1349-7006.2006.00268.x McPhersonAdeFuse: an algorithm for gene C Tomasetti (BFncomms6135_CR33) 2013; 110 W-H Chow (BFncomms6135_CR2) 2010; 7 GM Martin (BFncomms6135_CR32) 1996; 5 Y Sato (BFncomms6135_CR19) 2013; 45 SL Poon (BFncomms6135_CR27) 2013; 5 P Cingolani (BFncomms6135_CR52) 2012; 6 X Wu (BFncomms6135_CR6) 2012; 21 ZJ Zang (BFncomms6135_CR43) 2012; 44 G Scelo (BFncomms6135_CR9) 2007; 4 BFncomms6135_CR20 JT Robinson (BFncomms6135_CR53) 2011; 29 YP Lim (BFncomms6135_CR25) 2005; 11 AP Grollman (BFncomms6135_CR13) 2007; 104 P Lu (BFncomms6135_CR40) 2012; 196 K Chen (BFncomms6135_CR56) 2009; 6 M Gerlinger (BFncomms6135_CR36) 2014; 46 J Chen (BFncomms6135_CR69) 2009; 37 AE Burrows (BFncomms6135_CR35) 2010; 107 V Boeva (BFncomms6135_CR55) 2012; 28 R Schmieder (BFncomms6135_CR59) 2011; 27 A Valletti (BFncomms6135_CR44) 2013; 8 WM Linehan (BFncomms6135_CR26) 2010; 7 S Mikami (BFncomms6135_CR23) 2006; 97 A McPherson (BFncomms6135_CR65) 2011; 7 ND Dees (BFncomms6135_CR17) 2012; 22 Q Zhao (BFncomms6135_CR45) 2013; 19 J Bellmunt (BFncomms6135_CR8) 2013; 10 S Anders (BFncomms6135_CR62) 2012; 22 JH Park (BFncomms6135_CR24) 2013; 44 LG Morris (BFncomms6135_CR42) 2013; 45 F Latif (BFncomms6135_CR5) 1993; 260 T Lappalainen (BFncomms6135_CR66) 2013; 501 Y Sato (BFncomms6135_CR46) 2013; 45 T Yin (BFncomms6135_CR70) 2012; 13 LB Alexandrov (BFncomms6135_CR16) 2013; 500 M Olivier (BFncomms6135_CR28) 2014; 4 KR Levental (BFncomms6135_CR39) 2009; 139 cr-split#-BFncomms6135_CR1.2 cr-split#-BFncomms6135_CR1.1 D Thierry-Mieg (BFncomms6135_CR67) 2006; 7 I Varela (BFncomms6135_CR34) 2011; 469 BFncomms6135_CR48 AR Quinlan (BFncomms6135_CR58) 2010; 26 R Apweiler (BFncomms6135_CR68) 2000; 16 ES Venkatraman (BFncomms6135_CR54) 2007; 23 RE Banks (BFncomms6135_CR3) 2006; 66 M Gonzalez-Porta (BFncomms6135_CR22) 2013; 14 E Sadeqzadeh (BFncomms6135_CR41) 2014; 34 ML Hoang (BFncomms6135_CR12) 2013; 5 P Polak (BFncomms6135_CR11) 2014; 32 JL Nortier (BFncomms6135_CR14) 2000; 342 G Guo (BFncomms6135_CR18) 2012; 44 DJ McCarthy (BFncomms6135_CR61) 2012; 40 GL Dalgliesh (BFncomms6135_CR21) 2010; 463 MP Purdue (BFncomms6135_CR7) 2011; 43 H Li (BFncomms6135_CR51) 2009; 25 C Trapnell (BFncomms6135_CR60) 2009; 25 J Ferlay (BFncomms6135_CR29) 2013; 49 V Stefanovic (BFncomms6135_CR31) 2009; 112 J Viksna (BFncomms6135_CR71) 2007; 8 H Li (BFncomms6135_CR49) 2010; 26 ML Nickerson (BFncomms6135_CR4) 2008; 14 K Ye (BFncomms6135_CR57) 2009; 25 M Gonzalez-Porta (BFncomms6135_CR64) 2012; 22 B Schuster-Bockler (BFncomms6135_CR10) 2012; 488 FD Debelle (BFncomms6135_CR30) 2008; 74 TR Cox (BFncomms6135_CR38) 2011; 4 DT Jones (BFncomms6135_CR15) 2013; 45 SA Fuhrman (BFncomms6135_CR47) 1982; 6 Y Katz (BFncomms6135_CR63) 2010; 7 MS Lawrence (BFncomms6135_CR37) 2014; 505 A McKenna (BFncomms6135_CR50) 2010; 20
References_xml	– volume: 43 start-page: 60 year: 2011 ident: BFncomms6135_CR7 publication-title: Nat. Genet. doi: 10.1038/ng.723 contributor: fullname: MP Purdue – volume: 44 start-page: 2047 year: 2013 ident: BFncomms6135_CR24 publication-title: Hum. Pathol. doi: 10.1016/j.humpath.2013.03.009 contributor: fullname: JH Park – volume: 10 start-page: 557 year: 2013 ident: BFncomms6135_CR8 publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/nrclinonc.2013.155 contributor: fullname: J Bellmunt – volume: 23 start-page: 657 year: 2007 ident: BFncomms6135_CR54 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btl646 contributor: fullname: ES Venkatraman – volume: 463 