Trans-Dominant Inhibitory Human Immunodeficiency Virus Type 1 Protease Monomers Prevent Protease Activation and Virion Maturation
Production of infectious human immunodeficiency virus (HIV) requires proper polyprotein processing by the dimeric viral protease. The trans-dominant inhibitory activity of a defective protease monomer with the active site Asp-25 changed to Asn was measured by transient transfection. A proviral plasm...
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Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 92; no. 22; pp. 10069 - 10073 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
National Academy of Sciences of the United States of America
24.10.1995
National Acad Sciences National Academy of Sciences |
Subjects | |
Online Access | Get full text |
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