Increasing host cellular receptor—angiotensin‐converting enzyme 2 expression by coronavirus may facilitate 2019‐nCoV (or SARS‐CoV‐2) infection

• Published in: Journal of medical virology Vol. 92; no. 11; pp. 2693 - 2701
• Main Authors: Zhuang, Meng‐Wei, Cheng, Yun, Zhang, Jing, Jiang, Xue‐Mei, Wang, Li, Deng, Jian, Wang, Pei‐Hui
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2020; John Wiley and Sons Inc
• Subjects: 2019‐nCoV; ACE2; Angiotensin; Angiotensin-converting enzyme 2; Angiotensin-Converting Enzyme 2 - genetics; Angiotensin-Converting Enzyme 2 - immunology; Conversion; Coronaviridae; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - virology; Cytokines; Disease transmission; Drug delivery; Enzymes; Epidemics; Gene Expression; Health risks; HEK293 Cells; Humans; IFN; Infections; Infectious diseases; Inflammation; Interferon; Interferons - pharmacology; ISG; Microarray Analysis; Protein Binding; Proteins; Public health; Receptors; Receptors, Virus - genetics; Receptors, Virus - immunology; Respiratory diseases; Ribonucleic acid; Risk analysis; Risk factors; RNA; SARS Virus - genetics; SARS Virus - pathogenicity; SARS-CoV-2 - genetics; SARS-CoV-2 - pathogenicity; SARS‐CoV‐2; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Up-Regulation; Viral diseases; Virology; Viruses; COVID-19; IFN; ACE2; SARS-CoV-2; 2019-nCoV; ISG
• ISSN: 0146-6615; 1096-9071; 1096-9071
• DOI: 10.1002/jmv.26139

The ongoing outbreak of a new coronavirus (2019‐nCoV, or severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]) has caused an epidemic of the acute respiratory syndrome known as coronavirus disease (COVID‐19) in humans. SARS‐CoV‐2 rapidly spread to multiple regions of China and multiple other...