start-page: 360 year: 2010 ident: BFncomms6135_CR21 publication-title: Nature doi: 10.1038/nature08672 contributor: fullname: GL Dalgliesh – volume: 45 start-page: 927 year: 2013 ident: BFncomms6135_CR15 publication-title: Nat. Genet. doi: 10.1038/ng.2682 contributor: fullname: DT Jones – volume: 5 start-page: 197ra101 year: 2013 ident: BFncomms6135_CR27 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3006086 contributor: fullname: SL Poon – volume: 501 start-page: 506 year: 2013 ident: BFncomms6135_CR66 publication-title: Nature doi: 10.1038/nature12531 contributor: fullname: T Lappalainen – volume: 22 start-page: 528 year: 2012 ident: BFncomms6135_CR64 publication-title: Genome Res. doi: 10.1101/gr.121947.111 contributor: fullname: M Gonzalez-Porta – volume: 196 start-page: 395 year: 2012 ident: BFncomms6135_CR40 publication-title: J. Cell Biol. doi: 10.1083/jcb.201102147 contributor: fullname: P Lu – volume: 29 start-page: 24 year: 2011 ident: BFncomms6135_CR53 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1754 contributor: fullname: JT Robinson – volume: 7 start-page: 277 year: 2010 ident: BFncomms6135_CR26 publication-title: Nat. Rev. Urol. doi: 10.1038/nrurol.2010.47 contributor: fullname: WM Linehan – ident: BFncomms6135_CR48 – volume: 6 start-page: 677 year: 2009 ident: BFncomms6135_CR56 publication-title: Nat. Methods doi: 10.1038/nmeth.1363 contributor: fullname: K Chen – volume: 8 start-page: e78452 year: 2013 ident: BFncomms6135_CR44 publication-title: PLoS ONE doi: 10.1371/journal.pone.0078452 contributor: fullname: A Valletti – volume: 7 start-page: 245 year: 2010 ident: BFncomms6135_CR2 publication-title: Nat. Rev. Urol. doi: 10.1038/nrurol.2010.46 contributor: fullname: W-H Chow – volume: 34 start-page: 190 year: 2014 ident: BFncomms6135_CR41 publication-title: Med. Res. Rev. doi: 10.1002/med.21286 contributor: fullname: E Sadeqzadeh – volume: 5 start-page: 197ra102 year: 2013 ident: BFncomms6135_CR12 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3006200 contributor: fullname: ML Hoang – volume: 4 start-page: 4482 year: 2014 ident: BFncomms6135_CR28 publication-title: Sci. Rep. doi: 10.1038/srep04482 contributor: fullname: M Olivier – volume: 5 start-page: 215 year: 1996 ident: BFncomms6135_CR32 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/5.2.215 contributor: fullname: GM Martin – volume: 46 start-page: 225 year: 2014 ident: BFncomms6135_CR36 publication-title: Nat. Genet. doi: 10.1038/ng.2891 contributor: fullname: M Gerlinger – volume: 14 start-page: R70 year: 2013 ident: BFncomms6135_CR22 publication-title: Genome Biol. doi: 10.1186/gb-2013-14-7-r70 contributor: fullname: M Gonzalez-Porta – volume: 21 start-page: 456 year: 2012 ident: BFncomms6135_CR6 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddr479 contributor: fullname: X Wu – volume: 97 start-page: 875 year: 2006 ident: BFncomms6135_CR23 publication-title: Cancer Sci. doi: 10.1111/j.1349-7006.2006.00268.x contributor: fullname: S Mikami – volume: 14 start-page: 4726 year: 2008 ident: BFncomms6135_CR4 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-07-4921 contributor: fullname: ML Nickerson – volume: 45 start-page: 860 year: 2013 ident: BFncomms6135_CR19 publication-title: Nat. Genet. doi: 10.1038/ng.2699 contributor: fullname: Y Sato – volume: 104 start-page: 12129 year: 2007 ident: BFncomms6135_CR13 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0701248104 contributor: fullname: AP Grollman – volume: 45 start-page: 253 year: 2013 ident: BFncomms6135_CR42 publication-title: Nat. Genet. doi: 10.1038/ng.2538 contributor: fullname: LG Morris – ident: #cr-split#-BFncomms6135_CR1.2 – volume: 500 start-page: 415 year: 2013 ident: BFncomms6135_CR16 publication-title: Nature doi: 10.1038/nature12477 contributor: fullname: LB Alexandrov – volume: 25 start-page: 2078 year: 2009 ident: BFncomms6135_CR51 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp352 contributor: fullname: H Li – volume: 40 start-page: 4288 year: 2012 ident: BFncomms6135_CR61 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gks042 contributor: fullname: DJ McCarthy – volume: 4 start-page: 205 year: 2007 ident: BFncomms6135_CR9 publication-title: Nat. Clin. Pract. Urol. doi: 10.1038/ncpuro0760 contributor: fullname: G Scelo – volume: 44 start-page: 570 year: 2012 ident: BFncomms6135_CR43 publication-title: Nat. Genet. doi: 10.1038/ng.2246 contributor: fullname: ZJ Zang – volume: 7 start-page: 1009 year: 2010 ident: BFncomms6135_CR63 publication-title: Nat. Methods doi: 10.1038/nmeth.1528 contributor: fullname: Y Katz – volume: 28 start-page: 423 year: 2012 ident: BFncomms6135_CR55 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr670 contributor: fullname: V Boeva – volume: 25 start-page: 2865 year: 2009 ident: BFncomms6135_CR57 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp394 contributor: fullname: K Ye – volume: 260 start-page: 1317 year: 1993 ident: BFncomms6135_CR5 publication-title: Science doi: 10.1126/science.8493574 contributor: fullname: F Latif – volume: 37 start-page: W305 year: 2009 ident: BFncomms6135_CR69 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkp427 contributor: fullname: J Chen – volume: 66 start-page: 2000 year: 2006 ident: BFncomms6135_CR3 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-05-3074 contributor: fullname: RE Banks – volume: 26 start-page: 841 year: 2010 ident: BFncomms6135_CR58 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq033 contributor: fullname: AR Quinlan – volume: 4 start-page: 165 year: 2011 ident: BFncomms6135_CR38 publication-title: Dis. Model. Mech. doi: 10.1242/dmm.004077 contributor: fullname: TR Cox – volume: 469 start-page: 539 year: 2011 ident: BFncomms6135_CR34 publication-title: Nature doi: 10.1038/nature09639 contributor: fullname: I Varela – ident: BFncomms6135_CR20 doi: 10.1038/nature12222 – volume: 107 start-page: 14280 year: 2010 ident: BFncomms6135_CR35 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1009559107 contributor: fullname: AE Burrows – volume: 139 start-page: 891 year: 2009 ident: BFncomms6135_CR39 publication-title: Cell doi: 10.1016/j.cell.2009.10.027 contributor: fullname: KR Levental – volume: 342 start-page: 1686 year: 2000 ident: BFncomms6135_CR14 publication-title: New Engl. J. Med. doi: 10.1056/NEJM200006083422301 contributor: fullname: JL Nortier – volume: 74 start-page: 158 year: 2008 ident: BFncomms6135_CR30 publication-title: Kidney Int. doi: 10.1038/ki.2008.129 contributor: fullname: FD Debelle – volume: 22 start-page: 2008 year: 2012 ident: BFncomms6135_CR62 publication-title: Genome Res. doi: 10.1101/gr.133744.111 contributor: fullname: S Anders – ident: #cr-split#-BFncomms6135_CR1.1 – volume: 49 start-page: 1374 year: 2013 ident: BFncomms6135_CR29 publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2012.12.027 contributor: fullname: J Ferlay – volume: 44 start-page: 17 year: 2012 ident: BFncomms6135_CR18 