Cellular Location of HNF4α is Linked With Terminal Liver Failure in Humans

• Published in: Hepatology communications Vol. 4; no. 6; pp. 859 - 875
• Main Authors: Florentino, Rodrigo M., Fraunhoffer, Nicolas A., Morita, Kazutoyo, Takeishi, Kazuki, Ostrowska, Alina, Achreja, Abhinav, Animasahun, Olamide, Haep, Nils, Arazov, Shohrat, Agarwal, Nandini, Collin de l'Hortet, Alexandra, Guzman‐Lepe, Jorge, Tafaleng, Edgar N., Mukherjee, Amitava, Troy, Kris, Banerjee, Swati, Paranjpe, Shirish, Michalopoulos, George K., Bell, Aaron, Nagrath, Deepak, Hainer, Sarah J., Fox, Ira J., Soto‐Gutierrez, Alejandro
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins 01.06.2020; John Wiley and Sons Inc; Wolters Kluwer Health/LWW
• Subjects: Adenosine; Alcohol; Chromatography; Kinases; Laboratories; Liver cirrhosis; Liver diseases; Localization; Mass spectrometry; Metabolites; Original; Principal components analysis; Proteins; Scientific imaging; Transplants & implants

Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor that plays a critical role in hepatocyte function, and HNF4α‐based reprogramming corrects terminal liver failure in rats with chronic liver disease. In the livers of patients with advanced cirrhosis, HNF4α RNA expression levels decr...