Investigation of the GnRH antagonist degarelix isomerization in biological matrices

• Published in: Pharmacology research & perspectives Vol. 11; no. 4; pp. e01117 - n/a
• Main Authors: Ferrazzano, Lucia, Tolomelli, Alessandra, Guryanov, Ivan, Macis, Marco, Abel, Ulrich, Ricci, Antonio, Cabri, Walter
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.08.2023; John Wiley and Sons Inc; Wiley
• Subjects: Amino acids; Calibration; Cancer therapies; Chromatography; degarelix; dihydroorotate; Gonadotropin-Releasing Hormone; Hormone Antagonists; hydantoin; Isomerism; Liver; metabolism; Methods; Molecular weight; Oligopeptides; Original; peptide; Peptides; Pharmaceuticals; Pharmacology; Prostate cancer; Proteins; United States > US; dihydroorotate; degarelix; peptide; metabolism; hydantoin

One of the main objectives of peptide drug design is the improvement of peptide pharmacokinetics with maintaining biological activity, which can be achieved by the complex modifications of the primary structure of the peptides. However, these changes often lead to the formation of peculiar impuritie...