Superiority of Directly Administered Antiretroviral Therapy over Self-Administered Therapy among HIV-Infected Drug Users: A Prospective, Randomized, Controlled Trial

• Published in: Clinical infectious diseases Vol. 45; no. 6; pp. 770 - 778
• Main Authors: Altice, Frederick L., Maru, Duncan Smith-Rohrberg, Bruce, R. Douglas, Springer, Sandra A., Friedland, Gerald H.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University Chicago Press 15.09.2007; University of Chicago Press; Oxford University Press
• Subjects: Adult; AIDS; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiretroviral drugs; Antiretroviral Therapy, Highly Active; Antiretrovirals; Antiviral agents; Antivirals; Biological and medical sciences; Clinical outcomes; Directly Observed Therapy - methods; Drug addictions; Drug therapy; Female; Health outcomes; HIV; HIV 1; HIV Infections - complications; HIV Infections - drug therapy; HIV-1 - drug effects; HIV-1 - genetics; HIV/AIDS; Human immunodeficiency virus; Human immunodeficiency virus 1; Human viral diseases; Humans; Infectious diseases; Kaplan-Meier Estimate; Male; Medical sciences; Middle Aged; Patient Compliance - statistics & numerical data; Pharmacology. Drug treatments; Prospective Studies; RNA; RNA, Viral - genetics; RNA, Viral - metabolism; Self Administration - methods; Substance-Related Disorders - complications; T lymphocytes; Toxicology; Treatment Outcome; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral load; Virology; Infection; Human; Immunopathology; Drug addiction; Antiretroviral agent; Chemotherapy; Treatment; Viral disease; Antiviral; AIDS; Immune deficiency

Background. Directly administered antiretroviral therapy (DAART) is one approach to improve treatment adherence among human immunodeficiency virus (HIV)—infected drug users. Methods. In this randomized, controlled trial (ClinicalTrials.gov identifier, NCT00367172), the biological outcomes of a 6-mon...