Mechanisms and consequences of widespread random monoallelic expression

• Published in: Nature reviews. Genetics Vol. 13; no. 6; pp. 421 - 428
• Main Author: Chess, Andrew
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2012; Nature Publishing Group
• Subjects: 631/208/200; Agriculture; Alleles; Animal Genetics and Genomics; Animals; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cloning; Evolution; Evolution, Molecular; Female; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation; Gene Function; Genetics of eukaryotes. Biological and molecular evolution; Genomes; Human Genetics; Humans; Immune system; Models, Genetic; Ontology; Physiological aspects; review-article; Selection, Genetic; X chromosome; X Chromosome Inactivation - genetics; United States; New York; United States > US; Mechanism; Review

Key Points Monoallelic expression is an interesting epigenetic phenomenon, as it requires cells to treat the two alleles of a gene unequally, even though their sequences can be identical and they are present in the same nucleus. Although monoallelic expression in the context of genomic imprinting is...