publication-title: Nat. Genet. doi: 10.1038/ng.1014 contributor: fullname: G Guo – volume: 488 start-page: 504 year: 2012 ident: BFncomms6135_CR10 publication-title: Nature doi: 10.1038/nature11273 contributor: fullname: B Schuster-Bockler – volume: 112 start-page: c51 year: 2009 ident: BFncomms6135_CR31 publication-title: Nephron. Clin. Pract. doi: 10.1159/000213081 contributor: fullname: V Stefanovic – volume: 32 start-page: 71 year: 2014 ident: BFncomms6135_CR11 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2778 contributor: fullname: P Polak – volume: 13 start-page: R77 year: 2012 ident: BFncomms6135_CR70 publication-title: Genome Biol. doi: 10.1186/gb-2012-13-8-r77 contributor: fullname: T Yin – volume: 45 start-page: 860 year: 2013 ident: BFncomms6135_CR46 publication-title: Nat. Genet. doi: 10.1038/ng.2699 contributor: fullname: Y Sato – volume: 20 start-page: 1297 year: 2010 ident: BFncomms6135_CR50 publication-title: Genome Res. doi: 10.1101/gr.107524.110 contributor: fullname: A McKenna – volume: 7 start-page: e1001138 year: 2011 ident: BFncomms6135_CR65 publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1001138 contributor: fullname: A McPherson – volume: 26 start-page: 589 year: 2010 ident: BFncomms6135_CR49 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp698 contributor: fullname: H Li – volume: 6 start-page: 80 year: 2012 ident: BFncomms6135_CR52 publication-title: Fly (Austin) doi: 10.4161/fly.19695 contributor: fullname: P Cingolani – volume: 8 start-page: 52 year: 2007 ident: BFncomms6135_CR71 publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-8-52 contributor: fullname: J Viksna – volume: 27 start-page: 863 year: 2011 ident: BFncomms6135_CR59 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr026 contributor: fullname: R Schmieder – volume: 25 start-page: 1105 year: 2009 ident: BFncomms6135_CR60 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp120 contributor: fullname: C Trapnell – volume: 7 start-page: S12 1 year: 2006 ident: BFncomms6135_CR67 publication-title: Genome Biol. doi: 10.1186/gb-2006-7-s1-s12 contributor: fullname: D Thierry-Mieg – volume: 6 start-page: 655 year: 1982 ident: BFncomms6135_CR47 publication-title: Am. J. Surg. Pathol. doi: 10.1097/00000478-198210000-00007 contributor: fullname: SA Fuhrman – volume: 16 start-page: 1145 year: 2000 ident: BFncomms6135_CR68 publication-title: Bioinformatics doi: 10.1093/bioinformatics/16.12.1145 contributor: fullname: R Apweiler – volume: 22 start-page: 1589 year: 2012 ident: BFncomms6135_CR17 publication-title: Genome Res. doi: 10.1101/gr.134635.111 contributor: fullname: ND Dees – volume: 110 start-page: 1999 year: 2013 ident: BFncomms6135_CR33 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1221068110 contributor: fullname: C Tomasetti – volume: 505 start-page: 495 year: 2014 ident: BFncomms6135_CR37 publication-title: Nature doi: 10.1038/nature12912 contributor: fullname: MS Lawrence – volume: 19 start-page: 2460 year: 2013 ident: BFncomms6135_CR45 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-12-3708 contributor: fullname: Q Zhao – volume: 11 start-page: 3163 year: 2005 ident: BFncomms6135_CR25 publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-04-2243 contributor: fullname: YP Lim
SSID	ssj0000391844
Score	2.564889
Snippet	The incidence of renal cell carcinoma (RCC) is increasing worldwide, and its prevalence is particularly high in some parts of Central Europe. Here we undertake...
