Approaches to quantify radioligands that wash out slowly from target organs

As a general approach to radioligands with slow kinetics, studies in animals should be used to determine key pharmacological properties, like reversibility, of the radio-ligand; that long scans (and sometimes atypically long scans) be used to identify slow rate constants; and that retest studies can...

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Published inEuropean journal of nuclear medicine and molecular imaging Vol. 37; no. 5; pp. 917 - 919
Main Authors Hirvonen, Jussi, Terry, Garth E., Halldin, Christer, Pike, Victor W., Innis, Robert B.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.05.2010
Springer Nature B.V
Subjects
Animals
Brain
Brain - metabolism
Cardiology
Editorial Commentary
Humans
Imaging
Kinetics
Ligands
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Orthopedics
Radiology
Radiopharmaceuticals - analysis
Radiopharmaceuticals - pharmacokinetics
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Summary:As a general approach to radioligands with slow kinetics, studies in animals should be used to determine key pharmacological properties, like reversibility, of the radio-ligand; that long scans (and sometimes atypically long scans) be used to identify slow rate constants; and that retest studies can be unusually useful to identify sources of error in measurements of brain uptake and the concentration of radioligand in plasma, as well as in distribution volume, which is a ratio of brain to plasma measurements.
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ISSN:1619-7070
1619-7089
1619-7089
DOI:10.1007/s00259-010-1426-0