Studies of anticancer drug cytotoxicity based on long‐term HepG2 spheroid culture in a microfluidic system

• Published in: Electrophoresis Vol. 38; no. 8; pp. 1206 - 1216
• Main Authors: Zuchowska, Agnieszka, Kwapiszewska, Karina, Chudy, Michal, Dybko, Artur, Brzozka, Zbigniew
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.04.2017
• Subjects: Anticancer drugs; Anticancer properties; Antineoplastic Agents - pharmacology; Antineoplastic Agents - toxicity; Cancer; Cell Survival - drug effects; Culture; Cytotoxicity; Drug resistance; Drug Resistance, Neoplasm; Drugs; Fluorouracil - pharmacology; Fluorouracil - toxicity; Hep G2 Cells; Humans; Liver; Liver cancer; Liver Neoplasms - pathology; Metabolism; Microfluidic Analytical Techniques; Microfluidics; Microfluidics - methods; Spheroid; Spheroids; Spheroids, Cellular - drug effects; Spheroids, Cellular - pathology; System effectiveness; Three dimensional models; Three‐dimensional cell culture; Toxicity; Tumor model; Viability; Anticancer drugs; Three-dimensional cell culture; Spheroid; Microfluidics; Tumor model

Cell‐on‐a‐chip systems have become promising devices to study the effectiveness of new anticancer drugs recently. Several microdevices for liver cancer culture and evaluation of the drug cytotoxicity have been reported. However, there are still no proven reports about high‐throughput and simple meth...