SourceID	swepub hal proquest crossref pubmed springer
SourceType	Open Access Repository Aggregation Database Index Database Publisher
StartPage	5135
SubjectTerms	631/208/69 631/67/2324 631/67/589/1588/1351 Adult Aged Aged, 80 and over Biochemistry, Molecular Biology Cancer research Carcinoma, Renal Cell - genetics Cohort Studies Epidemiology Epigenetics Europe Female Focal Adhesions - metabolism Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic Variation Genome, Human - genetics Genomes Genomics Hospitals Humanities and Social Sciences Humans Kidney cancer Life Sciences Male Medical research Medicin och hälsovetenskap Middle Aged multidisciplinary Mutation Mutation Rate Oncogene Proteins, Fusion - genetics Pathology Phosphatidylinositol 3-Kinases - genetics Public health RNA Splicing - genetics Science Science (multidisciplinary) Sequence Analysis, DNA Signal Transduction - genetics
SummonAdditionalLinks	– databaseName: ProQuest Technology Collection dbid: 8FG link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fSxwxEB6qpSBIaa3aa20J1tfF3fy65KlI6fUoRV-0-BaySRZF3LPeKfjfdya7e2otPiwsu9lhyGwyX2aSbwD2GoXqRaULoVIqZNS-sKrxRTRNHAeLXiPmXb6Henoif56q0z7gNu-3VQ5zYp6o4yxQjHyfcLgphdTV16s_BVWNouxqX0JjBV5WxIRHJ8UnP5YxFmI_N1IOrKTC7Lco8nKOLkw98kMrZ7QL8inEfJAe_YdKNLufyRt43eNGdtAZ-i28SO0GvOoqSd5twHoXfmPdqaJ3cPQb18C509l5y4iI9RLf5nO9tOOJzRoWqGAEo8A9u04kO98Gqi2ErT3zWXHWhes34WTy_fjbtOhrJxRBifGi4LHUvPYyVDz5ZHVUkUtTesQzUXCjceTJEEUyidhmEAd47U1TN8ZGPiaWvS1YbWdteg9sXHsdOK-rxtQSW_tgbS1SaGyN4MvbEXwZetJddRQZLqe2hXH3_T2CXezkZQNitZ4e_HIheYdLdM1LoW6rEewMNnD9WJq7e8uPYLuzy1IMVwIRS4nS9wZDPfjwP0rwzoiP9CBX5frnF-d0uXnKeT6coAz_8LxSH2ENQZQkf8btDqwurm_SJwQqi_pz_hv_AuXH6OU priority: 102 providerName: ProQuest – databaseName: SpringerOpen dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3dS8MwEA9OEXwRv51OCbrXYpuvJY8yHENEX5zsLaRJikNWxU3B_95L2uqmPvhQKG16HHdJ75dc8juEugUH9RwXCeXeJ8wJkyhemMTJwvWsgqjh4i7fWzEcsesxH6-gs-YszFL-nsqLEuw-nUHM4S20xjORhp7bF_2vdZTAcC4Za5hHlz5ZijWtx7DT8TeMXEiB_qALjSFmsIU2a2yILytnbqMVX-6g9apa5McuunuAeW00JJ6UOJCrTicWx7O6YRcTfi6wDUUgcFiMx68-yIq3NtQLgtYGm6gorpbg99BocHXfHyZ1PYTEctqbJ8SlguSG2Yx445Vw3BEmUwMYxVEiBYwmZh310gcGGYjtRhhZ5IVUjvQCc94-Wi2fS3-IcC83whKSZ4XMGbQ2VqmceluoHACVUW103lhOv1S0Fzqmq6nU3_Ztg99gODQNAlP18PJGW280TLsFSSl_z9qo09hc1-NjpsOsSqaUCXh9UPnhSwzhFFBICtK7jWMWPvxDCVI5bUmPEH50_fxpEi498zF3Bz8dSY7-J_sYbQBAYiFWEdVBq_PXN38CIGSen8Ze-AkWh9tU priority: 102 providerName: Springer Nature
Title	Variation in genomic landscape of clear cell renal cell carcinoma across Europe
URI	https://link.springer.com/article/10.1038/ncomms6135 https://www.ncbi.nlm.nih.gov/pubmed/25351205 https://www.proquest.com/docview/1617803461 https://cea.hal.science/cea-04662035 http://kipublications.ki.se/Default.aspx?queryparsed=id:130053182
Volume	5
