Deconstructing the Peptide-MHC Specificity of T Cell Recognition

• Published in: Cell Vol. 157; no. 5; pp. 1073 - 1087
• Main Authors: Birnbaum, Michael E., Mendoza, Juan L., Sethi, Dhruv K., Dong, Shen, Glanville, Jacob, Dobbins, Jessica, Özkan, Engin, Davis, Mark M., Wucherpfennig, Kai W., Garcia, K. Christopher
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.05.2014
• Subjects: Algorithms; Amino Acid Sequence; Animals; Cross Reactions; High-Throughput Nucleotide Sequencing; HLA Antigens - immunology; HLA Antigens - metabolism; Humans; Ligands; Mice; Models, Molecular; Peptide Library; Peptides - chemistry; Peptides - immunology; Receptors, Antigen, T-Cell - chemistry; Receptors, Antigen, T-Cell - immunology; T-Lymphocytes - chemistry; T-Lymphocytes - immunology

In order to survey a universe of major histocompatibility complex (MHC)-presented peptide antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors (TCRs) are thought to be cross-reactive. However, the nature and extent of TCR cross-reactivity has not been conclu...