Quantitative Complexity Theory (QCT) in Integrative Analysis of Cardiovascular Hemodynamic Response to Posture Change

The explanation of physiological mechanisms involved in adaptation of the cardiovascular system to intrinsic and environmental demands is crucial for both basic science and clinical research. Computational algorithms integrating multivariable data that comprehensively depict complex mechanisms of ca...

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Published inLife (Basel, Switzerland) Vol. 13; no. 3; p. 632
Main Authors Krzesiński, Paweł, Marczyk, Jacek, Wolszczak, Bartosz, Gielerak, Grzegorz Gerard, Accardi, Francesco
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 24.02.2023
MDPI
Subjects
Algorithms
Analysis
Blood pressure
Cardiovascular diseases
Cardiovascular system
Case Report
complexity
Complexity theory
Computer applications
Diagnosis
Evaluation
Fainting
Heart rate
Hemodynamic monitoring
Hemodynamic responses
Hemodynamics
impedance cardiography
Medical research
Medicine, Experimental
Physiological aspects
Posture
Risk factors
Syncope
Italy
Germany
complexity
cardiovascular system
syncope
impedance cardiography
hemodynamics
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Summary:The explanation of physiological mechanisms involved in adaptation of the cardiovascular system to intrinsic and environmental demands is crucial for both basic science and clinical research. Computational algorithms integrating multivariable data that comprehensively depict complex mechanisms of cardiovascular reactivity are currently being intensively researched. Quantitative Complexity Theory (QCT) provides quantitative and holistic information on the state of multi-functional dynamic systems. The present paper aimed to describe the application of QCT in an integrative analysis of the cardiovascular hemodynamic response to posture change. Three subjects that underwent head-up tilt testing under beat-by-beat hemodynamic monitoring (impedance cardiography) were discussed in relation to the complexity trends calculated using QCT software. Complexity has been shown to be a sensitive marker of a cardiovascular hemodynamic response to orthostatic stress and vasodilator administration, and its increase has preceded changes in standard cardiovascular parameters. Complexity profiling has provided a detailed assessment of individual hemodynamic patterns of syncope. Different stimuli and complexity settings produce results of different clinical usability.
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ISSN:2075-1729
2075-1729
DOI:10.3390/life13030632