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED-tm5B4QXyvbFQW7DWQ-iv2A0KlWqkqGAgo6pvl2I6oYBlrC2L_PWcnGSvsiYd8yLGt052d-53PvgM4qgSS54XMmAgh417aTIvKZl5VvnAatYZPu3xP5HTOZwux2IEuf2fLwPW1pl3MJzVffXv26_ziJU74F82RcfW8RtmcrlEviR7sUc54HOlvW5if_shMoyETHcw058MMdTbrIpVuNd_STb0vcWfkv7Dzisv0r_CiSSVNbsOtFkuSUSP8O7AT6rtwo8kueXEP3n1GOzgxnixrEoOxni4dSWd7464nclYRF5NGkLh4T1Yh9pVeXcwvhLUtsYlQ0izZ34f55PjTeJq1-RMyJ1ixyajPJS0td0MabNDSC0-5yi1iGs-okjj7uPMsqBAjziAWsNKqqqyU9rSIkfYewG59Vod9IEVppaO0HFaq5FjbOq1LFlylSwRgVvfhacc5870Jk2GSe5sp84e_fXiCTL2sECNbT0dvjAvWoJkuac7Ez2EfDjuem244mGiFqRwli58fNnK47IYKhqglx96POsFcaXgNEbQR2hYdUV2ZtvzrMl5mHZKvD39Sij76n0YHcBPhFY-ajupD2N2sfoTHCGE25QB6xaLAu5q8HsDeaDT7OMPnq-OT9x-wdCzHgzSCfwMfVvdv
link.rule.ids	230,315,786,790,891,12083,12792,21416,24346,27955,27956,31752,33406,33777,41153,42222,43343,43633,43838,51609,74100,74390,74657
linkProvider	Scholars Portal
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3daxQxEB_sFVGQovXrbNWgfV26l69LnqQtLaeep0grfQvZJItFuld7p-B_70x299qq-LCw7GaHYWaT-WWS_AZgp1aoXlS6ECqlQkbtC6tqX0RTx3GwGDVi3uU705MT-e5UnXYJt0W3rbIfE_NAHeeBcuS7hMNNKaQevbn4XlDVKFpd7UporME6UW6aAazvH84-fV5lWYj_3EjZ85IKs9ug0PMFBjF1IxKtfaV9kH-DzGsLpH-QieYAdHQfNjrkyPZaVz-AW6nZhNttLclfm3CvTcCx9lzRQ_j4BWfB2ezsrGFExXqOb_PJXtrzxOY1C1QyglHqnl0mkp1vA1UXwtae-aw4axP2j-Dk6PD4YFJ01ROKoMR4WfBYal55GUY8-WR1VJFLU3pENFFwo7HvyRBFMon4ZhAJeO1NXdXGRj4mnr3HMGjmTXoKbFx5HTivRrWpJLb2wdpKpFDbCuGXt0N43VvSXbQkGS4vbgvjruw9hFdo5FUD4rWe7E1dSN7hJF3zUqifoyFs9z5wXW9auCvfD-FJ65eVGK4EYpYSpe_0jrr24T-U4K0Tb-hBwcp1z7-d0eUWKa_04RBl-LP_K_US7kyOP0zd9O3s_RbcRUglKbpxuw2D5eWP9Bxhy7J60f2bvwH7WO08
linkToPdf	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3daxQxEB9sRSmIaP06rRq0r8vt5euSJynqeWqpPljpW8jmA4t0r-2dgv-9M9nda6viw8Kymw1DJpv5ZWbyG4DdrFC8qHQlVEqVjNpXVmVfRZPjNFi0GrFk-R7o-aH8cKSO-vynZZ9WOayJZaGOi0A-8jHhcFMLqSfj3KdFfH4ze3V6VlEFKYq09uU0NuA6gWwq42Bm79b-FmJCN1IODKXCjFvs_mSJ5kxdsUkb3ygj8m-4eSlU-getaDFFsztwu8eQbK9T-l24ltptuNFVlfy1Dbc6VxzrThjdg09fcT9cFMCOW0akrCf4tpzxpewntsgsUPEIRk58dp6o73IbqM4QtvbMF8FZ57q_D4ezt19ez6u-jkIVlJiuKh5rzRsvw4Qnn6yOKnJpao_YJgpuNP6FMkSRTCLmGcQEXnuTm2xs5FNi3HsAm-2iTY-ATRuvA-fNJJtGYmsfrG1ECtk2CMS8HcHLYSTdaUeX4UqYWxh3Md4jeIGDvG5ADNfzvX0Xkne4Xde8FurnZAQ7gw5c_18t3cUsGMHDTi_rbrgSiF5q7H13UNSlD_8hBO-UeEUOMluuf_79mC63TCXmh4uV4Y__L9RzuImT0u2_P_j4BLYQW0kyc9zuwObq_Ed6ivhl1TwrE_M34k_wAg
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Variation+in+genomic+landscape+of+clear+cell+renal+cell+carcinoma+across+Europe&rft.jtitle=Nature+communications&rft.au=Scelo%2C+G&rft.au=Riazalhosseini%2C+Y&rft.au=Greger%2C+L&rft.au=Letourneau%2C+L&rft.date=2014-10-29&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=5&rft.spage=5135&rft_id=info:doi/10.1038%2Fncomms6135&rft.externalDocID=oai_prod_swepub_kib_ki_se_130053182
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon