The translocator protein gene is associated with endogenous pain modulation and the balance between glutamate and γ-aminobutyric acid in fibromyalgia and healthy subjects: a multimodal neuroimaging study

• Published in: Pain (Amsterdam) Vol. 163; no. 2; pp. 274 - 286
• Main Authors: Fanton, Silvia, Sandström, Angelica, Tour, Jeanette, Kadetoff, Diana, Schalling, Martin, Jensen, Karin B., Sitnikov, Rouslan, Ellerbrock, Isabel, Kosek, Eva
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer 01.02.2022
• Subjects: Brain; Endogenous pain modulation; Fibromyalgia; fMRI; GABA; gamma-Aminobutyric Acid - metabolism; Genetic polymorphism; Glutamate; Glutamic Acid - genetics; Glutamic Acid - metabolism; Healthy Volunteers; Humans; MRS; Neuroimaging; Pain - diagnostic imaging; Pain - genetics; Pain - metabolism; Positron-Emission Tomography - methods; rACC; Receptors, GABA - genetics; Receptors, GABA - metabolism; Research Paper; Thalamus; TSPO

A cerebral upregulation of the translocator protein (TSPO), a biomarker of glial activation, has been reported in fibromyalgia subjects (FMS). The TSPO binding affinity is genetically regulated by the Ala147Thr polymorphism in the TSPO gene ( rs6971 ) and allows for a subject classification into hig...